Strategies of airway management for head and neck photo‐dynamic therapy

Story, William T.; Sultan, Ahmed A.; Bottini, Gian Battista; Vaz, Francis; Lee, Gene; Hopper, Colin

doi:10.1002/lsm.22149

Cited by 30 publications

(17 citation statements)

References 12 publications

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“…Obviously, appearance of new photosensitizers being developed will not only extend the number of choices for treating cancers already treated with photofrin, but extend the indications as well. According to previous reports, an ideal for PDT should meet several criteria: (1) chemical stability, (2) water-solubility, (3) high quantum yield of 1 O 2 generation,(4) no cytotoxicity in the dark, (5) tumor selectivity, (6) rapid accumulation in target tumor tissues, (7) rapid clearance from patients, (8) a high molar absorption coefficient in the long wavelength (600-800 nm) that can penetrate deeper tissues, etc (25,52,53).…”

Section: Discussionmentioning

confidence: 99%

“…It is based on preferential uptake of photosensitizers in tumor cells or tissues, and subsequent activation with appropriate wavelength of laser light, resulting in tumor cells killing by activated oxygen produced by the photosensitizers . As a safe and minimally invasive therapy, it has been clinically applied to many kinds of cancers, such as lung , cervical , early esophageal , bladder , melanoma and head and neck cancers , etc.…”

Section: Introductionmentioning

confidence: 99%

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Antitumor Effect of Sinoporphyrin Sodium‐Mediated Photodynamic Therapy on Human Esophageal Cancer Eca‐109 Cells

Wang

Liu

et al. 2014

Photochem & Photobiology

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The aim of this study was to evaluate the photodynamic effect of Sinoporphyrin sodium (DVDMS). In this study, Eca-109 cells were treated with DVDMS (5 μg mL(-1)) and subjected to photodynamic therapy (PDT). The uptake and subcellular localization of DVDMS were monitored by flow cytometry and confocal microscopy. The phototoxicity of DVDMS was studied by MTT assay. The morphological changes were observed by scanning electron microscopy (SEM). DNA damage, reactive oxygen species (ROS) generation and mitochondria membrane potential (MMP) changes were analyzed by flow cytometry. Studies demonstrated maximal uptake of DVDMS occurred within 3 h, with a mitochondrial subcellular localization. MTT assays displayed that DVDMS could be effectively activated by light and the phototoxicity was much higher than photofrin under the same conditions. In addition, SEM observation indicated that cells were seriously damaged after PDT treatment. Furthermore, activation of DVDMS resulted in significant increases in ROS production. The generated ROS played an important role in the phototoxicity of DVDMS. DVDMS-mediated PDT (DVDMS-PDT) also induced DNA damage and MMP loss. It is demonstrated that DVDMS-mediated PDT is an effective approach on cell proliferation inhibition of Eca-109 cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antitumor Effect of Sinoporphyrin Sodium‐Mediated Photodynamic Therapy on Human Esophageal Cancer Eca‐109 Cells

Wang

Liu

et al. 2014

Photochem & Photobiology

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“…A secondgeneration of PS has been then developed, with improved purity, longer wavelength absorptions and higher photosensitivity and tissue selectivity. Temoporfin was the second PS to receive approval and extensively used for treatment of advanced head and neck squamous cell carcinomas [115,116] . Temoporfin was also tried for the treatment of breast, pancreatic and prostatic cancer [117][118][119][120][121] , with mixed results.…”

Section: Clinical Applications Of Pdt; Combination With Other Therapimentioning

confidence: 99%

Photodynamic therapy in cancer treatment - an update review

Santos¹,

Almeida²,

Terra³

et al. 2019

JCMT

314

327

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Cancer remains a worldwide health problem, being the disease with the highest impact on global health. Even with all the recent technological improvements, recurrence and metastasis still are the main cause of death. Since photodynamic therapy (PDT) does not compromise other treatment options and presents reduced long-term morbidity when compared with chemotherapy or radiotherapy, it appears as a promising alternative treatment for controlling malignant diseases. In this review, we set out to perform a broad up-date on PDT in cancer research and treatment, discussing how this approach has been applied and what it could add to breast cancer therapy. We covered topics going from the photochemical mechanisms involved, the different cell death mechanisms being triggered by a myriad of photosensitizers up to the more recent-on-going clinical trials.Metastatic lesions are usually multiple and resistant to conventional therapies, jeopardizing successful surgical resection, chemo and radiation treatment [4] .Light has been known to provide a therapeutic potential for several thousands of years. Over 3000 years ago, since the Ancient, Indian and Chinese civilizations it has been used for the treatment of various diseases [5] mainly in combination with reactive chemicals, for example to treat conditions like vitiligo, psoriasis and skin cancer [6] . After 1895 with the discovery of the phototherapy, which rendered Niels Ryberg Finsen the Nobel prize in Physiology/Medicine in 1903 in recognition of his work on the treatment of diseases, and in particular on the treatment of lupus vulgaris by means of concentrated light rays, many studies with the use of light and chemicals emerged [7] .Photodynamic therapy (PDT) is currently being used as an alternative treatment for the control of malignant diseases [8][9][10] . It is based in the uptake of a photosensitizer (PS) molecule which, upon being excited by light in a determined wavelength, reacts with oxygen and generates oxidant species (radicals, singlet oxygen, triplet species) in target tissues, leading to cell death [11,12] . PDT cytotoxic properties have been established to be due to the oxidation of a large range of biomolecules in cells, including nucleic acids, lipids, and proteins, leading to severe alteration in cell signaling cascades or in gene expression regulation [13,14] . Like all the newly proposed treatments, there is still place for improvements and lots of resources have been invested in this field recently. In this review, we set out to perform a broad up-date on PDT and it implication in cancer research and treatment. We have covered topics going from the photochemical mechanisms involved, the different cell death mechanisms being triggered by a myriad of photosensitizers up to the more recent reported preclinical studies and on-going clinical trials. PHOTOCHEMICAL PRINCIPLES AND COMPONENTS OF PDTAs previously stated, PDT involves the photosensitized oxidation of biomolecules which can be separated in two mechanisms. In Type I, light energy passes from exc...

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“…Two of three patients with laryngeal SCC (66.7%) irradiated at 200 J/cm 2 developed vocal cords adhesion after PDT as a serious adverse event; both patients complained of dyspnea and required tracheotomies, laser incision, and silicon plate insertion between the anterior vocal cords for treatment. Airway swelling is also a common complication following PDT for laryngeal tumors; stenosis has previously been reported to occur after PDT, although the quality of care that the patients received during these episodes is unclear . After experiencing our two aforementioned patients, we now perform tracheotomy prior to PDT in patients with laryngeal SCC, and reduce the PDT power from 200 to 80–100 J/cm 2 to prevent dyspnea.…”

Section: Discussionmentioning

confidence: 99%