Strategy‐based reasoning training modulates cortical thickness and resting‐state functional connectivity in adults with chronic traumatic brain injury

Han, Kihwan; Davis, Rebecca; Chapman, Sandra B.; Krawczyk, Daniél C.

doi:10.1002/brb3.687

Cited by 35 publications

(36 citation statements)

References 135 publications

(173 reference statements)

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“…This property, known as neuroplasticity, has been demonstrated extensively in many brain regions by functional and structural magnetic resonance imaging (MRI) in the past two decades. In terms of brain lesions, including those resulting from brain injuries, strokes, and brain tumors, functional imaging studies have identified the brain to maintain its original features or to support functional recovery by recruiting other parts of the brain, such as the perilesional brain, contralesional brain, and homologous function of the brain, in order to compensate for lost functions (Small et al, 2002;Freundlieb et al, 2015;Fisicaro et al, 2016;Han et al, 2017Han et al, , 2018.…”

Section: Introductionmentioning

confidence: 99%

Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients

et al. 2020

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Background: The human brain has an extraordinary ability to functionally change or reorganize its structure in response to disease. The aim of this study is to assess the structural and functional plasticity of contralesional medial temporal lobe (MTL) in patients with unilateral MTL glioma.Methods: Sixty-eight patients with unilateral MTL glioma (left MTL glioma, n = 33; right MTL glioma, n = 35) and 40 healthy controls were recruited and scanned with 3D T1 MRI and rest-fMRI. We explored the structure of the contralesional MTL using voxelbased morphometry (VBM) and assessed the memory networks of the contralesional hemisphere using resting-state functional connectivity (rs-FC). The association between FC and cognitive function was assessed with partial correlation analysis.Results: Compared with healthy controls, both patient groups exhibited (1) a large cluster of voxels with gray matter (GM) volume decrease in the contralesional MTL using region of interest (ROI)-based VBM analysis (cluster level p < 0.05, FDR corrected); and (2) decreased intrahemispheric FC between the posterior hippocampus (pHPC) and posterior cingulate cortex (PCC) (p < 0.01, Bonferroni corrected). Intrahemispheric FC between the pHPC and PCC was positively correlated with cognitive function in both patient groups.Conclusion: Using multi-modality brain imaging tools, we found structural and functional changes in the contralesional MTL in patients with unilateral MTL glioma. These findings suggest that the contralesional cortex may have decompensation of structure and function in patients with unilateral glioma, except for compensatory structural and functional adaptations. Our study provides additional insight into the neuroanatomical and functional network changes in the contralesional cortex in patients with glioma.

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Section: Introductionmentioning

confidence: 99%

Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients

et al. 2020

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“…[13][14][15] Accordingly, the neurorehabilitation community seeks to identify training-induced neuroplasticity of the injured brain. 16,17 Previously, we reported the efficacy of cognitive training in TBI and its underlying neuroplasticity [18][19][20][21] as measured by changes in cortical thickness, cerebral blood flow, and resting-state functional connectivity.…”

Section: Introductionmentioning

confidence: 99%

Cognitive Training Reorganizes Network Modularity in Traumatic Brain Injury

Han

Chapman

Krawczyk

2019

Neurorehabil Neural Repair

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Background. Graph-theoretic approaches are increasingly popular for identifying the patterns of disrupted neural systems after traumatic brain injury (TBI). However, the patterns of neuroplasticity in brain organization after cognitive training in TBI are less well understood. Objective. We identified the patterns of training-induced neuroplasticity of the whole-brain network in TBI, using resting-state functional connectivity and graph theory. Methods. A total of 64 civilians and veterans with TBI were randomized into either a strategy-based cognitive training group (n = 33) or a knowledge-based training group (active control group; n = 31) for 8 weeks. The participants experienced mild to severe TBI without focal damage and persistent cognitive dysfunctions. A subset of participants complained of subclinical but residual psychiatric symptoms. We acquired their resting-state functional magnetic resonance imaging before training, immediately posttraining, and 3 months posttraining. From participants’ resting-state networks, we obtained the modularity, participation coefficient, within-module connectivity, global efficiency, and local efficiency over multiple network densities. We next performed longitudinal analyses on those measures corrected for multiple comparisons across network densities using false discovery rate (FDR). Results. Relative to the knowledge-based training group, the strategy-based cognitive training group had reduced modularity and increased participation coefficient, global efficiency, and local efficiency over time ( Pnodal < .05; qFDR < 0.05). Brain behavior analysis revealed that the participation coefficient and global efficiency within the strategy-based cognitive training group correlated with trail-making scores in the context of training ( Pnodal < .05; qFDR < 0.05). Conclusions. Cognitive training reorganized modular networks in TBI over the whole brain. Graph-theoretic approaches may be useful in identifying a potential brain-based marker of training efficacy in TBI.

