Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients

Yuan, Taoyang; Zuo, Zhentao; Ying, Jianyou; Kang, Jie; Gui, Songbai; Wang, Rui; Li, Chuzhong

doi:10.3389/fnins.2020.00010

Cited by 23 publications

(32 citation statements)

References 44 publications

(48 reference statements)

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“…Aging can affect GMV; hence, studies comparing patients and healthy participants typically consider age as an uninteresting variable (3,7,22). It should be noted that HGG, IDH-wt, and TERTp-mu in glioma were found to be closely related to older age (16,23), which was also the case in our study (Table 1).…”

Section: Participants and Groupingsupporting

confidence: 82%

“…Additionally, reactive functional and structural plasticity is responsible for restoring normal brain function following injury, a process known as cortical remodeling or reorganization (2). Neuroimaging studies have revealed that this process occurs in both the lesioned and intact hemispheres in stroke, brain trauma, and glioma (3)(4)(5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

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Contralesional Structural Plasticity in Different Molecular Pathologic Subtypes of Insular Glioma

Huang

et al. 2021

Front. Neurol.

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Neuroplasticity may preserve neurologic function in insular glioma, thereby improving prognosis following resection. However, the anatomic and molecular bases of this phenomenon are not known. To address this gap in knowledge, the present study investigated contralesional compensation in different molecular pathologic subtypes of insular glioma by high-resolution three-dimensional T1-weighted structural magnetic resonance imaging. A total of 52 patients with insular glioma were examined. We compared the gray matter volume (GMV) of the contralesional insula according to histological grade [low-grade glioma (LGG) and high-grade glioma (HGG)] and molecular pathology status [isocitrate dehydrogenase (IDH) mutation, telomerase reverse-transcriptase (TERT) promoter mutation, and 1p19q codeletion] by voxel-based morphometry (VBM). A cluster of 320 voxels in contralesional insula with higher GMV was observed in glioma with IDH mutation as compared to IDH wild-type tumors by region of interest-based VBM analysis (family-wise error-corrected at p < 0.05). The GMV of the entire contralesional insula was also larger in insular glioma patients with IDH mutation than in patients with wild-type IDH. However, there was no association between histological grade, TERT promoter mutation, or 1p19q codeletion and GMV in the contralesional insula. Thus, IDH mutation is associated with greater structural compensation in insular glioma. These findings may be useful for predicting neurocognitive and functional outcomes in patients undergoing resection surgery.

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Section: Participants and Groupingsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Contralesional Structural Plasticity in Different Molecular Pathologic Subtypes of Insular Glioma

Huang

et al. 2021

Front. Neurol.

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“…It poses a huge toll on healthcare resources and productivity 52 . Despite extensive research, still has limited treatment options available 9 , 12 . To our knowledge, this is the first prospective, negative controlled, double-blinded study to compare the effect of commonly used and novel IA treatments for the management of OA, in a naturally occurring canine model, with a long follow up period.…”

Section: Discussionmentioning

confidence: 99%

“…The medical approach to OA aims at slowing disease progression while relieving symptoms, particularly pain, and improving overall function 9 , 12 . Imaging plays a key role in the assessment of patients with joint disease.…”

Section: Introductionmentioning

confidence: 99%

Intraarticular triamcinolone hexacetonide, stanozolol, Hylan G-F 20 and platelet concentrate in a naturally occurring canine osteoarthritis model

