Stimulus-responsive phototherapeutic micellar platform of Rose Bengal B: A new perspective for the treatment of wounds

Campanholi, Katieli da Silva Souza; Júnior, Ranulfo C. da S.; Silva, Isabella Cazelatto da; Santos, Rafaela Said dos; Vecchi, Camila Félix; Bruschi, Marcos Luciano; Pozza, Magali Soares dos Santos; Castro-Hoshino, Lidiane Vizioli de; Baesso, Mauro Luciano; Hioka, Noboru; Caetano, Wilker; Batistela, Vagner Roberto

doi:10.1016/j.jddst.2021.102739

Cited by 7 publications

(3 citation statements)

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“…In addition, they decrease side effects (toxicity) and microbial resistance. In this sense, several carrier systems are generally constituted by colloidal dispersion systems, such as copolymeric micelles [35], liposomal vesicles [36], dendrimers [37], cyclodextrins [38,39], polymer-DNA complexes (polyplexes) [40], nanogels [41], nanotubes [42], nanosuspensions [43], nanocrystals [44], solid lipid nanoparticles [45], metallic or ceramic nanoparticles [46], among other nanoscale materials for medical use are being widely studied [47][48][49]. Figure 4 illustrates the most commonly found nanoparticulate carrier systems in the literature for carrying PS [50].…”

Section: Photosensitizer Formulationmentioning

confidence: 99%

“…Parameters such as bioaccessibility, passive transport, and permeation of the drug into the membrane are of great importance in developing new drugs for PDT applications [11,52]. Micellar and liposomal environments, for example, are reasonable models of cellular environments and provide useful information about PS molecules against organized systems and biomimetics [5,41,52,53].…”

Section: Photosensitizer Formulationmentioning

confidence: 99%

“…Micelles simulate the interface of a biomembrane and provide a biomimetic environment for the study of specific interactions, as well as the penetration and location of PS in the intracellular domain [4,5]. Furthermore, studies have shown that PS incorporation into micellar systems can reduce toxicity, target PS to specific sites and improve permeation and bioavailability in topical applications [11,41]. Given these particularities, the biotransport and delivery of the drug in the target tissue become a particular challenge in PDT [4].…”

Section: Polymeric Nanoparticles: Copolymeric Micellar Systems In Dru...mentioning

confidence: 99%

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Phenazines and Photoactive Formulations: Promising Photodrugs for Photodynamic Therapy

Júnior¹,

Campanholi²,

Morais³

et al. 2023

Dyes and Pigments - Insights and Applications

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Photodynamic Therapy (PDT) is a therapeutic modality that can be applied with many photosensitizing compounds (PS). Photosensitization has shown promising results in damage against abnormal cell growth as cancer and inactivating a broad spectrum of microorganisms with no reported microbial resistance. Photodynamic processes occur by the light action at the appropriate wavelength in the presence of a PS that will be excited by the energy absorbed from the light source, where the interaction with the oxygen present in the cell will generate reactive oxygen species (ROS). The potential of phenazines as a photosensitizer is reviewed in this chapter as a practical guide to the future development of formulations that are effective for cancer treatment and microorganism control. Here we mainly summarize articles about phenazines from 2005 to 2021 when we performed a systematic search in the Science Direct, PubMed, Google Scholar, Web of Science, and Scopus databases. The carrier systems formed by micellar copolymers type Pluronic® have demonstrated effectiveness in incorporating several PS, ensuring its monomeric form for PDT applications. The fundamentals of the photosensitization mechanism are discussed. Studies have shown the beneficial impact of an appropriate incorporation technique to enhance the cellular uptake of phenazines compounds.

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