Strategies for Surface Design in Surface Plasmon Resonance (SPR) Sensing

Abstract

Surface plasmon resonance (SPR) comprises several surface-sensitive techniques that enable the trace and ultra-trace detection of various analytes through affinity pairing. Although enabling label-free, sensitive detection and real-time monitoring, several issues remain to be addressed, such as poor stability, non-specific adsorption and the loss of operational activity of biomolecules. In this review, the progress over sensor modification, immobilization techniques and novel 2D nanomaterials, gold nanostructures and magnetic nanoparticles for signal amplification is discussed. The advantages and disadvantages of each design strategy will be provided together with some of the recent achievements.

Biosensing Platforms for Cardiac Biomarker Detection

“…Despite these limitations, SPR biosensors continue to be highly valuable in various research and diagnostic applications. Researchers and developers should consider these disadvantages when selecting the most appropriate biosensor technology for their specific needs and design experiments to address potential challenges. , …”

“…Researchers and developers should consider these disadvantages when selecting the most appropriate biosensor technology for their specific needs and design experiments to address potential challenges. 154,155 Dutra et al utilized an SPR biosensor for the real-time and rapid detection of human troponin T. They improved the SPR biosensor by using a streptavidin-terminated self-assembled monolayer to immobilize biotinylated antitroponin T monoclonal antibodies. The result of this assay demonstrated that the improved SPR biosensor had a detection range for troponin T of 0.03 to 6.5 ng/mL.…”

Bandwidth of quantized surface plasmons: competition between radiative and nonradiative damping effects

“…4–10 LSPR has found numerous applications in diverse fields, including photonics, chemistry, medicine, and energy harvesting. 11–14 The full width at half maximum (FWHM) of LSPR is an important parameter that should be carefully optimized for specific device-based applications. 11–17 A narrower resonance peak is required for more precise real-time sensing and accurate analyte detection.…”

“…11–14 The full width at half maximum (FWHM) of LSPR is an important parameter that should be carefully optimized for specific device-based applications. 11–17 A narrower resonance peak is required for more precise real-time sensing and accurate analyte detection. 11,16 In contrast, a broad FWHM can be advantageous for LSPR-based energy conversion applications.…”

“…11,16 In contrast, a broad FWHM can be advantageous for LSPR-based energy conversion applications. 13,14 Therefore, understanding the factors that determine the bandwidth of LSPR and being able to fine-tune its FWHM are essential for achieving the necessary performance characteristics for any particular LSPR-based application.…”