Stop, You're Making Me Blush

Oller, Kellee L.; Cao, Kimberly; Parkerson, Jim; Lezama, Jose

doi:10.1016/j.amjmed.2010.09.027

Cited by 9 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first description of this strange autonomic vascular phenomenon, which occurs in the neonatal period and is characterized by a sudden, brief change in skin color, with a sharp and straight line dividing half of the body as if it had been "drawn with a pencil and ruler" that ran precisely within the midline of the head and trunk, with half of the body presenting erythema and the other half pallor, was made in 1952 by Neligan and Strange (1,2) who named it a "Harlequin" color change. This behavior has been reported in newborns (3,4,13,(5)(6)(7)(8)(9)(10)(11)(12), infants (13)(14)(15)(16)(17)(18), children (19)(20)(21)(22), and adult patients (2,23,(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)24,42,43,(25)(26)(27)(28)(29)(30)(31) since that time.…”

Section: Introductionmentioning

confidence: 54%

Harlequin Color Change: a brief literature review

Pinel-Guzmán

Fernández

Dubón³

2021

Rev Cienc Biomed

View full text Add to dashboard Cite

Introducción: en 1952, Neligan y Strange describieron por primera vez un fenómeno raro, que se produce en el periodo neonatal y se caracteriza por un cambio repentino del color de la piel, con una línea recta que divide la mitad del cuerpo como si hubiera sido "dibujada con un lápiz y una regla" que discurre por la línea media, presentando la mitad del cuerpo eritematoso y la otra pálida. Objetivo: presentar literatura relacionada con el fenómeno del cambio de color arlequín y sus diferentes presentaciones clínicas. Métodos: se llevó a cabo una revisión no sistemática de la literatura disponible utilizando palabras claves como “Harlequin Color Change”, “Harlequin Newborn”, “Harlequin Color Change NOT Syndrome NOT ichthyosis” además de sinónimos, que se combinaron con los conectores “AND” y “OR”, tanto en inglés como en español, en las bases de datos PubMed, ScienceDirect y Google Academics. Resultados: el cambio de color arlequín se caracteriza por un aspecto de la piel dividida en dos zonas de color distinto. Se desconoce su etiología, pero se cree que está causado por inmadurez de la regulación hipotalámica del tono vascular periférico. Afecta aproximadamente 10% de los neonatos sanos. Conclusiones: el cambio de color arlequín es una condición benigna, idiopática y autolimitada que no necesita tratamiento. El médico debe reconocer este fenómeno, que presenta una variedad de patrones de cambio de color. Es esencial informar a los padres de esta afección cutánea benigna y transitoria para evitar pruebas y tratamientos innecesarios. No debe confundirse con la ictiosis arlequín.

show abstract

Section: Introductionmentioning

confidence: 54%

Harlequin Color Change: a brief literature review

Pinel-Guzmán

Fernández

Dubón³

2021

Rev Cienc Biomed

View full text Add to dashboard Cite

show abstract

“…Since then, HCC has been described in a fairly broad number of reports involving neonates, 2 3 4 5 6 7 8 9 10 11 12 13 14 15 infants, 16 17 18 19 20 children, 21 22 23 24 and adult patients, 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 either as an isolated finding or as secondary to a specific condition (e.g., exercise, iatrogenic damage, and associated diseases).…”

mentioning

confidence: 99%

Harlequin Color Change: Neonatal Case Series and Brief Literature Review

Valerio

Barlotta

Lorenzon

et al. 2015

AJP Rep

View full text Add to dashboard Cite

First clinical report of Harlequin color change (HCC) phenomenon came in 1952 from Neligan and Strang. Since then, HCC has been described in a fairly broad number of clinical reports involving neonates, infants, children, and adult patients. We here present a small case series of HCC occurring in neonates, pointing out three of the different possible presentations (hemifacial, patchy scattered across the whole body, and hemiscrotal) of this phenomenon. A brief discussion and literature review encompassing epidemiology, clinical features, physiopathology, associated conditions, and differential diagnoses of HCC is then presented. In most cases, HCC represents a benign, idiopathic, and rapidly autoresolutive phenomenon, with no need for treatment. Some drugs (especially anesthetics and prostaglandin E) are thought to enhance HCC expression through their influence on the capillary tone in the peripheral vascular bed; this effect is anyway promptly reversible with drug withdrawal. Only in rare circumstances, HCC may act as a clue for serious central nervous system disorders (e.g., meningitis; hypothalamic, brain stem, or sympathetic nervous system lesions); anyway, in these rare occurrences HCC always represents an epiphenomenon of the disease, never acting as the sole sign of the underlying disorder.

show abstract