Strategies for Improving the Repair of Focal Cartilage Defects

Abdel-Sayed, Philippe; Pioletti, Dominique P.

doi:10.2217/nnm.15.119

Cited by 20 publications

(19 citation statements)

References 104 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This technology exploits the multipotent capability of stem cells and accomplishes cartilage repair at low cost and with little surgical damage. However, the method causes fibrous cartilage formation in the repaired tissue, rather than the hyaline cartilage found in normal articular cartilage, which affects the biological performance [ 4 , 100 ].…”

Section: Regenerative Medicine In Cartilage Repairmentioning

confidence: 99%

Advances and Prospects in Stem Cells for Cartilage Regeneration

Wang

Yuan

et al. 2017

Stem Cells International

View full text Add to dashboard Cite

The histological features of cartilage call attention to the fact that cartilage has a little capacity to repair itself owing to the lack of a blood supply, nerves, or lymphangion. Stem cells have emerged as a promising option in the field of cartilage tissue engineering and regenerative medicine and could lead to cartilage repair. Much research has examined cartilage regeneration utilizing stem cells. However, both the potential and the limitations of this procedure remain controversial. This review presents a summary of emerging trends with regard to using stem cells in cartilage tissue engineering and regenerative medicine. In particular, it focuses on the characterization of cartilage stem cells, the chondrogenic differentiation of stem cells, and the various strategies and approaches involving stem cells that have been used in cartilage repair and clinical studies. Based on the research into chondrocyte and stem cell technologies, this review discusses the damage and repair of cartilage and the clinical application of stem cells, with a view to increasing our systematic understanding of the application of stem cells in cartilage regeneration; additionally, several advanced strategies for cartilage repair are discussed.

show abstract

Section: Regenerative Medicine In Cartilage Repairmentioning

confidence: 99%

Advances and Prospects in Stem Cells for Cartilage Regeneration

Wang

Yuan

et al. 2017

Stem Cells International

View full text Add to dashboard Cite

show abstract

“…Osteochondral interface defects generally involve lesions in articular cartilage and subchondral cartilage. Cartilage is essentially avascular and less cellular, and lacks the ability to repair itself (Abdel-Sayed and Pioletti, 2015). Meanwhile, if cartilage defects are not treated, joints will gradually and irrevocably deteriorate, leading to severe osteoarthritis and eventually disability (Chen et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Advances of Stem Cell-Laden Hydrogels With Biomimetic Microenvironment for Osteochondral Repair

Yuan

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Osteochondral damage from trauma or osteoarthritis is a general joint disease that can lead to an increased social and economic burden in the modern society. The inefficiency of osteochondral defects is mainly due to the absence of suitable tissue-engineered substrates promoting tissue regeneration and replacing damaged areas. The hydrogels are becoming a promising kind of biomaterials for tissue regeneration. The biomimetic hydrogel microenvironment can be tightly controlled by modulating a number of biophysical and biochemical properties, including matrix mechanics, degradation, microstructure, cell adhesion, and intercellular interactions. In particular, advances in stem cell-laden hydrogels have offered new ideas for the cell therapy and osteochondral repair. Herein, the aim of this review is to underpin the importance of stem cell-laden hydrogels on promoting the development of osteochondral regeneration, especially in the field of manipulation of biomimetic microenvironment and utilization growth factors with various delivery methods.

show abstract

“…OAT implantation does not have the same limitations as other treatments in terms of time of rehabilitation and predictable cartilage-type results, and has become widely accepted as an effective treatment for high-grade AC defects of the knee and talus [ 10 , 11 , 12 ]. However, there are some limitations of OAT such as the increased morbidity rate at the donor site and high operation cost [ 6 , 13 , 14 ]. Thus, a biomedical engineering strategy was used to eliminate the limitations of the OAT technique for FTAC.…”

Section: Introductionmentioning

confidence: 99%

The 3D-Printed Bilayer’s Bioactive-Biomaterials Scaffold for Full-Thickness Articular Cartilage Defects Treatment

et al. 2020

View full text Add to dashboard Cite

The full-thickness articular cartilage defect (FTAC) is an abnormally severe grade of articular cartilage (AC) injury. An osteochondral autograft transfer (OAT) is the recommended treatment, but the increasing morbidity rate from osteochondral plug harvesting is a limitation. Thus, the 3D-printed bilayer’s bioactive-biomaterials scaffold is of major interest. Polylactic acid (PLA) and polycaprolactone (PCL) were blended with hydroxyapatite (HA) for the 3D-printed bone layer of the bilayer’s bioactive-biomaterials scaffold (B-BBBS). Meanwhile, the blended PLA/PCL filament was 3D printed and combined with a chitosan (CS)/silk firoin (SF) using a lyophilization technique to fabricate the AC layer of the bilayer’s bioactive-biomaterials scaffold (AC-BBBS). Material characterization and mechanical and biological tests were performed. The fabrication process consists of combining the 3D-printed structure (AC-BBBS and B-BBBS) and a lyophilized porous AC-BBBS. The morphology and printing abilities were investigated, and biological tests were performed. Finite element analysis (FEA) was performed to predict the maximum load that the bilayer’s bioactive-biomaterials scaffold (BBBS) could carry. The presence of HA and CS/SF in the PLA/PCL structure increased cell proliferation. The FEA predicted the load carrying capacity to be up to 663.2 N. All tests indicated that it is possible for BBBS to be used in tissue engineering for AC and bone regeneration in FTAC treatment.

show abstract

Strategies for Improving the Repair of Focal Cartilage Defects

Cited by 20 publications

References 104 publications

Advances and Prospects in Stem Cells for Cartilage Regeneration

Advances and Prospects in Stem Cells for Cartilage Regeneration

Advances of Stem Cell-Laden Hydrogels With Biomimetic Microenvironment for Osteochondral Repair

The 3D-Printed Bilayer’s Bioactive-Biomaterials Scaffold for Full-Thickness Articular Cartilage Defects Treatment

Contact Info

Product

Resources

About