Alves

Santos²,

Jorge³

et al. 2021

Sci Rep

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Osteoarthritis (OA) is a disease transversal to all mammals, a source of chronic pain and disability, a huge burden to societies, with a significant toll in healthcare cost, while reducing productivity and quality of life. The dog is considered a useful model for the translational study of the disease, closely matching human OA, with the advantage of a faster disease progression while maintaining the same life stages. In a prospective, longitudinal, double-blinded, negative controlled study, one hundred (N = 100) hip joints were selected and randomly assigned to five groups: control group (CG, n = 20, receiving a saline injection), triamcinolone hexacetonide group (THG, n = 20), platelet concentrate group (PCG, n = 20), stanozolol group (SG, n = 20) and hylan G-F 20 group (HG). Evaluations were conducted on days 0 (T0, treatment day), 8, 15, 30, 60, 90, 120, 150 and 180 days post-treatment, consisting of weight distribution analysis and data from four Clinical Metrology Instruments (CMI). Kaplan–Meier estimators were generated and compared with the Breslow test. Cox proportional hazard regression analysis was used to investigate the influence of variables of interest on treatment survival. All results were analyzed with IBM SPSS Statistics version 20 and a significance level of p < 0.05 was set. Sample included joints of 100 pelvic limbs (of patients with a mean age of 6.5 ± 2.4 years and body weight of 26.7 ± 5.2 kg. Joints were graded as mild (n = 70), moderate (n = 20) and severe (n = 10) OA. No differences were found between groups at T0. Kaplan–Meier analysis showed that all treatments produced longer periods with better results in the various evaluations compared to CG. Patients in HG and PCG took longer to return to baseline values and scores. A higher impact on pain interference was observed in THG, with a 95% improvement over CG. PCG and HG experienced 57–81% improvements in functional evaluation and impairments due to OA, and may be a better options for these cases. This study documented the efficacy of several approaches to relieve OA clinical signs. These approaches varied in intensity and duration. HG and PCG where the groups were more significant improvements were observed throughout the follow-up periods, with lower variation in results.

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“…Connectivity-based analysis is an approach of choice for exploring the functional remodeling of cerebral gliomas at both local and global levels. Brain networks of default mode, language and hand-motor showed profoundly reduced functional integrity ( Briganti et al, 2012 ; Mallela et al, 2016 ; Kocher et al, 2020 ), and altered inter- and intra- network connectivity in the contralesional hemisphere in subjects with advanced gliomas ( De Baene et al, 2017 ; Fox and King, 2018 ; Yuan et al, 2020 ). These connectivity-based findings indicate that the growth of glioma triggers both intra- and inter-hemispheric functional remodeling.…”

Section: Introductionmentioning

confidence: 99%

Hemisphere-Specific Functional Remodeling and Its Relevance to Tumor Malignancy of Cerebral Glioma Based on Resting-State Functional Network Analysis

et al. 2021

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Background: Functional remodeling may vary with tumor aggressiveness of glioma. Investigation of the functional remodeling is expected to provide scientific relevance of tumor characterization and disease management of glioma. In this study, we aimed to investigate the functional remodeling of the contralesional hemisphere and its utility in predicting the malignant grade of glioma at the individual level with multivariate logistic regression (MLR) analysis. Subjects and Methods: One hundred and twenty-six right-handed subjects with histologically confirmed cerebral glioma were included with 80 tumors located in the left hemisphere (LH) and 46 tumors located in the right hemisphere (RH). Resting-state functional networks of the contralesional hemisphere were constructed using the human brainnetome atlas based on resting-state fMRI data. Functional connectivity and topological features of functional networks were quantified. The performance of functional features in predicting the glioma grade was evaluated using area under (AUC) the receiver operating characteristic curve (ROC). The dataset was divided into training and validation datasets. Features with high AUC values in malignancy classification in the training dataset were determined as predictive features. An MLR model was constructed based on predictive features and its classification performance was evaluated on the training and validation datasets with 10-fold cross validation. Results: Predictive functional features showed apparent hemispheric specifications. MLR classification models constructed with age and predictive functional connectivity features (AUC of 0.853 ± 0.079 and 1.000 ± 0.000 for LH and RH group, respectively) and topological features (AUC of 0.788 ± 0.150 and 0.897 ± 0.165 for LH and RH group, respectively) achieved efficient performance in predicting the malignant grade of gliomas. Conclusion: Functional remodeling of the contralesional hemisphere was hemisphere-specific and highly predictive of the malignant grade of glioma. Network approach provides a novel pathway that may innovate glioma characterization and management at the individual level.

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Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients

Cited by 23 publications

References 44 publications

Contralesional Structural Plasticity in Different Molecular Pathologic Subtypes of Insular Glioma

Contralesional Structural Plasticity in Different Molecular Pathologic Subtypes of Insular Glioma

Intraarticular triamcinolone hexacetonide, stanozolol, Hylan G-F 20 and platelet concentrate in a naturally occurring canine osteoarthritis model

Hemisphere-Specific Functional Remodeling and Its Relevance to Tumor Malignancy of Cerebral Glioma Based on Resting-State Functional Network Analysis

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