Stink bean (<i>Parkia speciosa</i>) empty pod: a potent natural antidiabetic agent for the prevention of pancreatic and hepatorenal dysfunction in high fat diet/streptozotocin-induced type 2 diabetes in rats

Gao, Lei; Zhang, Wenzhi; Yang, Leiyan; Fan, Hong; Olatunji, Opeyemi Joshua

doi:10.1080/13813455.2021.1876733

Cited by 16 publications

(23 citation statements)

References 40 publications

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“…As such, maintaining normal glycaemic control is paramount in the treatment of diabetes so as to prevent any diabetic associated complication including DE. The results from our study indicated that high fructose/STZ induced diabetes was associated with significantly high levels of FBG and reduced body weight gain which was consistent with results from other previous studies ( Makinde et al, 2020 ; Gao et al, 2021 ).…”

Section: Discussionsupporting

confidence: 93%

“…Type 2 diabetes mellitus (T2DM) is a lifelong complex metabolic disease that affects several millions of individuals globally. T2DM is characterized by unrelenting rise in blood glucose levels (hyperglycemia) resulting from several factors including insulin resistance, unhealthy lifestyle and obesity ( Baglietto-Vargas et al, 2016 ; Zeliha and Canan, 2018 ; Gao et al, 2021 ). The yearly increase in the number of T2DM patients as well as the mortality accrued to the disease is alarming, thus constituting a major global public health issue.…”

Section: Introductionmentioning

confidence: 99%

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Securidaca inappendiculata Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways

2021

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Diabetic encephalopathy is one of the serious emerging complication of diabetes. Securidaca inappendiculata is an important medicinal plant with excellent antioxidant and anti-inflammatory properties. This study investigated the neuroprotective effects of S. inappendiculata polyphenol rich extract (SiPE) against diabetic encephalopathy in rats and elucidated the potential mechanisms of action. Type 2 diabetes mellitus (T2DM) was induced using high fructose solution/intraperitoneal injection of streptozotocin and the diabetic rats were treated with SiPE (50, 100 and 200 mg/kg) for 8 weeks. Learning and memory functions were assessed using the Morris water and Y maze tests, depressive behaviour was evaluated using forced swimming and open field tests, while neuropathic pain assessment was assessed using hot plate, tail immersion and formalin tests. After the experiments, acetylcholinesterase (AChE), oxidative stress biomarkers and proinflammatory cytokines, caspase-3 and nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) were determined by ELISA kits. In addition, the expression levels of p38, phospho-p38 (p-p38), nuclear factor erythroid 2–related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were determined by western blot analyses. The results indicated that SiPE administration significantly lowered blood glucose level, attenuated body weight loss, thermal/chemical hyperalgesia, improved behavioural deficit in the Morris water maze, Y maze test and reduced depressive-like behaviours. Furthermore, SiPE reduced AChE, caspase-3, NF-κB, malonaldehyde malondialdehyde levels and simultaneously increased antioxidant enzymes activity in the brain tissues of diabetic rats. SiPE administration also significantly suppressed p38 MAPK pathway and upregulated the Nrf2 pathway. The findings suggested that SiPE exerted antidiabetic encephalopathy effects via modulation of oxidative stress and inflammation.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Securidaca inappendiculata Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways

2021

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“…In that study, administration of P. speciosa extract at the dose of 100 mg/kg increased SOD (16.56 ± 2.03 vs. 9.19 ± 1.40 U/mg protein), glutathione peroxidase (GSH-Px; 106.76 ± 2.20 vs. 78.29 ± 14.48 U/mg protein), and catalase (CAT; 52.98 ± 4.95 vs. 40.59 ± 6.08 U/mg protein) and reduced MDA levels (20.37 ± 3.25 vs. 36.42 ± 8.01 nmol/mg protein) in liver tissues of treated diabetic rats compared to diabetic controls. In the same study [ 57 ], treatment with a higher dose of extract (400 mg/kg) was associated with increased SOD (18.10 ± 1.52 vs. 9.19 ± 1.40 U/mg protein) and GSH-Px (206.19 ± 19.29 vs. 78.29 ± 14.48 U/mg protein), CAT (68.20 ± 3.97 vs. 40.59 ± 6.08 U/mg protein) and reduced MDA (17.65 ± 2.38 vs. 36.42 ± 8.01 nmol/mg protein) in the liver tissues of diabetic rats compared to diabetic controls. In addition, the effects of P. speciosa extract on antioxidant enzyme levels were significantly improved in the kidney tissues of treated diabetic rats compared to diabetic controls [ 57 ].…”

Section: Pharmacological Potential Of P Speciosa E...mentioning

confidence: 99%

“…In the same study [ 57 ], treatment with a higher dose of extract (400 mg/kg) was associated with increased SOD (18.10 ± 1.52 vs. 9.19 ± 1.40 U/mg protein) and GSH-Px (206.19 ± 19.29 vs. 78.29 ± 14.48 U/mg protein), CAT (68.20 ± 3.97 vs. 40.59 ± 6.08 U/mg protein) and reduced MDA (17.65 ± 2.38 vs. 36.42 ± 8.01 nmol/mg protein) in the liver tissues of diabetic rats compared to diabetic controls. In addition, the effects of P. speciosa extract on antioxidant enzyme levels were significantly improved in the kidney tissues of treated diabetic rats compared to diabetic controls [ 57 ].…”

