Strategies to expand the therapeutic potential of superoxide dismutase by exploiting delivery approaches

Rosa, Arianna Carolina; Bruni, Natascia; Meineri, Giorgia; Corsi, Daniele; Cavi, Niccolò; Gastaldi, Daniela; Dosio, Franco

doi:10.1016/j.ijbiomac.2020.11.149

Cited by 29 publications

(11 citation statements)

References 156 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the use of SOD mimetics and new delivery systems to protect SOD are under investigation [23]. SOD mimetics are intended to overcome the limits of natural SOD enzymes.…”

Section: Introductionmentioning

confidence: 99%

Superoxide Dismutase Administration: A Review of Proposed Human Uses

et al. 2021

Self Cite

View full text Add to dashboard Cite

Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant defense against oxidative stress in the body. SOD supplementation may therefore trigger the endogenous antioxidant machinery for the neutralization of free-radical excess and be used in a variety of pathological settings. This paper aimed to provide an extensive review of the possible uses of SODs in a range of pathological settings, as well as describe the current pitfalls and the delivery strategies that are in development to solve bioavailability issues. We carried out a PubMed query, using the keywords “SOD”, “SOD mimetics”, “SOD supplementation”, which included papers published in the English language, between 2012 and 2020, on the potential therapeutic applications of SODs, including detoxification strategies. As highlighted in this paper, it can be argued that the generic antioxidant effects of SODs are beneficial under all tested conditions, from ocular and cardiovascular diseases to neurodegenerative disorders and metabolic diseases, including diabetes and its complications and obesity. However, it must be underlined that clinical evidence for its efficacy is limited and consequently, this efficacy is currently far from being demonstrated.

show abstract

“…Thus, the use of SOD mimetics and new delivery systems to protect SOD are under investigation [23]. SOD mimetics are intended to overcome the limits of natural SOD enzymes.…”

Section: Introductionmentioning

confidence: 99%

Superoxide Dismutase Administration: A Review of Proposed Human Uses

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, there were differences in the extent of enzyme activity increase in the various microalgae. Not only is SOD a superoxide anion scavenger enzyme, but it is also a major hydrogen peroxide-producing enzyme with an important role in biological antioxidant systems [38]. Some microalgae had reduced enzyme activity when the NA dose was relatively low, and some species still exhibited ideal SOD after prolonged exposure.…”

Section: Discussionmentioning

confidence: 99%

Toxicity of Naphthenic Acids on the Chlorophyll Fluorescence Parameters and Antioxidant Enzyme Activity of Heterosigma akashiwo

et al. 2021

View full text Add to dashboard Cite

Petroleum hydrocarbons can serve as a carbon source for marine phytoplankton; so, marine high-acid crude oil pollution events are likely to result in algal outbreaks or harmful algal blooms (HABs) in surface waters. Naphthenic acids (NAs) are the primary acidic component of crude oil, and red tide is of great concern due to its high diffusivity and strong destructive properties. It is important to study the mechanism of the toxic effect of NAs on the typical red tide algae, Heterosigma akashiwo, for the balance and stability of marine algae. The mechanism of NAs’ damage effect was investigated in terms of the antioxidant enzyme activity, cell number, the chlorophyll positive fluorescence parameters, and the cell morphology of microalgae. Experiments confirmed the hormesis of low-concentration (0.5, 2, and 4 mg/L) NAs on Heterosigma akashiwo, and the indicators of high-concentration (8 and 16 mg/L) NA exposures showed inhibition. In this study, the toxic effect of NAs on the target organism showed a clear concentration–dose relationship. The 16 mg/L NAs stress caused severe damage to the morphology and structure of the target biological cells in a short time (96 h), and the population growth decreased. The target organisms showed a staged oxidative stress response to NAs. The behavior in the low-concentration treatment groups showed toxicant excitatory effects on the photosynthetic efficiency and antioxidant enzyme activity of the target organisms. This study provides theoretical and practical data for the development of an important toxicological model of the toxicant’s excitement effects and antioxidant defense mechanisms. In addition, it provides prospective research data for the prediction and avoidance of ecological risk from NA pollution in marine environments.

show abstract

“…Although their high molecular weight limits the skin penetration of enzymes, they have been recommended for skincare products including enzymatic antioxidants, DNA-repairing enzymes, hyaluronidases, lipases, and exfoliating enzymes [ 165 ]. Moreover, the use of enzymes in cosmetic products is expected to be enhanced by their nanoformulation [ 166 ]. For instance, the liposomal formulation of photolyase, referred to as photosomes, revealed the ability of the enzyme to repair UVB induced cyclobutane pyrimidine dimers in human keratinocytes [ 167 ].…”

Section: Active Ingredients In Cosmetic Nanocarriersmentioning

confidence: 99%

Nanocarriers as Active Ingredients Enhancers in the Cosmetic Industry—The European and North America Regulation Challenges

Oliveira

Coelho²,

Teixeira

et al. 2022

Molecules

View full text Add to dashboard Cite

“Flawless skin is the most universally desired human feature” is an iconic statement by Desmond Morris. Skin indicates one´s health and is so important that it affects a person’s emotional and psychological behavior, these facts having propelled the development of the cosmetics industry. It is estimated that in 2023, this industry will achieve more than 800 billion dollars. This boost is due to the development of new cosmetic formulations based on nanotechnology. Nanocarriers have been able to solve problems related to active ingredients regarding their solubility, poor stability, and release. Even though nanocarriers have evident benefits, they also present some problems related to the high cost, low shelf life, and toxicity. Regulation and legislation are two controversial topics regarding the use of nanotechnology in the field of cosmetics. In this area, the U.S. FDA has taken the lead and recommended several biosafety studies and post-market safety evaluations. The lack of a global definition that identifies nanomaterials as a cosmetic ingredient is a hindrance to the development of global legislation. In the EU, the legislation regarding the biosafety of nanomaterials in cosmetics is stricter. “The cost is not the only important issue, safety and the application of alternative testing methods for toxicity are of crucial importance as well”.

show abstract

Strategies to expand the therapeutic potential of superoxide dismutase by exploiting delivery approaches

Cited by 29 publications

References 156 publications

Superoxide Dismutase Administration: A Review of Proposed Human Uses

Superoxide Dismutase Administration: A Review of Proposed Human Uses

Toxicity of Naphthenic Acids on the Chlorophyll Fluorescence Parameters and Antioxidant Enzyme Activity of Heterosigma akashiwo

Nanocarriers as Active Ingredients Enhancers in the Cosmetic Industry—The European and North America Regulation Challenges

Contact Info

Product

Resources

About