Strategy for a Biomimetic Paradigm in Dental and Craniofacial Tissue Engineering

Marei, Mona K.; Nagy, Naglaa B.; Saad, Marwa A.; Zaky, Samer H.; Backly, Rania M. El; Eweida, Ahmad; Alkhodary, Mohamed Ahmed

doi:10.1002/9781118810408.ch6

Cited by 4 publications

(1 citation statement)

References 188 publications

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“…4,5 This is mostly due to the large size of defect that results from tumor excision with adequate safety margins and due to the defective vascularity in the region after possible irradiation. 6,7 As regenerative medicine depends primarily on harnessing the body's regenerative capacity to replace the lost tissues, providing adequate vascularization of the construct (scaffold) that is used to bridge the defect is a determining issue. 8 The socalled "axially vascularized tissue engineering constructs" (AV-TECs) aim at providing adequate blood supply especially to the central regions of large defects independent of the vascularity of the local tissues, and thus represent a promising option for reconstruction of larger defects in poorly vascularized areas as it is the case after irradiation.…”

mentioning

confidence: 99%

Pattern of Bone Generation after Irradiation in Vascularized Tissue Engineered Constructs

Eweida

Fathi

Eltawila

et al. 2017

J reconstr Microsurg

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mentioning

confidence: 99%

Pattern of Bone Generation after Irradiation in Vascularized Tissue Engineered Constructs

Eweida

Fathi

Eltawila

et al. 2017

J reconstr Microsurg

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Axially vascularized tissue‐engineered bone constructs retain their in vivo angiogenic and osteogenic capacity after high‐dose irradiation

Eweida

Frisch

Giordano

et al. 2017

J Tissue Eng Regen Med

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In order to introduce bone tissue engineering to the field of oncological reconstruction, we are investigating for the first time the effect of various doses of ionizing irradiation on axially vascularized bone constructs. Synthetic bone constructs were created and implanted in 32 Lewis rats. Each construct was axially vascularized through an arteriovenous loop made by direct anastomosis of the saphenous vessels. After 2 weeks, the animals received ionizing irradiation of 9 Gy, 12 Gy and 15 Gy, and were accordingly classified to groups I, II and III, respectively. Group IV was not irradiated and acted as a control. Tissue generation, vascularity, cellular proliferation and apoptosis were investigated either 2 or 5 weeks after irradiation through micro-computed tomography, histomorphometry and real-time polymerase chain reaction (PCR). At 2 weeks after irradiation, tissue generation and central vascularity were significantly lower and apoptosis was significantly higher in groups II and III than group IV, but without signs of necrosis. Cellular proliferation was significantly lower in groups I and II. After 5 weeks, the irradiated groups showed improvement in all parameters in relation to the control group, indicating a retained capacity for angiogenesis after irradiation. PCR results confirmed the expression of osteogenesis-related genes in all irradiated groups. Dense collagen was detected 5 weeks after irradiation, and one construct showed discrete islands of bone indicating a retained osteogenic capacity after irradiation. This demonstrates for the first time that axial vascularization was capable of supporting a synthetic bone construct after a high dose of irradiation that is comparable to adjuvant radiotherapy. Copyright © 2016 John Wiley & Sons, Ltd.

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Swellings of the Jaw

Eweida

Horch

2016

Head and Neck and Endocrine Surgery

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Strategy for a Biomimetic Paradigm in Dental and Craniofacial Tissue Engineering

Cited by 4 publications

References 188 publications

Pattern of Bone Generation after Irradiation in Vascularized Tissue Engineered Constructs

Pattern of Bone Generation after Irradiation in Vascularized Tissue Engineered Constructs

Axially vascularized tissue‐engineered bone constructs retain their in vivo angiogenic and osteogenic capacity after high‐dose irradiation

Swellings of the Jaw

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