In the conditions of transformation of geopolitical environment and escalating magnitude of natural and man-made disasters, the international humanitarian cooperation becomes one of the priorities on the agenda of all global actors. This substantiated by the fact that the increasing frequency of natural disasters requires the development of new approaches and programs for addressing the humanitarian issues. The goal of this article lies is the analysis of vectors and peculiarities if cooperation between the Russian Federation and the United Nations, as well as systematicity of their interaction in terms of humanitarian aid and disaster risk reduction. It is established that one of the urgent problems for the Russian Federation in the context of disaster risk reduction is wildfire prevention. The problem attracts as a global challenge has drawn particular attention of the UN.. Special emphasis is placed on the Sendai Framework on Disaster Risk Reduction, which for the Russian Federation and majority of countries of the world, serves as the methodological guide in the questions of participation and interaction with international partners towards overcoming humanitarian disasters and reducing the risks of anthropogenic hazards. Special attention is given to examination of the vectors and measures of support of the Russian Federation to the countries suffered from disasters. The conclusion is made that within the framework of interaction with the United Nations in terms of disaster risk reduction, the Russian Federation fully conforms to all strategic priorities and key provisions of the Sendai Framework on Disaster Risk Reduction. The acquired results are valuable for the improvement and development of the principles of international humanitarian cooperation between the countries in the context of formation of the new paradigm of civilizational development.