Premature white matter microstructure in female children with a history of concussion

Nishat, Eman; Stojanovski, Sonja; Scratch, Shannon E.; Ameis, Stephanie H.; Wheeler, Anne L.

doi:10.1101/2021.12.02.21267220

Cited by 2 publications

(1 citation statement)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 demonstrate the general compatibility of the proposal ISF-Axon interaction theory in the ovine brain WM as different configurations of microstructure reached the same trend of pressure-permeability relationship. The emergence of high-resolution imaging techniques has made it possible to also obtain microstructural information of the human brain [63,64], thus the protocol proposed in this study can be also used to gain a deeper understanding of ISF-Axon interaction and fluid/mass transport in the human brain. In addition, Figs.…”

Section: Discussionmentioning

confidence: 99%

Linking fluid-axons interactions to the macroscopic fluid transport properties of the brain

Yuan

Zhan²,

Dini

2023

Preprint

View full text Add to dashboard Cite

Many brain disorders, including Alzheimer's Disease and Parkinson's Disease, and drug delivery procedures are linked to fluid transport in the brain; yet, while neurons are extremely soft and can be easily deformed, how the microscale channel flow interacts with the neuronal structures (especially axons) deformation and how these interactions affect the macroscale tissue function and transport properties is poorly understood. Misrepresenting these relationships may lead to the erroneous prediction of e.g. disease spread, drug delivery, and nerve injury in the brain. However, understanding fluid-neuron interactions is an outstanding challenge because the behaviours of both phases are not only dynamic but also occur at an extremely small length scale (the width of the flow channel is ∼100 nm), which cannot be captured by the state-of-the-art experimental techniques. Here, by explicitly simulating dynamics of the flow and axons at the microstructural level, we, for the first time, establish the link between micromechanical tissue response to the physical laws governing the macroscopic transport property of the brain white matter. We found that interactions between axons and the interstitial flow are very strong, thus playing an essential role in the brain fluid/mass transport. Furthermore, we proposed the first anisotropic pressure-dependent permeability tensor informed by microstructural dynamics for more accurate brain modelling at the macroscale, and analysed the effect of the variation of the microstructural parameters that influence such tensor. These findings will sheds light on some unsolved issues linked to brain functions and medical treatments relying on intracerebral transport, and the mathematical model provides a framework to more realistically model the brain and design the brain-tissue-like biomaterials.

show abstract

Section: Discussionmentioning

confidence: 99%

Linking fluid-axons interactions to the macroscopic fluid transport properties of the brain

Yuan

Zhan²,

Dini

2023

Preprint

View full text Add to dashboard Cite

show abstract

Disrupted maturation of white matter microstructure after concussion contributes to internalizing behavior problems in female children

Nishat

Scratch

Ameis

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Some children that experience a concussion exhibit long-lasting emotional and behavioral problems post injury, with greater rates of persistent problems in females. Establishing the contribution of (1) pre-existing behavioral problems and (2) disrupted maturation of the brain′s vulnerable white matter, to long-lasting behavioral problems has been a challenge due to a lack of pre-injury behavioral and imaging data. From the Adolescent Brain Cognitive Development Cohort, this study examined 204 11-12-year-old children who experienced a concussion after baseline data collection at age 9-10-years-old. Internalizing and externalizing behavioral problems were assessed with the Child Behavior Checklist. In 99 of these children with MRI data available, white matter microstructure was characterized in deep and superficial white matter by neurite density from restriction spectrum image modeling of diffusion MRI. Linear regressions modeled 1) post-concussion behavior symptoms controlling for pre-injury behavior, 2) the impact of concussion on white matter maturation, and 3) the contribution of deviations in white matter maturation to post-concussion behavior symptoms. When controlling for pre-injury scores, post-injury internalizing and externalizing scores were higher in female but not male children with concussion compared to children with no concussion. Group comparisons of change in neurite density over two years reflecting white matter maturation demonstrated an age-dependent effect whereby younger female children had less change in neurite density over time than younger children with no concussion. In female children with concussion, less change in superficial white matter neurite density over time was associated with more internalizing behavior problems. These results suggest that in female children, concussions are associated with behavior problems beyond those that exist pre-injury, and injury to the brain's vulnerable white matter may be a biological substrate underlying persistent internalizing behaviors.

show abstract

Premature white matter microstructure in female children with a history of concussion

Cited by 2 publications

References 85 publications

Linking fluid-axons interactions to the macroscopic fluid transport properties of the brain

Linking fluid-axons interactions to the macroscopic fluid transport properties of the brain

Disrupted maturation of white matter microstructure after concussion contributes to internalizing behavior problems in female children

Contact Info

Product

Resources

About