Strain energy density as a rupture criterion for the kidney: impact tests on porcine organs, finite element simulation, and a baseline comparison between human and porcine tissues

Snedeker, Jess G.; Barbezat, Michel; Niederer, Peter F.; Schmidlin, F.; Farshad, M.

doi:10.1016/j.jbiomech.2004.05.030

Cited by 65 publications

(48 citation statements)

References 16 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For all the studied strains, energy and pressure, 0.265 MPS, 0.281 MSS, and 1.72E−6 (J/mm 3 ) SED were found to be appropriate to predict the contusion volume with minimum residual error. Snedeker et al [32] used SED to predict the rupture of kidney. Shreiber et al [14] investigated stresses besides strains and SED.…”

Section: Discussionmentioning

confidence: 99%

Investigation of brain contusion mechanism and threshold by combining finite element analysis with in vivo histology data

Mao

Yang

2011

Numer Methods Biomed Eng

View full text Add to dashboard Cite

SUMMARYA previously validated, highly detailed three-dimensional finite element (FE) rat brain model was used to correlate FE model-predicted intracranial responses with experimentally measured brain contusions. In the published in vivo experimental study, the animals were injured via a controlled cortical impact device at two different severities and the location and volume of contusion measured at 24 h post injury. Brain internal responses, including the maximum principal strain (MPS), maximum shear strain (MSS), shear strain (SS) in the coronal plane, strain energy density (SED), and intracranial pressure (ICP), were investigated through FE simulations. Distributions of MPS, MSS, and SED were comparable with the shapes of contusion observed experimentally. However, the regions with high positive ICP were not found to correlate with the regions of brain contusion. Locations of high SS were in the vicinity of the experimental contusion region, but the shallow shape of the SS distribution differed greatly from contusion observed experimentally. This study suggests that MPS, MSS, and SED are candidate injury mechanisms for brain contusion, and the corresponding threshold for predicting the contusion volume measured at 24 h post injury is 0.265 MPS, 0.281 MSS, or 1.72E−5 (J/mm 3 ) SED based on the current FE model.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigation of brain contusion mechanism and threshold by combining finite element analysis with in vivo histology data

Mao

Yang

2011

Numer Methods Biomed Eng

View full text Add to dashboard Cite

show abstract

“…Average contact pressures were calculated by dividing the cumulative normal force (element contact stress multiplied by element area) for elements in contact by the total contact area as described above. Peak pressures were calculated from elements sharing the node with highest normal contact force (the cumulative normal force divided by the cumulative area of the elements 23 ).…”

Section: Model Validationmentioning

confidence: 99%

Misalignment of Total Ankle Components Can Induce High Joint Contact Pressures

Espinosa

Wälti

Favre

et al. 2010

The Journal of Bone and Joint Surgery-American Volume

167

View full text Add to dashboard Cite

“…Brain, for example, has a Young modulus of several hundred pascals, whereas that of muscle lies above 10 kPa. Tissue from kidney has a value around 100 kPa and that of tendon and cartilage is in the range of megapascals (Levental et al, 2007;Georges et al, 2006;Snedeker et al, 2005;Discher et al, 2005). Only recently have proposals been made for more compliant materials that have tunable elasticity values that are comparable to living tissue.…”

Section: Selective and Uncoupled Role Of Substrate Elasticity In The mentioning

confidence: 99%

Selective and uncoupled role of substrate elasticity in the regulation of replication and transcription in epithelial cells

Kocgozlu

Lavalle

Koenig

et al. 2010

Journal of Cell Science

View full text Add to dashboard Cite

SummaryActin cytoskeleton forms a physical connection between the extracellular matrix, adhesion complexes and nuclear architecture. Because tissue stiffness plays key roles in adhesion and cytoskeletal organization, an important open question concerns the influence of substrate elasticity on replication and transcription. To answer this major question, polyelectrolyte multilayer films were used as substrate models with apparent elastic moduli ranging from 0 to 500 kPa. The sequential relationship between Rac1, vinculin adhesion assembly, and replication becomes efficient at above 200 kPa because activation of Rac1 leads to vinculin assembly, actin fiber formation and, subsequently, to initiation of replication. An optimal window of elasticity (200 kPa) is required for activation of focal adhesion kinase through auto-phosphorylation of tyrosine 397. Transcription, including nuclear recruitment of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), occurred above 50 kPa. Actin fiber and focal adhesion signaling are not required for transcription. Above 50 kPa, transcription was correlated with v-integrin engagement together with histone H3 hyperacetylation and chromatin decondensation, allowing little cell spreading. By contrast, soft substrate (below 50 kPa) promoted morphological changes characteristic of apoptosis, including cell rounding, nucleus condensation, loss of focal adhesions and exposure of phosphatidylserine at the outer cell surface. On the basis of our data, we propose a selective and uncoupled contribution from the substrate elasticity to the regulation of replication and transcription activities for an epithelial cell model.

show abstract

Strain energy density as a rupture criterion for the kidney: impact tests on porcine organs, finite element simulation, and a baseline comparison between human and porcine tissues

Cited by 65 publications

References 16 publications

Investigation of brain contusion mechanism and threshold by combining finite element analysis with in vivo histology data

Investigation of brain contusion mechanism and threshold by combining finite element analysis with in vivo histology data

Misalignment of Total Ankle Components Can Induce High Joint Contact Pressures

Selective and uncoupled role of substrate elasticity in the regulation of replication and transcription in epithelial cells

Contact Info

Product

Resources

About