Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment

Nguyen, Duc Khuong; Lai, Jui‐Yang

doi:10.1039/d0py00919a

Cited by 72 publications

(44 citation statements)

References 136 publications

(148 reference statements)

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“…Stimuli-responsive polymers respond sharply to the environment, resulting in an alteration of the polymeric structures and transformation of macroscopic properties such as bond cleavage, degradation, and changes in energy level. These polymers have received considerable attention in the pharmaceutical and biomedical fields due to their unique properties, including a lower or higher critical solution temperature and the ability to return to their initial state after the trigger is removed (reversibility) [ 106 , 107 , 108 , 109 , 110 ]. Thus, based on the available approaches, temperature, pH, ionic, combination and other responsive systems will be discussed in the following sections.…”

Section: Novel Approaches For Vaginal Drug Delivery For Microbial mentioning

confidence: 99%

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

et al. 2020

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An optimal host–microbiota interaction in the human vagina governs the reproductive health status of a woman. The marked depletion in the beneficial Lactobacillus sp. increases the risk of infection with sexually transmitted pathogens, resulting in gynaecological issues. Vaginal infections that are becoming increasingly prevalent, especially among women of reproductive age, require an effective concentration of antimicrobial drugs at the infectious sites for complete disease eradication. Thus, topical treatment is recommended as it allows direct therapeutic action, reduced drug doses and side effects, and self-insertion. However, the alterations in the physiological conditions of the vagina affect the effectiveness of vaginal drug delivery considerably. Conventional vaginal dosage forms are often linked to low retention time in the vagina and discomfort which significantly reduces patient compliance. The lack of optimal prevention and treatment approaches have contributed to the unacceptably high rate of recurrence for vaginal diseases. To combat these limitations, several novel approaches including nano-systems, mucoadhesive polymeric systems, and stimuli-responsive systems have been developed in recent years. This review discusses and summarises the recent research progress of these novel approaches for vaginal drug delivery against various vaginal diseases. An overview of the concept and challenges of vaginal infections, anatomy and physiology of the vagina, and barriers to vaginal drug delivery are also addressed.

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Section: Novel Approaches For Vaginal Drug Delivery For Microbial mentioning

confidence: 99%

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

et al. 2020

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“…The choroid was the only inner eye tissue with a treatment group significantly different than the control, and the difference was much smaller than in the exterior eye tissues, indicating limited penetration into the inner eye. The majority of topically applied substances in solution are subject to clearance by lacrimal fluids on the eye, thereby limiting bioavailability in the inner eye 20 and may benefit from application of the nanoformulation in a thermosensitive gel 3 , 4 , 21 . Paracellular permeation of nanoparticles through the corneal epithelium is extremely challenging due to tight junctions between cells, forcing most nanoparticles to permeate via the transcellular route into the eye 22 .…”

Section: Discussionmentioning

confidence: 99%

“…However, the protective barriers within the eye limit the efficiency and effectiveness of these treatments 1 . Advancements in nanoparticle therapeutics for ocular drug delivery have provided an alternative treatment option, which enhances spatiotemporal control of drug delivery and can exhibit stimuli-responsive behavior such as thermos-responsive gelling or pH-triggered drug release with advanced formulations 2 , 3 . Polymeric nanoparticle drug delivery systems have been tested for the treatment of various eye diseases including cataracts 4 , glaucoma 5 , corneal graft rejection 6 , and autoimmune uveitis 7 .…”

Section: Introductionmentioning

confidence: 99%

Stability and ocular biodistribution of topically administered PLGA nanoparticles

Swetledge

Carter

Stout

et al. 2021

Sci Rep

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Polymeric nanoparticles have been investigated as potential delivery systems for therapeutic compounds to address many ailments including eye disease. The stability and spatiotemporal distribution of polymeric nanoparticles in the eye are important regarding the practical applicability and efficacy of the delivery system in treating eye disease. We selected poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with lutein, a carotenoid antioxidant associated with eye health, as our model ophthalmic nanodelivery system and evaluated its stability when suspended in various conditions involving temperature and light exposure. We also assessed the ocular biodistribution of the fluorescently labeled nanoparticle vehicle when administered topically. Lutein-loaded nanoparticles were stable in suspension when stored at 4 °C with only 26% lutein release and no significant lutein decay or changes in nanoparticle morphology. When stored at 25 °C and 37 °C, these NPs showed signs of bulk degradation, had significant lutein decay compared to 4 °C, and released over 40% lutein after 5 weeks in suspension. Lutein-loaded nanoparticles were also more resistant to photodegradation compared to free lutein when exposed to ultraviolet (UV) light, decaying approximately 5 times slower. When applied topically in vivo, Cy5-labled nanoparticles showed high uptake in exterior eye tissues including the cornea, episcleral tissue, and sclera. The choroid was the only inner eye tissue that was significantly higher than the control group. Decreased fluorescence in all exterior eye tissues and the choroid at 1 h compared to 30 min indicated rapid elimination of nanoparticles from the eye.

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“…As the temperature increased, hydrogen bonds break and the domination of hydrophobic associations occurred, hence resulting in the gel formation [ 11 ]. A sustained drug delivery system can mainly depend upon the use of these types of polymers with the ability to undergo sol-gel transition at physiological conditions, or simply known as the human body temperature [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

et al. 2021

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Hidradenitis suppurativa (HS) has been considered an orphan disease with limited treatments available. The available topical treatment for this condition is clindamycin lotion; however, short retention and frequent application are the main setbacks. Thus, the present study aimed to attain an optimized antibacterial in situ spray formulation for the hidradenitis suppurativa skin condition, which gels once in contact with the skin surface at around 37 °C and possesses bioadhesion as well as sustained-release properties of the incorporated drug. Different concentrations of thermo-reversible gelling polymer, Pluronic F-127, were investigated along with the selected bioadhesive polymers, HPMC and SA. The optimized formulation F3 consisting of 18% Pluronic F-127 with 0.2% HPMC and 0.2% SA was characterized based on various physicochemical properties. The gelation temperature of F3 was found to be 29.0 ± 0.50 °C with a gelation time of 1.35 ± 0.40 min and a pH of 5.8. F3 had the viscosity of 178.50 ± 5.50 cP at 25 °C and 7800 ± 200 cP at 37 °C as the gel set. The optimized formulation was found to be bioadhesive and cytocompatible. Cumulative drug release was 65.05% within the time-frame of 8 h; the release pattern of the drug followed zero-order kinetics with the Higuchi release mechanism. The average zone of inhibition was found to be 43.44 ± 1.34 mm. The properties of F3 formulation reflect to improve residence time at the site of application and can enhance sustained drug release. Therefore, it could be concluded that optimized formulation has better retention and enhanced antimicrobial activity for superior efficacy against HS.

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Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment

Abstract: The development of efficient therapies for ocular diseases remains a significant challenge because of the static and dynamic barriers in the eye. A variety of pharmaceutical strategies have been explored...

Cited by 72 publications

References 136 publications

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

Stability and ocular biodistribution of topically administered PLGA nanoparticles

Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

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