Stimulus‐Responsive Hydrogel for Ophthalmic Drug Delivery

Lin, Deqing; Lei, Lei; Shi, Shuai; Li, Xingyi

doi:10.1002/mabi.201900001

Cited by 45 publications

(23 citation statements)

References 149 publications

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“…F127 and PNIPAM are regularly used for thermo-responsive polymer. But their applications are limited by fast dissolution in aqueous solution for F127 and low bioactivity for PNIPAM ( Lin et al, 2019 ; Yap and Yang, 2020 ). Therefore, F127 was modified with carboxymethyl hexanoyl chitosan to retard the dissolution of F127 ( Yap and Yang, 2020 ).…”

Section: Classification Of Hydrogelsmentioning

confidence: 99%

Rational Design of Smart Hydrogels for Biomedical Applications

Zhang

Huang

2021

Front. Chem.

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Hydrogels are polymeric three-dimensional network structures with high water content. Due to their superior biocompatibility and low toxicity, hydrogels play a significant role in the biomedical fields. Hydrogels are categorized by the composition from natural polymers to synthetic polymers. To meet the complicated situation in the biomedical applications, suitable host–guest supramolecular interactions are rationally selected. This review will have an introduction of hydrogel classification based on the formulation molecules, and then a discussion over the rational design of the intelligent hydrogel to the environmental stimuli such as temperature, irradiation, pH, and targeted biomolecules. Further, the applications of rationally designed smart hydrogels in the biomedical field will be presented, such as tissue repair, drug delivery, and cancer therapy. Finally, the perspectives and the challenges of smart hydrogels will be outlined.

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Section: Classification Of Hydrogelsmentioning

confidence: 99%

Rational Design of Smart Hydrogels for Biomedical Applications

Zhang

Huang

2021

Front. Chem.

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“…The anterior segment comprises the anterior chamber, which is located between the cornea and the iris, and the posterior chamber, which extends from the iris to the lens. Adapted from Lin et al (2019) [21].…”

Section: Introductionmentioning

confidence: 99%

Biofabrication of Artificial Stem Cell Niches in the Anterior Ocular Segment

et al. 2021

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The anterior segment of the eye is a complex set of structures that collectively act to maintain the integrity of the globe and direct light towards the posteriorly located retina. The eye is exposed to numerous physical and environmental insults such as infection, UV radiation, physical or chemical injuries. Loss of transparency to the cornea or lens (cataract) and dysfunctional regulation of intra ocular pressure (glaucoma) are leading causes of worldwide blindness. Whilst traditional therapeutic approaches can improve vision, their effect often fails to control the multiple pathological events that lead to long-term vision loss. Regenerative medicine approaches in the eye have already had success with ocular stem cell therapy and ex vivo production of cornea and conjunctival tissue for transplant recovering patients’ vision. However, advancements are required to increase the efficacy of these as well as develop other ocular cell therapies. One of the most important challenges that determines the success of regenerative approaches is the preservation of the stem cell properties during expansion culture in vitro. To achieve this, the environment must provide the physical, chemical and biological factors that ensure the maintenance of their undifferentiated state, as well as their proliferative capacity. This is likely to be accomplished by replicating the natural stem cell niche in vitro. Due to the complex nature of the cell microenvironment, the creation of such artificial niches requires the use of bioengineering techniques which can replicate the physico-chemical properties and the dynamic cell–extracellular matrix interactions that maintain the stem cell phenotype. This review discusses the progress made in the replication of stem cell niches from the anterior ocular segment by using bioengineering approaches and their therapeutic implications.

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“…In this context, the development of stimuli-responsive polymers (SRPs), which can respond to slight changes in ocular environments, has proven to be greatly beneficial for triggering the release of ophthalmic drugs in a sustained manner and provides an improved method for treating ocular diseases. In the last three years, there have been a number of review articles highlighting SRPs for various applications such as biosensors and artificial muscles 9 and injectable/stimuli-responsive hydrogel-based DDSs [10][11][12] or emphasizing on the role of degradable polymeric nanoparticles in ocular DDSs. 13 However, a review that presents the design, modification, and construction of SRPs into various forms (not limited to hydrogels) for improving the uses of ophthalmic DDSs and their structural effects on the effectiveness of eye disease treatments has not been reported yet.…”

Section: Introductionmentioning

confidence: 99%