“…The overall aim, and the main contribution, is to demonstrate how a set of general methods may be combined into a complete methodology in order to solve a real industrial problem, in this case, the challenging problem of automotive engine FDI (Nyberg and Stutte, 2004). In this sense, this work serves as an illustration of the state-of-practice in model-based FDI, and in particular sequential residual generation, e.g., Staroswiecki and Declerck (1989); Cassar and Staroswiecki (1997); Staroswiecki (2002); Pulido and Alonso-González (2004); Ploix et al (2005); Travé-Massuyès et al (2006); Blanke et al (2006) ;Svärd 3 and Nyberg (2010), and statistical residual evaluation, e.g., Willsky and Jones (1976); Gertler (1998); Basseville and Nikiforov (1993); Peng et al (1997); AlSalami et al (2006); ; Wei et al (2011);Svärd et al (2011b); Caponetti et al (2011). Moreover, as a secondary contribution, the usefulness and properties of the specific methods described in Svärd and Nyberg (2010); Svärd et al (2011a,b); Svärd (2012) are illustrated and discussed.…”