Strategic white matter injury associated with long‐term information processing speed deficits in mild traumatic brain injury

Bai, Lijun; Bai, Guanghui; Wang, Shan; Yang, Xinyi; Gan, Shuoqiu; Jia, Xiaoyan; Yin, Bo; Yan, Zhihan

doi:10.1002/hbm.25135

Cited by 34 publications

(18 citation statements)

References 63 publications

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“…Similarly, our previous review has demonstrated that depression and anxiety are associated with elevated TNF-α, IL-6, IFN-α, and C-Reactive Protein (CRP) levels [ 9 ]. Overall, the most common systemic cytokines associated with mTBI include IL-6 [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ], TNF-α [ 20 , 23 , 24 , 25 ], IL-10 [ 20 , 26 ], IL-1β [ 19 , 20 ], Interleukin-8 (IL-8) [ 20 , 25 ], Interferon Gamma (IFN-γ) [ 20 , 25 ], Interleukin-1RA (IL-1RA) [ 17 , 21 ], Interleukin-4 (IL-4) [ 20 ], and C–C motif chemokine ligand 2 (CCL2) [ 19 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review

et al. 2022

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Both mild traumatic brain injuries (mTBI) and systemic injuries trigger a transient neuroinflammatory response that result in similar clinical outcome. The ensuing physical, cognitive, and emotional symptoms fail to subside in approximately 15–20% of the concussed population. Emotional impairments, particularly depression, anxiety, and post-traumatic stress disorder (PTSD), are commonly associated with poor recovery following mTBI. These emotional impairments also have a significant neuroinflammatory component. We hypothesized that the inflammatory cytokines seen in mTBI patients with emotional symptoms would coincide with those commonly seen in patients with emotional symptoms without mTBI. A systematic review was conducted to identify the most common neuroinflammatory cytokines in the mTBI population with psychological symptoms (depression, anxiety, PTSD). The electronic databases EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), PUBMED, and PSYCINFO were searched from data inception to 31 August 2021. A systematic screening approach was employed from screening to data analysis. A total of 994 articles were screened, 108 were selected for full article review, and 8 were selected for data analysis. The included studies consisted of 875 patients of which 81.3% were male. The mean sample size of patients with at least one mTBI was 73.8 ± 70.3 (range, 9–213), with a mean age of 33.9 ± 4.8 years. The most common cytokines associated with poor psychological outcomes involving PTSD and/or depression in the chronic mTBI population were IL-6, TNFα, IL-10, and CRP.

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Section: Introductionmentioning

confidence: 99%

Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review

et al. 2022

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“…Recently, more and more studies focused on the development of a predictive modal to find out potential diffusion biomarkers and to detect mTBI patients based on machine learning ( Vergara et al, 2017 ). As a recent prediction modal that can identify mTBI patients by developing information processing speed deficits with 96.7% accuracy through the combination of DTI indices and inflammation cytokines levels, the frontal-subcortical neuronal circuits would be a potential diffusion predictor for processing speed performance in mTBI patients ( Bai et al, 2020 ). Compared to these prediction modals, the differential tractography would be an indispensable complementary tool to evaluate axonal loss for individual mTBI patients.…”

Section: Discussionmentioning

confidence: 99%

Differential Tractography and Correlation Tractography Findings on Patients With Mild Traumatic Brain Injury: A Pilot Study

Yeh

Huang

et al. 2022

Front. Hum. Neurosci.

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Differential tractography and correlation tractography are new tractography modalities to study neuronal changes in brain diseases, but their performances in detecting neuronal injuries are yet to be investigated in patients with mild traumatic brain injury (mTBI). Here we investigated the white matter injury in mTBI patients using differential and correlation tractography. The diffusion MRI was acquired at 33 mTBI patients and 31 health controls. 7 of the mTBI patients had one-year follow-up scans, and differential tractography was used to evaluate injured fiber bundles on these 7 patients. All subjects were evaluated using digital symbol substitution test (DSST) and trail making test A (TMT-A), and the correlation tractography was performed to explore the exact pathways related to the cognitive performance. Our results showed that differential tractography revealed neuronal changes in the corpus callosum in all 7 follow-up mTBI patients with FDR between 0.007 and 0.17. Further, the correlation tractography showed that the splenium of the corpus callosum, combined with the right superior longitudinal fasciculus and right cingulum, were correlated with DSST (FDR = 0.001669) in the acute mTBI patients. The cognitive impairment findings in the acute stage and the longitudinal findings in the corpus callosum in the chronic stage of mTBI patients suggest that differential tractography and correlation tractography are valuable tools in the diagnostic and prognostic evaluation of neuronal injuries in mTBI patients.

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“…Two-thirds of all concussions occur in children, with 20-40% reporting at least one concussion by the time they reach adolescence. 1–3 Concussion symptoms include cognitive impairment, prominently problems with attention and processing speed, 4–7 along with emotional and physical problems, and sleep dysregulation all of which can impact academic performance and overall quality of life. 8–10 Most children that experience a concussion recover within two weeks of injury, however, 10-30% of children experience symptoms that last longer than 3 months, 11–13 with females at greater risk of persistent symptoms.…”

Section: Introductionmentioning

confidence: 99%

Premature white matter microstructure in female children with a history of concussion

Nishat

Stojanovski

Scratch

et al. 2021

Preprint

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As maturation of the brain continues throughout development, there is a risk of interference from concussions which are common in childhood. A concussion can cause widespread disruption to axons and inflammation in the brain and may influence emerging cognitive abilities. Females are more likely to experience persistent problems after a concussion, yet the sex-specific impact of concussions on brain microstructure in childhood is not well understood.In children from a large population sample, this study (1) investigated differences in white matter and cortical microstructure between children with and without a history of concussion, and (2) examined relationships between altered brain microstructure and cognitive performance.Neurite density measures from diffusion weighted magnetic resonance imaging were examined in 9-to 10-year-old children in the Adolescent Brain Cognitive Development Study with (n = 336) and without (n = 7368) a history of concussion. (1) Multivariate regression models were used to investigate the relationships between concussion history, sex, and age in the deep white matter, superficial white matter, subcortical structures, and cortex. (2) Principal component analysis was performed on neurite density, and components were examined in relation to performance on the Flanker Inhibitory Control and Attention Task and the Pattern Comparison Processing Speed Task to investigate the relationship between altered neurite density and cognitive performance.Neurite density in all tissue types demonstrated robust positive relationships with age reflecting maturation of brain microstructure. (1) Comparisons between children with and without a history of concussion revealed higher neurite density in deep and superficial white matter in females with concussion. No group differences were observed in subcortical or cortical neurite density. (2) Higher neurite density in superficial white matter beneath the frontal and temporal cortices was associated with lower scores on the processing speed test in females with concussion, and higher scores on the processing speed test in males with concussion.These findings suggest that concussion in childhood leads to premature white matter maturation in females and that this may be associated with slower processing speed. These sex-specific effects on the developing brain may contribute to the enhanced vulnerability to persistent symptoms after concussion in females.

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Strategic white matter injury associated with long‐term information processing speed deficits in mild traumatic brain injury

Cited by 34 publications

References 63 publications

Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review

Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review

Differential Tractography and Correlation Tractography Findings on Patients With Mild Traumatic Brain Injury: A Pilot Study

Premature white matter microstructure in female children with a history of concussion

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