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“…Our previous study demonstrated that brain regions where training‐induced cortical thickness changes occurred also impacted corresponding resting‐state functional connectivity (Han et al, ). Thus, we selected four seed regions where statistically significant associations between temporal changes in cortical thickness and total BDI scores occurred, and we assessed their seed‐based connectivity.…”

Section: Methodsmentioning

confidence: 98%

“…Initial injury severity was retrospectively estimated utilizing the Ohio State University TBI identification method (OSU TBI‐ID; Corrigan & Bogner, ). The rationale for utilizing the OSU TBI‐ID is described in detail in our previous study (Han et al, ). Both civilians and military veterans were included (See Table for demographics).…”

Section: Methodsmentioning

confidence: 99%

“…Previously, we reported the efficacy of a strategy‐based reasoning intervention for chronic TBI, compared to an information‐based intervention (Vas et al, ), and the underlying neuroplasticity following intervention (Han, Davis, Chapman, & Krawczyk, ). Both intervention programs in our previous study included social interactions in small group settings with regular meetings comprised of multiple individuals with TBI and social contact with instructors who fostered an empathetic environment for the participants along with cognitive activities.…”

Section: Introductionmentioning

confidence: 99%

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Neural correlates of reduced depressive symptoms following cognitive training for chronic traumatic brain injury

Han

Martínez

Chapman

et al. 2018

Human Brain Mapping

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Depression is the most frequent comorbid psychiatric condition among individuals with traumatic brain injury (TBI). Yet, little is known about changes in the brain associated with reduced depressive symptoms following rehabilitation for TBI. We identified whether cognitive training alleviates comorbid depressive symptoms in chronic TBI (>6 months post‐injury) as a secondary effect. Further, we elucidated neural correlates of alleviated depressive symptoms following cognitive training. A total of seventy‐nine individuals with chronic TBI (53 depressed and 26 non‐depressed individuals, measured using the Beck Depressive Inventory [BDI]), underwent either strategy‐ or information‐based cognitive training in a small group for 8 weeks. We measured psychological functioning scores, cortical thickness, and resting‐state functional connectivity (rsFC) for these individuals before training, immediately post‐training, and 3 months post‐training. After confirming that changes in BDI scores were independent of training group affiliation, we identified that the depressive‐symptoms group showed reductions in BDI scores over time relative to the non‐depressed TBI controls (p < .01). Within the depressive‐symptoms group, reduced BDI scores was associated with improvements in scores for post‐traumatic stress disorder, TBI symptom awareness, and functional status (p < .00625), increases in cortical thickness in four regions within the right prefrontal cortex (p vertex < .01, p cluster<.05), and decreases in rsFC with each of these four prefrontal regions (p vertex < .01, p cluster < .0125). Overall, these findings suggest that cognitive training can reduce depressive symptoms in TBI even when the training does not directly target psychiatric symptoms. Importantly, cortical thickness and brain connectivity may offer promising neuroimaging markers of training‐induced improvement in mental health status in TBI.

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Strategy‐based reasoning training modulates cortical thickness and resting‐state functional connectivity in adults with chronic traumatic brain injury

Cited by 35 publications

References 135 publications

Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients

Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients

Cognitive Training Reorganizes Network Modularity in Traumatic Brain Injury

Neural correlates of reduced depressive symptoms following cognitive training for chronic traumatic brain injury

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