Strategies for Effective Neural Circuit Reconstruction After Spinal Cord Injury: Use of Stem Cells and Biomaterials

Hou, Yuanyuan; Liu, Xiaoxia; Guo, Ying; Liu, Dandan; Guo, Peiyun; Liu, Jiamei

doi:10.1016/j.wneu.2022.02.012

Cited by 15 publications

(11 citation statements)

References 72 publications

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“…Hydrogels can also provide support for the injured spinal cord, form a local bridge for nerve regeneration and prevent scar formation, and the 3D porous structure provides a matrix for supporting tissue implantation ( Tsintou et al, 2015 ). Currently, hydrogels used for spinal cord injury repair include natural hydrogels such as alginate, agarose, collagen, fibronectin, gelatin, and ECM, as well as synthetic hydrogels such as polylactic acid, polylactic acid-ethanolic acid, and polyethylene glycol ( Hou et al, 2022 ).…”

Section: Various Forms Of Biomaterials Scaffoldsmentioning

confidence: 99%

“…3D bioprinting technology is a technology based on biomaterial scaffolds, cells and other biologically active molecules, which can accurately and efficiently simulate complex and personalized bionic functional scaffolds. 3D bioprinting technology has been applied to a variety of tissues including bone, cartilage, vascular systems, muscle and heart, but there are relatively few studies regarding SCI ( Koffler et al, 2019 ; Sun et al, 2019 ; Hou et al, 2022 ).…”

Section: Various Forms Of Biomaterials Scaffoldsmentioning

confidence: 99%

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Exosomes combined with biomaterials in the treatment of spinal cord injury

Zhang

Jiang

et al. 2023

Front. Bioeng. Biotechnol.

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Spinal cord injury (SCI) is a serious and disabling disease with a high mortality rate. It often leads to complete or partial sensory and motor dysfunction and is accompanied by a series of secondary outcomes, such as pressure sores, pulmonary infections, deep vein thrombosis in the lower extremities, urinary tract infections, and autonomic dysfunction. Currently, the main treatments for SCI include surgical decompression, drug therapy, and postoperative rehabilitation. Studies have shown that cell therapy plays a beneficial role in the treatment of SCI. Nonetheless, there is controversy regarding the therapeutic effect of cell transplantation in SCI models. Meanwhile exosomes, as a new therapeutic medium for regenerative medicine, possess the advantages of small size, low immunogenicity, and the ability to cross the blood-spinal cord barrier. Certain studies have shown that stem cell-derived exosomes have anti-inflammatory effects and can play an irreplaceable role in the treatment of SCI. In this case, it is difficult for a single treatment method to play an effective role in the repair of neural tissue after SCI. The combination of biomaterial scaffolds and exosomes can better transfer and fix exosomes to the injury site and improve their survival rate. This paper first reviews the current research status of stem cell-derived exosomes and biomaterial scaffolds in the treatment of SCI respectively, and then describes the application of exosomes combined with biomaterial scaffolds in the treatment of SCI, as well as the challenges and prospects.

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Section: Various Forms Of Biomaterials Scaffoldsmentioning

confidence: 99%

Section: Various Forms Of Biomaterials Scaffoldsmentioning

confidence: 99%

Exosomes combined with biomaterials in the treatment of spinal cord injury

Zhang

Jiang

et al. 2023

Front. Bioeng. Biotechnol.

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“…Combinatorial treatments have been developed based on the complex pathophysiological changes after SCI. These approaches involve the delivery of a combination of biomaterials and cells or soluble molecules to the site of injury ( Hou et al, 2022 ). The combination of biomaterial scaffolds and the transplantation of mesenchymal stem cells promotes the formation of connections between multiple cells during the pathological process after SCI ( Papa et al, 2020 ).…”

Section: Approaches For Spinal Cord Injury Treatmentmentioning

confidence: 99%

Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment

Yang

Pan

Wang

et al. 2022

Front. Cell. Neurosci.

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Spinal cord injury (SCI) is a serious neurological trauma that is challenging to treat. After SCI, many neurons in the injured area die due to necrosis or apoptosis, and astrocytes, oligodendrocytes, microglia and other non-neuronal cells become dysfunctional, hindering the repair of the injured spinal cord. Corrective surgery and biological, physical and pharmacological therapies are commonly used treatment modalities for SCI; however, no current therapeutic strategies can achieve complete recovery. Somatic cell reprogramming is a promising technology that has gradually become a feasible therapeutic approach for repairing the injured spinal cord. This revolutionary technology can reprogram fibroblasts, astrocytes, NG2 cells and neural progenitor cells into neurons or oligodendrocytes for spinal cord repair. In this review, we provide an overview of the transcription factors, genes, microRNAs (miRNAs), small molecules and combinations of these factors that can mediate somatic cell reprogramming to repair the injured spinal cord. Although many challenges and questions related to this technique remain, we believe that the beneficial effect of somatic cell reprogramming provides new ideas for achieving functional recovery after SCI and a direction for the development of treatments for SCI.

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“…Biomimetic scaffolds, biomaterials, cells and other bioactive molecules can be created accurately and efficiently by using them as units. By creating a personalized bionic 3D scaffold to simulate the diverse tissue microenvironment, proliferation and differentiation of stem cells can be induced (25). The biomaterial will transmit specific signals to the cells, especially depending on their composition and structure.…”

Section: Biomaterialsmentioning

confidence: 99%

“…Ideal bio-ink has high mechanical integrity, high stability, insoluble in cell culture medium, nontoxic and non-immunogenic; and should be able to promote cell adhesion (38). 3D bioprinting technology is based on biomaterials, cells and other bioactive molecules as units that can accurately and efficiently form complex bionic functional scaffolds (25). 3D stem cell culture can use a variety of matrices or scaffolds in addition to cells to support complex structures (10)…”

Section: Stem Cell and 3d Bioprintingmentioning

confidence: 99%

Stem cell and biomaterials

Demir¹

2022

J Exp Clin Med

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Stem cells are cells that are not yet differentiated, can divide asymmetrically, differentiate into different cell types, and perform functional tissue repair. They are recognized as major cellular candidates for the regeneration of damaged tissues. Biomaterials and biomaterial scaffolds are essential in tissue engineering applications using stem cells. Recently, studies examining stem cell biomaterial interactions in different aspects have attracted attention. This review presents current information about the general properties of stem cells and biomaterials, stem cellbiomaterial interactions, three-dimensional (3D) tissue scaffolds used in stem cell studies, and 3D bioprinting.

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Strategies for Effective Neural Circuit Reconstruction After Spinal Cord Injury: Use of Stem Cells and Biomaterials

Cited by 15 publications

References 72 publications

Exosomes combined with biomaterials in the treatment of spinal cord injury

Exosomes combined with biomaterials in the treatment of spinal cord injury

Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment

Stem cell and biomaterials

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