Section: Pharmacological Potential Of P Speciosa E...mentioning

confidence: 99%

Phytochemical Contents and Pharmacological Potential of Parkia speciosa Hassk. for Diabetic Vasculopathy: A Review

et al. 2022

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Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and is considered a major health problem in the world. It is associated with endothelial dysfunction which causes progressive vascular damage. DM is a known risk factor for atherosclerosis and cardiovascular complications such as peripheral artery disease, coronary artery disease, and stroke. Medicinal plants may act as an alternative resource or adjunctive treatment option in the treatment of diabetes and its cardiovascular complications. Parkia speciosa (Fabaceae) is a plant found abundantly in the Southeast Asian region. Its seeds, with or without pods, and roots have long been used as a traditional medicine in this region to treat hypertension and diabetes. Studies have shown its numerous beneficial pharmacological properties. Extracts of P. speciosa, particularly from its seeds and empty pods, show the presence of polyphenols. They also exhibit potent antioxidant, hypoglycemic, anti-inflammatory, and antihypertensive properties. Its hypoglycemic properties are reported to be associated with the presence of β-sitosterol, stigmasterol, and stigmat-4-en-3-one. The current review aimed to provide an overview of the current status of P. speciosa, its pharmacological potential, and its phytochemical content in attenuating diabetic vasculopathy. Glycemic status, oxidative stress, inflammation, and hyperlipidemia are known to play pivotal roles in the initiation and severity of diabetic cardiovascular diseases; thus, targeting these factors might be beneficial for preventing and/or treating diabetic vasculopathy.

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“…A number of anti‐diabetic drugs are used to improve insulin resistance by activating the PPAR‐γ receptor that mediates an increase in adiponectin transcription and expression (Shao et al., 2016). Although many drugs are used for the treatment of diabetes, their use is limited due to increased likelihood of side effects (Gao et al, 2021). Hence, there is an unmet need of the society to search for a better option having minimal adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Effect of thymoquinone on high fat diet and STZ‐induced experimental type 2 diabetes: A mechanistic insight by in vivo and in silico studies

et al. 2021

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The aim was to investigate whether thymoquinone (TQ) attenuates hyperglycemia‐induced insulin resistance in experimental type 2 diabetes. Type 2 diabetes mellitus (T2DM) was induced by injection of streptozotocin (STZ, 40 mg/kg) in high fat diet (HFD) rats. The levels of glucose, insulin, area under curve (AUC) of glucose, lipid profile parameters, homeostasis model assessment of insulin resistance (HOMA‐IR), peroxisome proliferator‐activated receptor‐γ (PPARγ), and dipeptidyl peptidase peptidase‐IV (DPP‐IV) were evaluated in HFD + STZ‐induced type 2 diabetic rats. TQ treatment significantly reduced elevated levels of glucose, AUC of glucose, insulin, and DPP‐IV in diabetic‐treated groups. In addition, TQ treatment significantly reduced high levels of triglycerides (TG) and cholesterols (total, low‐density and very low‐density lipoprotein) accompanied by significant augmentation in high‐density lipoprotein (HDL) levels in diabetic‐treated groups. However, TQ treatment significantly improved insulin sensitivity in diabetic‐treated groups, which was confirmed by increased level of PPARγ and decreased level of HOMA‐IR. Molecular docking of TQ exhibited substantial binding affinity with PPARγ and DPP‐IV target proteins, which is supported by in vivo results. These results demonstrate that TQ attenuates hyperglycemia‐induced insulin resistance by counteracting hyperinsulinemia, improving lipid profile, insulin sensitivity, and inhibiting DPP‐IV. Practical applications T2DM results in relentless hyperglycemia which eventually progress to a state of insulin resistance. TQ is an active principle compound found in Nigella sative seed, having myriad of traditional medicinal values. Administration of TQ significantly prevented hyperglycemia, hyperinsulinemia, hyperlipidemia, insulin resistance, and inhibited DPP‐IV in experimental type 2 diabetes. The in vivo results are also supported by molecular docking study of PPARγ and DPP‐IV target proteins. Thus, we hypothesize that TQ can be used as an alternative natural drug in the management of hyperglycemia‐induced insulin resistance in T2DM.

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Stink bean (Parkia speciosa) empty pod: a potent natural antidiabetic agent for the prevention of pancreatic and hepatorenal dysfunction in high fat diet/streptozotocin-induced type 2 diabetes in rats

Cited by 16 publications

References 40 publications

Securidaca inappendiculata Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways

Securidaca inappendiculata Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways

Phytochemical Contents and Pharmacological Potential of Parkia speciosa Hassk. for Diabetic Vasculopathy: A Review

Effect of thymoquinone on high fat diet and STZ‐induced experimental type 2 diabetes: A mechanistic insight by in vivo and in silico studies

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