Strategies for enhanced direct nose-to-brain drug delivery

Madav, Yamini; Wairkar, Sarika

doi:10.1016/b978-0-12-822522-6.00014-x

Cited by 4 publications

(3 citation statements)

References 78 publications

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“…also thank Michael Zachariadis (Material and Chemical Characterisation Facility, University of Bath) for his support with confocal microscopy, and Adam McAleer (School of Earth Sciences, University of Bristol) for his support of ICP-OES analysis. This article is based on Chapter 2 of Aida Maaz's PhD thesis, "Aerosolised Nanoparticles for Nose-to-Brain Drug Delivery (NTBDD)" [67].…”

Section: Discussionmentioning

confidence: 99%

Gold Nanoparticles: Tunable Characteristics and Potential for Nasal Drug Delivery

Maaz,

Blagbrough,

De Bank

2024

Pharmaceutics

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A general procedure to prepare gold nanourchins (GNUs) via a seed-mediated method was followed using dopamine hydrochloride as a reducing agent and silver nitrate salt (AgNO3) as a shape-directing agent. The novelty of this study comes from the successful incorporation of the prepared gold urchins as an aqueous suspension in a nasal pressurized metered dose inhaler (pMDI) formulation and the investigation of their potential for olfactory targeting for direct nose-to-brain drug delivery (NTBDD). The developed pMDI formulation was composed of 0.025% w/w GNUs, 2% w/w Milli-Q water, and 2% w/w EtOH, with the balance of the formulation being HFA134a propellant. Particle integrity and aerosolization performance were examined using an aerosol exposure system, whereas the nasal deposition profile was tested in a sectioned anatomical replica of human nasal airways. The compatibility of the gold dispersion with the nasal epithelial cell line RPMI 2650 was also investigated in this study. Colloidal gold was found to be stable following six-month storage at 4 °C and during the lyophilization process utilizing a pectin matrix for complete re-dispersibility in water. The GNUs were intact and discrete following atomization via a pMDI, and 13% of the delivered particles were detected beyond the nasal valve, the narrowest region in the nasal cavity, out of which 5.6% was recovered from the olfactory region. Moreover, the formulation was found to be compatible with the human nasal epithelium cell line RPMI 2650 and excellent cell viability was observed. The formulated GNU-HFA-based pMDI is a promising approach for intranasal drug delivery, including deposition in the olfactory region, which could be employed for NTBDD applications.

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Section: Discussionmentioning

confidence: 99%

Gold Nanoparticles: Tunable Characteristics and Potential for Nasal Drug Delivery

Maaz,

Blagbrough,

De Bank

2024

Pharmaceutics

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“…Nasal and oromucosal drug delivery is a contemporary field of research, mostly because of the multiple advantages they offer beyond their most commercial designation—to treat and/or protect the mucosa. The nasal route stands out as one of the most prospective sites for peptide and protein delivery [ 195 ], and direct brain drug delivery (via the olfactory bulb) [ 196 , 197 ]; the buccal route reveals opportunities for sustained drug delivery, and the sublingual route allows fast access to the systemic circulation [ 198 , 199 ]; both the nasal and the oromucosal routes are eligible for mucosal vaccination, for which target zones are the lymphoid regions (NALT and MALT, respectively) [ 65 , 200 , 201 , 202 , 203 ]. However, in the light of the current topic, the focus will be directed to nasal and oromucosal drug administration for local protection.…”

Section: The Nasal and Oromucosal Drug Deliverymentioning

confidence: 99%

Advances in the Prophylaxis of Respiratory Infections by the Nasal and the Oromucosal Route: Relevance to the Fight with the SARS-CoV-2 Pandemic

et al. 2022

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In this time of COVID-19 pandemic, the strategies for prevention of the infection are a primary concern. Looking more globally on the subject and acknowledging the high degree of misuse of protective face masks from the population, we focused this review on alternative pharmaceutical developments eligible for self-defense against respiratory infections. In particular, the attention herein is directed to the nasal and oromucosal formulations intended to boost the local immunity, neutralize or mechanically “trap” the pathogens at the site of entry (nose or mouth). The current work presents a critical review of the contemporary methods of immune- and chemoprophylaxis and their suitability and applicability in topical mucosal dosage forms for SARS-CoV-2 prophylaxis.

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“…Lipid nanoparticles, including liposomes, niosomes, nanoemulsions and solid lipid nanoparticles (SLNs), are among the most promising drug delivery systems because of their biocompatible nature [8][9][10]. Moreover, these nanosystems can provide protection of the embedded active pharmaceutical ingredient (API) against efflux transporters (Pglycoprotein), enzymatic degradation or chemical destabilization at nasal conditions [11].…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of n-Propyl Gallate Encapsulated Solid Lipid Nanoparticles-Loaded Hydrogel for Intranasal Delivery

et al. 2021

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The objective of the present study was to develop n-propyl gallate-loaded solid lipid nanoparticles (PG-SLNs) in a hydrogel (HG) formulation using Transcutol-P (TC-P) as a permeation enhancer. Modified solvent injection technique was applied to produce optimized PG-SLNs via the Quality by Design approach and central composite design. The in vitro mucoadhesion, scavenging activity, drug release, permeation studies of PG from PG-SLNs-loaded HG were evaluated under simulated nasal conditions. Compared with in vitro release behavior of PG from SLNs, the drug release from the PG-SLNs-loaded HG showed a lower burst effect and sustained release profile. The cumulative permeation of PG from PG-SLNs-loaded HG with TC-P was 600 μg/cm2 within 60 min, which is 3–60-fold higher than PG-SLNs and native PG, respectively. Raman mapping showed that the distribution of PG-SLNs was more concentrated in HG having lower concentrations of hyaluronic acid. The scavenging assay demonstrated increased antioxidant activity at higher concentrations of HG. Due to enhanced stability and mucoadhesive properties, the developed HG-based SLNs can improve nasal absorption by increasing residence time on nasal mucosa. This study provides in vitro proof of the potential of combining the advantages of SLNs and HG for the intranasal delivery of antioxidants.

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Strategies for enhanced direct nose-to-brain drug delivery

Cited by 4 publications

References 78 publications

Gold Nanoparticles: Tunable Characteristics and Potential for Nasal Drug Delivery

Gold Nanoparticles: Tunable Characteristics and Potential for Nasal Drug Delivery

Advances in the Prophylaxis of Respiratory Infections by the Nasal and the Oromucosal Route: Relevance to the Fight with the SARS-CoV-2 Pandemic

Development and Characterization of n-Propyl Gallate Encapsulated Solid Lipid Nanoparticles-Loaded Hydrogel for Intranasal Delivery

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