Stimulus-responsive polymeric nanoparticles for biomedical applications

Li, YongYong; Dong, Haiqing; Wang, Kang; Shi, Donglu; Zhang, Xian‐Zheng; Zhuo, Ren‐Xi

doi:10.1007/s11426-010-0101-4

Cited by 57 publications

(27 citation statements)

References 105 publications

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“…Drug delivery systems (DDs) based on polymeric micelles, vesicles, prodrugs and organic-inorganic nanoparticles with selective drug release behavior in response to a specific signal (from tumor milieu or external stimulus) have been developed and comprehensively summarized in other reviews [31][32][33][34][35][36]. For example: those physical signals can be temperature, pH, light, magnetic field, ultrasound and so forth [33,37]. Some of the stimulus sensitive DDSs have been clinically evaluated (ThermoDoxs ® ) or even already approved for clinical use (NanoTherm ® ) [31].…”

Section: Gsh-sensitive Disulfide For Cleavable Pegylationmentioning

confidence: 99%

Disulfide-Bridged Cleavable PEGylation in Polymeric Nanomedicine for Controlled Therapeutic Delivery

Dong

Tang

et al. 2015

Nanomedicine (Lond.)

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PEGylation in polymeric nanomedicine has gained substantial predominance in biomedical applications due to its resistance to protein absorption, which is critically important for a therapeutic delivery system in blood circulation. The shielding layer of PEGylation, however, creates significant steric hindrance that negatively impacts cellular uptake and intracellular distribution at the target site. This unexpected effect compromises the biological efficacy of the encapsulated payload. To address this issue, one of the key strategies is to tether the disulfide bond to PEG for constructing a disulfide-bridged cleavable PEGylation. The reversible disulfide bond can be cleaved to enable selective PEG detachment. This article provides an overview on the strategy, method and progress of PEGylation nanosystem with the cleavable disulfide bond.

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Section: Gsh-sensitive Disulfide For Cleavable Pegylationmentioning

confidence: 99%

Disulfide-Bridged Cleavable PEGylation in Polymeric Nanomedicine for Controlled Therapeutic Delivery

Dong

Tang

et al. 2015

Nanomedicine (Lond.)

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“…[ 54 , 55 ] This reversible behavior is controlled by chemical synthesis with the incorporation of co-polymers to enable responses to a range of chemical cues like pH. [56][57][58][59][60][61][62][63][64][65][66][67][68][69] These polymers were aptly dubbed "smart polymers" due to their ability to respond to environmental cues. Since Tanaka's initial work, environmentally-sensitive polymers have been demonstrated to actuate in response to changes in pH, temperature, ionic strength, UV/visible light, photosynthetic stimulation and magnetic/electrical fi elds.…”

Section: Stimuli-responsive Polymersmentioning

confidence: 99%

Microchemomechanical Systems

Randhawa¹,

Laflin²,

Seelam³

et al. 2011

Adv Funct Materials

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The development of microchemomechanical systems (MCMS) as an analogy to microelectromechanical systems (MEMS) is reviewed, with the distinction that the mechanical actuation of microscale structures is effected by chemical cues as opposed to electricity. The intellectual motivation to pursue MCMS, or the creation of integrated chemical-stimuli-responsive devices, is that such structures are widely observed in nature. From a practical standpoint, since chemicals can readily diffuse and produce changes over large distances, this approach is especially attractive in enabling wireless and autonomous devices at small size scales.

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“…In a recent review from Zhuo's group [20], they reported that stimulus-responsive polymeric nanoparticles, which can change their structures, shapes, and properties after being exposed to external signals (including pH, temperature, magnetic field, photo, etc. ), are considered as the most promising materials for biomedical applications including drug delivery, gene delivery and imaging.…”

Section: Polypeptide Based Vectorsmentioning

confidence: 99%

Current progress of polymeric gene vectors

Zhang

Sun

Zhuo

et al. 2011

Sci. China Life Sci.

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After over 40 years of progress, gene therapy provides great opportunities for treating diseases from various genetic disorders, infections and cancers. The success of gene therapy largely depends on the availability of suitable gene vectors. As an attractive alternative to virus-based gene therapy, non-viral gene delivery system has been developed and investigated due to their merits including low immunogenecity, convenient operability, and large-scale manufacturability [1]. Because polycations can condense with DNA as a result of electrostatic interactions, form nanosize polyplexes, and protect DNA from degradation by DNase, cationic polymer becomes a major type of non-viral gene delivery vectors ( Figure 1) [2]. A wide range of polymeric vectors have been developed and investigated in the past decade, such as polyethylenimine (PEI)-based vectors, poly(L-lysine) (PLL)-based vectors, dendrimer-based vectors, polypeptide-based vectors, and chitosan-based vectors [3]. However, unlike viral vectors that have the ability to infect host cells and overcome cellular barriers through the course of evolution, nonviral gene vectors exhibit significantly reduced transfection efficiency as they are obstructed by various extra-and intracellular barriers, including serum proteins in blood stream, cell membrane, endosomal compartment and nuclear membrane [4].As a result, numerous studies have focused on designing polymer carriers that have smart molecular structure, present good biocompatibility, avoid both in vitro and in vivo barriers, and achieve successful delivery of genetic material [1]. To circumvent different systemic and cellular obstacles Figure 1 Three main strategies employed to package DNA [4].during gene delivery, proper functional groups were conjugated to polymeric vectors. The current modification of polymeric vectors has shown great improvements in enhancing intracellular gene transfer efficiency and attaining tumor targeted gene delivery [4]. For example, receptormediated cell uptake can quickly deliver ligand-targeted polyplexes into endosomes, membrane active compounds (lipids and peptides) can enhance the release of endocytosed materials. Moreover, nuclear localization signal peptides can enhance both the nuclear transport and expression of DNA. Here, current research progress regarding polymeric gene vectors that mainly published in Chinese magazines from 2010 was reviewed, and future trends for the polymer-based gene delivery systems would also be delineated.

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Stimulus-responsive polymeric nanoparticles for biomedical applications

Cited by 57 publications

References 105 publications

Disulfide-Bridged Cleavable PEGylation in Polymeric Nanomedicine for Controlled Therapeutic Delivery

Disulfide-Bridged Cleavable PEGylation in Polymeric Nanomedicine for Controlled Therapeutic Delivery

Microchemomechanical Systems

Current progress of polymeric gene vectors

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