2020
DOI: 10.3389/fnins.2020.00010
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Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients

Abstract: Background: The human brain has an extraordinary ability to functionally change or reorganize its structure in response to disease. The aim of this study is to assess the structural and functional plasticity of contralesional medial temporal lobe (MTL) in patients with unilateral MTL glioma.Methods: Sixty-eight patients with unilateral MTL glioma (left MTL glioma, n = 33; right MTL glioma, n = 35) and 40 healthy controls were recruited and scanned with 3D T1 MRI and rest-fMRI. We explored the structure of the … Show more

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Cited by 23 publications
(32 citation statements)
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“…Aging can affect GMV; hence, studies comparing patients and healthy participants typically consider age as an uninteresting variable (3,7,22). It should be noted that HGG, IDH-wt, and TERTp-mu in glioma were found to be closely related to older age (16,23), which was also the case in our study (Table 1).…”
Section: Participants and Groupingsupporting
confidence: 82%
See 1 more Smart Citation
“…Aging can affect GMV; hence, studies comparing patients and healthy participants typically consider age as an uninteresting variable (3,7,22). It should be noted that HGG, IDH-wt, and TERTp-mu in glioma were found to be closely related to older age (16,23), which was also the case in our study (Table 1).…”
Section: Participants and Groupingsupporting
confidence: 82%
“…Additionally, reactive functional and structural plasticity is responsible for restoring normal brain function following injury, a process known as cortical remodeling or reorganization (2). Neuroimaging studies have revealed that this process occurs in both the lesioned and intact hemispheres in stroke, brain trauma, and glioma (3)(4)(5)(6)(7)(8)(9)(10).…”
Section: Introductionmentioning
confidence: 99%
“…It poses a huge toll on healthcare resources and productivity 52 . Despite extensive research, still has limited treatment options available 9 , 12 . To our knowledge, this is the first prospective, negative controlled, double-blinded study to compare the effect of commonly used and novel IA treatments for the management of OA, in a naturally occurring canine model, with a long follow up period.…”
Section: Discussionmentioning
confidence: 99%
“…The medical approach to OA aims at slowing disease progression while relieving symptoms, particularly pain, and improving overall function 9 , 12 . Imaging plays a key role in the assessment of patients with joint disease.…”
Section: Introductionmentioning
confidence: 99%
“…Connectivity-based analysis is an approach of choice for exploring the functional remodeling of cerebral gliomas at both local and global levels. Brain networks of default mode, language and hand-motor showed profoundly reduced functional integrity ( Briganti et al, 2012 ; Mallela et al, 2016 ; Kocher et al, 2020 ), and altered inter- and intra- network connectivity in the contralesional hemisphere in subjects with advanced gliomas ( De Baene et al, 2017 ; Fox and King, 2018 ; Yuan et al, 2020 ). These connectivity-based findings indicate that the growth of glioma triggers both intra- and inter-hemispheric functional remodeling.…”
Section: Introductionmentioning
confidence: 99%