Stoss therapy using fortified biscuit for vitamin D-deficient children: a novel treatment

Abstract

Stoss therapy using fortified biscuit may be an effective way to improve compliance in children who cannot take capsules without adverse effects and may also be recommended for prevention purposes.

The Prevalence of Vitamin D Deficiency Among Children of 1 - 6 Years Old, Tehran, Iran

“…Screening healthy children for estimating the amount of required vitamin D through medication in addition to sufficient consumption of the nutrients. Finally, countrywide planning for dairy and juice enrichment, and consuming biscuits containing 50000 IU cholecalciferol could also have significant impacts on increasing vitamin D level especially in children (12,(36)(37)(38)(39)(40)(41). A study conducted by Mostafai et al (42) revealed that daily consumption of yogurt fortified with 1000 IU vitamin D for three months could significantly increase serum level of 25(OH) vitamin D by 12.6 ng/dL.…”

Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years

“…The main search resulted in 2063 studies potentially relevant for inclusion ( Figure 1 ); of these, 32 studies 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 (8400 unique participants) met our criteria and were included in this systematic review ( Table 1 ). A subgroup of 21 studies 8 , 9 , 10 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 (7358 unique participants) were eligible for meta-analysis because they included a control group receiving either low-dose vitamin D supplementation (≤400 IU/d) or placebo.…”

“…Daily oral high-dose vitamin D intervention ranged from 1200 to 10 000 IU/d, whereas bolus doses ranged from 30 000 IU/week to 600 000 IU as a single dose. Twenty-five of the 32 RCTs 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 26 , 28 , 32 , 33 , 34 , 35 , 36 , 37 had 2 intervention groups, whereas the remaining 7 studies 25 , 27 , 29 , 30 , 31 , 38 , 39 compared more than 2 groups. Only 1 study 11 used 6 years as the upper age limit in their eligibility criteria.…”

“…Twenty-five of the 32 RCTs 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 26 , 28 , 32 , 33 , 34 , 35 , 36 , 37 had 2 intervention groups, whereas the remaining 7 studies 25 , 27 , 29 , 30 , 31 , 38 , 39 compared more than 2 groups. Only 1 study 11 used 6 years as the upper age limit in their eligibility criteria. Fifteen studies 16 , 20 , 21 , 23 , 25 , 26 , 28 , 30 , 31 , 32 , 34 , 35 , 36 , 37 , 39 included infants (aged 0-12 months) as their only eligible age group, when they were included.…”

“…Fifteen studies 16 , 20 , 21 , 23 , 25 , 26 , 28 , 30 , 31 , 32 , 34 , 35 , 36 , 37 , 39 included infants (aged 0-12 months) as their only eligible age group, when they were included. In 9 studies, 8 , 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 at least 1 intervention group received a bolus dose of greater than 100 000 IU. Intervention doses of less than 2000 IU/d as highest vitamin D supplementation given were only seen among infants, which corresponds to a high-dose intervention in this age group.…”