Strain‐dependency of leukotriene C<sub>4</sub> generation from isolated lungs of immunized mice

Zuany-Amorim, Cláudia; Vargäftig, B. Boris; Maclouf, Jacques; Pretolani, Marina

doi:10.1111/j.1476-5381.1994.tb13215.x

Cited by 9 publications

(2 citation statements)

References 35 publications

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“…Treatment of the sensitized mice with recombinant murine (rm)IL-10, concurrently administered with ovalbumin, abrogates antigen-induced airway inflammation and TNF-a generation in the BAL fluid, suggesting that IL-10 plays an important role in regulating allergic inflammatory processes in the lung. IgE-like homocytotropic antibodies, as measured by passive cutaneous anaphylaxis ( 19). Bronchoalveolar cell counts and differentiation.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice.

Zuany-Amorim¹,

Hailé²,

Leduc³

et al. 1995

J. Clin. Invest.

250

166

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This report examines the effect of recombinant murine (rm)IL-10 on antigen-induced cellular recruitment into the airways of sensitized Balb/c mice. The intranasal instillation of 10 pug ovalbumin induced an early (6-24 h) increase in the number of neutrophils, and a late rise (24-96 h) in that of eosinophils in the bronchoalveolar lavage (BAL) fluid and bronchial tissue. A single intranasal instillation of 0.01-0

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Section: Introductionmentioning

confidence: 99%

Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice.

Zuany-Amorim¹,

Hailé²,

Leduc³

et al. 1995

J. Clin. Invest.

250

166

View full text Add to dashboard Cite

show abstract

“…A combination of the variations in the intensity of the inflammatory response according to the immune status of the animal (within the strain) and to strain itself, has also been shown. Thus, more leucotriene C4 is released from isolated mice antigen‐challenged lungs from Swiss than from BALB/c mice [24]. For a similar primary immunization, antigen‐boosted mice respond differently as compared to unboosted and to the lethal and cell‐recruiting effects of PAF [25].…”

Section: The Murine Modelmentioning

confidence: 99%

What can we learn from murine models of asthma?

Vargaftig

1999

Clin Experimental Allergy

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Recent evidence suggests that the development of chronic allergic respiratory disease is a biphasic process. Phase 1 commonly occurs during early childhood and in many instances appears to be initiated in utero. This involves initial priming of the Th-cell system against ubiquitous environmental allergens, and subsequent reshaping of these responses during infancy into Th1- or Th2-polarized immunological memory. The second phase of the process comprises the repeated expression of Th2-polarized allergen-specific immunity at the level of the airway mucosa, producing cumulative damage to local tissue resulting ultimately in phenotypic changes including development of airways hyperreactivity. It is also clear that this second phase occurs in only a relatively small subset of subjects who develop long-term Th2-polarized allergen-specific immunity, given that the majority of skin prick test positive subjects do not develop chronic airways disease. This suggests that an additional set of control mechanisms, which regulate the intensity/duration of local Th-cell responses within airway mucosal tissues, may play an important role in the ultimate expression of chronic immunoinflammatory disease in the airways in 'at risk' atopic subjects.

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Endotoxin-Induced Airway Inflammation and Asthma Models

Helyes

Hajna

2012

Methods in Pharmacology and Toxicology

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Strain‐dependency of leukotriene C₄ generation from isolated lungs of immunized mice

Cited by 9 publications

References 35 publications

Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice.

Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice.

What can we learn from murine models of asthma?

Endotoxin-Induced Airway Inflammation and Asthma Models

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Strain‐dependency of leukotriene C4 generation from isolated lungs of immunized mice

Cited by 9 publications

References 35 publications

Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice.

Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice.

What can we learn from murine models of asthma?

Endotoxin-Induced Airway Inflammation and Asthma Models

Contact Info

Product

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Strain‐dependency of leukotriene C₄ generation from isolated lungs of immunized mice