Disulfide-Bridged Cleavable PEGylation in Polymeric Nanomedicine for Controlled Therapeutic Delivery

Dong, Haiqing; Tang, Min; Li, Yan; Li, Yongyong; Qian, Dong; Shi, Donglu

doi:10.2217/nnm.15.38

Cited by 39 publications

(15 citation statements)

References 98 publications

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“…Some key examples of nanoparticulate polymer systems proposed for the delivery of polyphenols are summarized in Table 1 . The main attention is devoted to the materials coupling biocompatibility and biodegradability such as naturally occurring chitosan (Jayakumar et al, 2010 ) and synthetic PLGA (Danhier et al, 2012 ), while PEG derivatives are widely explored for the surface functionalization preventing macrophage uptake of nanoparticles (Dong et al, 2015 ).…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Polyphenols delivery by polymeric materials: challenges in cancer treatment

et al. 2017

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Nanotechnology can offer different solutions for enhancing the therapeutic efficiency of polyphenols, a class of natural products widely explored for a potential applicability for the treatment of different diseases including cancer. While possessing interesting anticancer properties, polyphenols suffer from low stability and unfavorable pharmacokinetics, and thus suitable carriers are required when planning a therapeutic protocol. In the present review, an overview of the different strategies based on polymeric materials is presented, with the aim to highlight the strengths and the weaknesses of each approach and offer a platform of ideas for researchers working in the field.

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Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Polyphenols delivery by polymeric materials: challenges in cancer treatment

et al. 2017

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“…1 A , When the MS-DDS leaks into the tumor site, the linker between PEG and the particle core is cleaved by the stimuli in the tumor microenvironment and the PEG layer is detached, thus exposing the original nanoparticle with an enhanced surface-cell interaction and increasing the antitumor effect. Hypoxic-degradable nitroimidazole 26 , redox-degradable disulfide bond 43 , acid-degradable amide bond 44 , and 2-propionic-3-methylmaleic anhydride (CDM) 45 have been applied in the PEG detachable Ms-DDS for improved chemotherapeutics and siRNA delivery. In the acid-degradable amide bond example, PEG- Dlink m -PLGA was developed by introducing a pH-sensitive link ( Dlink m ), which resulted in a significant increase in the cellular uptake of the pH sensitive dPEG NP PLGA when pretreated at pH 6.5 compared with pretreatment at pH 7.4.…”

Section: Design Responsive Modes and Functions Of Ms-ddsmentioning

confidence: 99%

Current Multistage Drug Delivery Systems Based on the Tumor Microenvironment

et al. 2017

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The development of traditional tumor-targeted drug delivery systems based on EPR effect and receptor-mediated endocytosis is very challenging probably because of the biological complexity of tumors as well as the limitations in the design of the functional nano-sized delivery systems. Recently, multistage drug delivery systems (Ms-DDS) triggered by various specific tumor microenvironment stimuli have emerged for tumor therapy and imaging. In response to the differences in the physiological blood circulation, tumor microenvironment, and intracellular environment, Ms-DDS can change their physicochemical properties (such as size, hydrophobicity, or zeta potential) to achieve deeper tumor penetration, enhanced cellular uptake, timely drug release, as well as effective endosomal escape. Based on these mechanisms, Ms-DDS could deliver maximum quantity of drugs to the therapeutic targets including tumor tissues, cells, and subcellular organelles and eventually exhibit the highest therapeutic efficacy. In this review, we expatiate on various responsive modes triggered by the tumor microenvironment stimuli, introduce recent advances in multistage nanoparticle systems, especially the multi-stimuli responsive delivery systems, and discuss their functions, effects, and prospects.

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“…In Vivo and Ex Vivo Gene Therapy for Inherited and Non-Inherited Disorders glycol [7] and cell-specific targeting ligand on the surface of the liposome, have been extensively studied. Development of a promising linker also improves stability, biodegradability, and transfection efficiency and reduces cytotoxicity [8].…”

Section: Liposome-based Approachmentioning

confidence: 99%

Nucleic Acid-Based Therapy: Development of a Nonviral-Based Delivery Approach

Yokoo¹,

Kamimura²,

Kanefuji³

et al. 2019

In Vivo and Ex Vivo Gene Therapy for Inherited and Non-Inherited Disorders

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Gene therapy returns to the center stage of medicine to treat patients with diseases that are unable to be cured with the conventional therapeutic strategies. This development is due to various reasons, including vector development and significant achievement in nextgeneration sequencing. Among the various methodologies of gene therapy, nucleic acidbased therapy has been considered to be promising in various diseases. The development of delivery methods to target cells in vivo, however, remains critical. These include viral vector-based and nonviral vector-based gene delivery methods as well as physical approaches such as hydrodynamic gene delivery (HGD). HGD is a simple and effective in vivo gene transfer method for the functional analysis of therapeutic genes and regulatory elements in small animals. Moreover, this chapter outlines the principle of HGD, gene expression studies in rodents, and recent advances in clinical application of HGD and provides future perspectives in developing a safe and efficient method for nucleic acidbased therapy.

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Disulfide-Bridged Cleavable PEGylation in Polymeric Nanomedicine for Controlled Therapeutic Delivery

Cited by 39 publications

References 98 publications

Polyphenols delivery by polymeric materials: challenges in cancer treatment

Polyphenols delivery by polymeric materials: challenges in cancer treatment

Current Multistage Drug Delivery Systems Based on the Tumor Microenvironment

Nucleic Acid-Based Therapy: Development of a Nonviral-Based Delivery Approach

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