Strategies on biosynthesis and production of bioactive compounds in medicinal plants

Guo, Miaoxian; Lv, Haizhou; Chen, Hongyu; Dong, Shuting; Zhang, Jianhong; Liu, Wanjing; He, Liu; Ma, Yimian; Yu, Hua; Chen, Shilin; Luo, Hongmei

doi:10.1016/j.chmed.2023.01.007

Cited by 5 publications

(5 citation statements)

References 140 publications

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“…This variability underscores the importance of considering plant species when assessing heavy metal contamination. The impact of heavy metal contamination on the biosynthesis of secondary metabolites in medicinal plants is another area that needs more research [ 3 , 87 ]. Changes in the quantity and quality of these compounds could potentially affect the medicinal properties of these plants.…”

Section: Heavy Metal Pollution Of the Environment And Concerns For Me...mentioning

confidence: 99%

“…This disruption may particularly affect the synthesis of compounds like antioxidants and antimicrobial agents. Secondly, heavy metal stress can impact the activity of enzymes involved in the biosynthesis of bioactive compounds, contributing to observed alterations in the concentrations of secondary metabolites [ 3 , 13 , 120 ].…”

Section: Heavy Metal Pollution Of the Environment And Concerns For Me...mentioning

confidence: 99%

“…This interaction between pathways not only signifies a disturbance in the complex network of biochemical processes but also raises implications for the overall chemical profile of medicinal plants. So, it is important to explore the compromised biosynthetic equipment, revealing altered concentrations of secondary metabolites due to heavy metal exposure, as follows [ 3 , 67 ]:…”

Section: Mechanisms Of Heavy Metal-induced Changes In Antioxidant Act...mentioning

confidence: 99%

“…Alkaloids, flavonoids, terpenoids, and polyphenols stand as chemicals of therapeutic effects. Their profound significance lies not only in the richness of diversity they bring, but also in the versatile roles they play—from antioxidant defenders shielding cells against oxidative stress to anti-inflammatory agents soothing the body’s unrestrained responses [ 2 , 3 , 4 ] In addition to their antioxidant properties, many medicinal plants also possess anticarcinogenic properties, meaning they can inhibit the growth and spread of cancer cells [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Asiminicesei,

Fertu,

Gavrilescu

2024

Plants

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The paper provides a comprehensive examination of heavy metal stress on medicinal plants, focusing on its impact on antioxidant capacity and biosynthetic pathways critical to their therapeutic potential. It explores the complex relationship between heavy metals and the physiological and biochemical responses of medicinal plants, highlighting how metal stress disrupts biosynthetic pathways, altering concentrations of secondary metabolites. This disruption may compromise the overall quality and efficacy of medicinal plants, requiring a holistic understanding of its cumulative impacts. Furthermore, the study discusses the potential of targeted genetic editing to enhance plant resilience against heavy metal stress by manipulating genes associated with antioxidant defenses. This approach represents a promising frontier in safeguarding medicinal plants in metal-contaminated environments. Additionally, the research investigates the role of phytohormone signaling in plant adaptive mechanisms to heavy metal stress, revealing its influence on biochemical and physiological responses, thereby adding complexity to plant adaptation. The study underscores the importance of innovative technologies and global cooperation in protecting medicinal plants’ therapeutic potential and highlights the need for mitigation strategies to address heavy metal contamination effectively.

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Section: Heavy Metal Pollution Of the Environment And Concerns For Me...mentioning

confidence: 99%

Section: Heavy Metal Pollution Of the Environment And Concerns For Me...mentioning

confidence: 99%

Section: Mechanisms Of Heavy Metal-induced Changes In Antioxidant Act...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Asiminicesei,

Fertu,

Gavrilescu

2024

Plants

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“…The integration of synthetic biology into the production of bioactive components from fruits has the potential to significant influence the status of FBPs utilization. By employing engineered microbial strains, researchers can design efficient and cost-effective pathways for the synthesis of specific bioactive compounds that are naturally present in FBPs (Guo et al 2023 ; Kowalczyk et al 2022 ). Research showed that several enzymes could be produced from fruit by-products by the application of microbial strains.…”

Section: Necessity Of Physical Pretreatment Before Utilization Of Fbpsmentioning

confidence: 99%

Trends and challenges of fruit by-products utilization: insights into safety, sensory, and benefits of the use for the development of innovative healthy food: a review

Hasan,

Islam,

Haque

et al. 2024

Bioresour. Bioprocess.

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A significant portion of the human diet is comprised of fruits, which are consumed globally either raw or after being processed. A huge amount of waste and by-products such as skins, seeds, cores, rags, rinds, pomace, etc. are being generated in our homes and agro-processing industries every day. According to previous statistics, nearly half of the fruits are lost or discarded during the entire processing chain. The concern arises when those wastes and by-products damage the environment and simultaneously cause economic losses. There is a lot of potential in these by-products for reuse in a variety of applications, including the isolation of valuable bioactive ingredients and their application in developing healthy and functional foods. The development of novel techniques for the transformation of these materials into marketable commodities may offer a workable solution to this waste issue while also promoting sustainable economic growth from the bio-economic viewpoint. This approach can manage waste as well as add value to enterprises. The goal of this study is twofold based on this scenario. The first is to present a brief overview of the most significant bioactive substances found in those by-products. The second is to review the current status of their valorization including the trends and techniques, safety assessments, sensory attributes, and challenges. Moreover, specific attention is drawn to the future perspective, and some solutions are discussed in this report.

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Fermentation-mediated sustainable development and improvement of quality of plant-based foods: from waste to a new food

Hashimoto,

de Cassia Campos Pena,

da Cunha

et al. 2024

Syst Microbiol and Biomanuf

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Strategies on biosynthesis and production of bioactive compounds in medicinal plants

Cited by 5 publications

References 140 publications

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Trends and challenges of fruit by-products utilization: insights into safety, sensory, and benefits of the use for the development of innovative healthy food: a review

Fermentation-mediated sustainable development and improvement of quality of plant-based foods: from waste to a new food

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