Storage and Access Procedures in Schizophrenia: Evidence for a Two Phase Model of Lexical Impairment

Leeson, Verity C.; McKenna, Peter J.; Laws, Keith R.

doi:10.1080/13803390490918507

Cited by 7 publications

(6 citation statements)

References 12 publications

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“…This robust finding supports the notion that lexical semantics is a generalized deficit in schizophrenia (Leeson et al, 2006) and that both action and object name retrieval can be similarly impaired (Woods et al, 2007). Furthermore, the result is in line with findings from studies that have examined visual confrontation naming abilities of schizophrenic individuals compared to controls on object picture naming tasks (Barr et al, 1989;Gabrovska et al, 2003;Laws et al, 2000;Leeson et al, 2006;Leeson et al, 2005) including the Boston Naming Test (Barr et al, 1989;Berenbaum et al, 2008;Vogel et al, 2009). When action and object naming accuracy performances were compared within the schizophrenic group, participants with SCZ showed a grammatical class effect, with action names significantly more difficult to retrieve than object names.…”

Section: Discussionsupporting

confidence: 88%

“…In contrast, nonsemantic or otherwise lexical access impairments in SCZ can include difficulties accessing the target response from among several competing sources of information or problems with strategic search and retrieval (Elvevag, Weinstock, Akil, Kleinman, & Goldberg, 2001). Further, nonlinguistic processes may be impaired in SCZ such as working memory and attention (Braff, 1993;Gold, Carpenter, Randolph, Goldberg, & Weinberger, 1997 Word retrieval breakdown in schizophrenia has been assessed using a variety of tasks including tests of semantic association (Bozikas et al, 2005) and word generation, including category-based (Bokat & Goldberg, 2003;Kubota et al, 2005), letter-based (Berenbaum et al, 2008;Kubota et al, 2005;Woods, Weinborn, Posada, & O'Grady, 2007) verb (action;Marvel, Schwartz, & Isaacs, 2004;Woods et al, 2007), noun (animal;Berenbaum et al, 2008;Woods et al, 2007) fluency tasks and object picture naming tasks (Barr, Bilder, Goldberg, Kaplan, & Mukherjee, 1989;Berenbaum et al, 2008;Laws et al, 2000;Leeson et al, 2006;Leeson, McKenna, & Laws, 2005;Vogel et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Action and object naming in schizophrenia

Kambanaros

Messinis

Georgiou

et al. 2010

Journal of Clinical and Experimental Neuropsychology

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Patients with schizophrenia demonstrate impaired action verbal fluency, but no study has examined verb-noun differences using picture naming. The present study compared object and action naming in 20 adult patients diagnosed with schizophrenia (DSM-IV-TR, Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition, Text Revision; American Psychiatric Association, 2000) criteria, and 20 demographically matched healthy controls, using pictures. Overall, schizophrenic patients showed poorer naming than controls on all measures of object and action lexical semantic access and retrieval despite normal comprehension for action and object names. Results further indicated that action names were significantly more difficult to retrieve than object names in schizophrenic patients. The absence of dissociation in comprehension of action and object names but semantic errors in naming both classes suggests intact conceptual-semantic stores among middle-aged community-dwelling outpatients with schizophrenia but difficulties mapping semantics onto the lexicon. Action-naming impairments can arise from both semantic and postsemantic origins in schizophrenia. These results have implications for the neurobiology of language given the association between both schizophrenia and verb processing and frontal damage. Moreover, the issue being addressed is important for a cognitive characterization of schizophrenia and for an understanding of the representations of action and object names in the brain.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Action and object naming in schizophrenia

Kambanaros

Messinis

Georgiou

et al. 2010

Journal of Clinical and Experimental Neuropsychology

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“…Some researchers have proposed that semantic processing abnormalities in schizophrenia could be caused by abnormal organization of concepts within the semantic network (Aloia et al, 1996;Leeson et al, 2005;Rossell and David, 2006). This disorganized storage could exist instead of, or along with, deficient access to semantic memory.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological insights into conceptual disorganization in schizophrenia

Kiang

Kutas

Light

et al. 2007

Schizophrenia Research

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Disorganized speech, or thought disorder, in schizophrenia may reflect abnormal processing of meaningful concepts. To examine whether schizophrenia involves abnormalities in how a meaningful context influences processing of concepts strongly, weakly, or not related to it, we used the N400, an event-related brain potential (ERP) index of semantic relatedness. ERPs were recorded from schizophrenia patients (n=18) and normal controls (n=18) while they viewed category definitions (e.g., a type of fruit), each followed by a target word that was either a hightypicality category exemplar (apple), low-typicality exemplar (cherry), or non-exemplar (clamp). Participants' task was to indicate via button-press whether or not the target belonged to the category. In both patients and controls, N400 amplitude was largest (most negative) for nonexemplars, intermediate for low-typicality exemplars, and smallest (least negative) for hightypicality exemplars. Compared to controls, patients showed a trend toward reduced N400 amplitude differences between non-exemplars and low-typicality exemplars. Most importantly, within patients, reduced N400 amplitude differences between high-and low-typicality exemplars were correlated with psychotic symptoms. In schizophrenia patients, an N400 index of semantic processing was associated with psychotic symptoms. Psychosis may be associated with greater similarity in how concepts strongly and weakly meaningfully related to their context are processed.

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“…For instance, in terms of semantic dysfunction, Spitzer (1997) constructed a theory wherein TD was proposed to stem from difficulties in the automatic access of lexical-semantic information. Yet, there has been evidence to suggest that degraded semantic storage may also play a role in TD (Leeson et al, 2005a;Rossell and David, 2006). Another proposal was that there is disorganisation within the semantic system, which may better account for residual deficits after the remission of TD (Leeson et al, 2005b).…”

Section: Introductionmentioning

confidence: 99%