Strategies for optimising musculoskeletal health in the 21st century

Abstract

We live in a world with an ever-increasing ageing population. Studying healthy ageing and reducing the socioeconomic impact of age-related diseases is a key research priority for the industrialised and developing countries, along with a better mechanistic understanding of the physiology and pathophysiology of ageing that occurs in a number of age-related musculoskeletal disorders. Arthritis and musculoskeletal disorders constitute a major cause of disability and morbidity globally and result in enormous costs for our health and social-care systems. By gaining a better understanding of healthy musculoskeletal ageing and the risk factors associated with premature ageing and senescence, we can provide better care and develop new and better-targeted therapies for common musculoskeletal disorders. This review is the outcome of a two-day multidisciplinary, international workshop sponsored by the Institute of Advanced Studies entitled "Musculoskeletal Health in the 21st Century" and held at the University of Surrey from 30th June-1st July 2015. The aim of this narrative review is to summarise current knowledge of musculoskeletal health, ageing and disease and highlight strategies for prevention and reducing the impact of common musculoskeletal diseases.

Correlation of Age and Bone Marrow Derived CD 34+ Cells and Leucocytes in 873 Patients.

“…Arthritis and musculoskeletal disorders constitute a major cause of disability and the burden of musculoskeletal diseases will increase with an increasing ageing population. 22 Stem cells remain at the forefront of efforts in Regenerative Medicine, based on a conviction that this technology can provide an effective treatment paradigm for major diseases where there is still an unmet need. 3 In 2017 the rst prospective, single blind, placebo-controlled trial of bone marrow aspirate concentrate for knee osteoarthritis described a positive clinical outcome.…”

What to Expect: Medical Quality Outcomes and Achievements of a Multidisciplinary Inpatient Musculoskeletal System Rehabilitation

“…The medical outcome parameters required by the performance profile of the federal Austrian social security institutions involved in quantifying the quality of rehabilitation outcomes are the basis of this work. We provide descriptive standardized numeric indicators of the rehabilitation process as well as monocentric reference data for a 3 Table 2).…”

“…The majority of patients were admitted for rehabilitation due to back pain (29.6%) followed by upper/lower limb joint as well as knee (21.4%), hip (16.3%) and shoulder (12.0%) disorders. About 73.3% of the patients were admitted after surgery (OP) 3 . Just under a half of those patients (42.2%) were treated with an endoprosthesis (EP) (overall, 31.9%).…”

“…Special care in rehabilitation is given to the ailments of the modern society. As such, especially risk factors like sedentary behavior 1 , physical inactivity, overeating causing obesity, alcohol abuse and smoking leading to various chronic diseases that immediately affect the musculoskeletal system [3] are causes for concern. Due to those lifestyle choices that lead to potentially life-threatening conditions, physical activity has become an important therapeutic approach.…”

Health Evaluation in the Context of Satisfaction with Medical Services among Patients with Osteoarthritis: Descriptive Cross-Section Survey

“…With time, some depressions and fissures become visible on the surface of the cartilage. Advanced (OA) is characterized by complete destruction of cartilage and exposure of the articular surface [8][9][10]. The World Health Organization (WHO) states that OA symptoms occur in 9.6% of the world male population and 18% of the world female population at the age of 60.…”