Strategies towards injectable, load-bearing materials for the intervertebral disc: a review and outlook

Persson, Cecilia; Berg, S. Van Den

doi:10.1007/s10856-012-4776-2

Cited by 5 publications

(4 citation statements)

References 59 publications

(84 reference statements)

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“…Several systematic studies have been conducted to evaluate the radiopacity of injectable CPCs. These studies have emphasized the importance of investigating the radiopacity of injectable bone cement [ 254 , 255 , 256 , 257 ]. In addition to radiopacity, other properties such as mechanical properties, degradation profile, and porosity are important parameters to study in CPC composites [ 258 ].…”

Section: General Principles Of Bone Substitute Synthesismentioning

confidence: 99%

Synthetic Calcium–Phosphate Materials for Bone Grafting

Mishchenko,

Yanovska,

Kosinov

et al. 2023

Polymers

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Synthetic bone grafting materials play a significant role in various medical applications involving bone regeneration and repair. Their ability to mimic the properties of natural bone and promote the healing process has contributed to their growing relevance. While calcium–phosphates and their composites with various polymers and biopolymers are widely used in clinical and experimental research, the diverse range of available polymer-based materials poses challenges in selecting the most suitable grafts for successful bone repair. This review aims to address the fundamental issues of bone biology and regeneration while providing a clear perspective on the principles guiding the development of synthetic materials. In this study, we delve into the basic principles underlying the creation of synthetic bone composites and explore the mechanisms of formation for biologically important complexes and structures associated with the various constituent parts of these materials. Additionally, we offer comprehensive information on the application of biologically active substances to enhance the properties and bioactivity of synthetic bone grafting materials. By presenting these insights, our review enables a deeper understanding of the regeneration processes facilitated by the application of synthetic bone composites.

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Section: General Principles Of Bone Substitute Synthesismentioning

confidence: 99%

Synthetic Calcium–Phosphate Materials for Bone Grafting

Mishchenko,

Yanovska,

Kosinov

et al. 2023

Polymers

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“…A frequency of 5 Hz was used and the maximum stress level was set to 13 MPa, based on preliminary testing, and similar to what has previously been used for a calcium sulphate and phosphate-based bone cement [ 9 ]. This stress level is also in the range of reported compressive strengths of human trabecular bone (1–23 MPa) [ 37 – 39 ], and higher than what has been suggested for fatigue testing of materials for spinal applications (5 MPa) [ 40 ]— one suggested use for ceramic cements in load-bearing applications is vertebroplasty [ 14 , 41 ]. The specimens were tested until catastrophic failure, i.e., until occurrence of a sudden drop in stress, or a run-out of 5 million cycles, as indicated by the standard for fatigue testing of acrylic bone cements [ 23 ].…”

Section: Methodsmentioning

confidence: 98%

Compressive fatigue properties of an acidic calcium phosphate cement—effect of phase composition

Ajaxon

Öhman‐Mägi

Persson

2017

J Mater Sci: Mater Med

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Calcium phosphate cements (CPCs) are synthetic bone grafting materials that can be used in fracture stabilization and to fill bone voids after, e.g., bone tumour excision. Currently there are several calcium phosphate-based formulations available, but their use is partly limited by a lack of knowledge of their mechanical properties, in particular their resistance to mechanical loading over longer periods of time. Furthermore, depending on, e.g., setting conditions, the end product of acidic CPCs may be mainly brushite or monetite, which have been found to behave differently under quasi-static loading. The objectives of this study were to evaluate the compressive fatigue properties of acidic CPCs, as well as the effect of phase composition on these properties. Hence, brushite cements stored for different lengths of time and with different amounts of monetite were investigated under quasi-static and dynamic compression. Both storage and brushite-to-monetite phase transformation was found to have a pronounced effect both on quasi-static compressive strength and fatigue performance of the cements, whereby a substantial phase transformation gave rise to a lower mechanical resistance. The brushite cements investigated in this study had the potential to survive 5 million cycles at a maximum compressive stress of 13 MPa. Given the limited amount of published data on fatigue properties of CPCs, this study provides an important insight into the compressive fatigue behaviour of such materials.

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“…Inorganic radiopaque agents such as barium sulfate, strontium carbonate, bismuth salicylate basic and zirconium dioxide are usually incorporated into CaP cements, yet this incorporation could cause changes in the physiochemical properties [ 45 , [79] , [80] , [81] ]. Overall, several systematic researches on radiopacity evaluation of injectable CPCs have been undertaken [ [82] , [83] , [84] , [85] ]. These studies highlighted the need for examining the radiopacity of an injectable bone cement.…”

Section: Properties Of Injectable Cap Bone Cementsmentioning

confidence: 99%

“…These studies highlighted the need for examining the radiopacity of an injectable bone cement. Overall it was concluded that the evaluation parameters for radiopacity should be similar with those of the clinical procedures which are 60–130 kV and 3.1–10 mAs [ 83 ].…”

Section: Properties Of Injectable Cap Bone Cementsmentioning

confidence: 99%