Stimuli-responsive organization of block copolymers on DNA nanotubes

Reversible Loading of Nanoscale Elements on a Multicomponent Supramolecular Polymer System by Using DNA Strand Displacement

“…DNA has been widely exploited as a nanotechnological building block because of its precise dimensions, sequence programmability, and dynamic character . The recent use of DNA on its own or in combination with covalent polymers, amphiphiles, or nanoparticles has resulted in stimuli‐responsive scaffolds sensitive to specific nucleic acid inputs or to (bio)molecules through the introduction of aptamers . It is thus highly appealing to introduce these types of features into supramolecular polymer materials based on amphiphiles to exploit their potential for orthogonal self‐assembly to tune both the properties and function of materials.…”

“…[24][25][26][27][28] The recent use of DNA on its own or in combination with covalent polymers, amphiphiles, or nanoparticles has resulted in stimuli-responsive scaffolds sensitive to specific nucleic acid inputs or to (bio)molecules through the introduction of aptamers. [29][30][31][32][33][34] It is thus highly appealing to introduce these types of features into supramolecular polymer materials based on amphiphiles to exploit their potential for orthogonal self-assembly to tune both the properties and functiono fm aterials. However,o nly af ew groups have examined this powerful combination thus far.…”

Solid‐Phase Incorporation of an ATRP Initiator for Polymer–DNA Biohybrids

“…[1][2][3][4][5][6] Among these, DNA block copolymers (DNABCps) are a novel class of bioconjugates that have a DNA segment covalently attached to an organic polymer segment. [10][11][12][13][14][15][16] These DNABCps have been used in sensitive biological sensors for single-nucleotide polymorphism detection and as scaffolds for organic reactions. Such control has led to DNABCps that form reversible micelles and nanoscale assemblies, including some that are responsive to DNA-based recognition events.…”

Efficient DNA–Polymer Coupling in Organic Solvents: A Survey of Amide Coupling, Thiol-Ene and Tetrazine–Norbornene Chemistries Applied to Conjugation of Poly(N-Isopropylacrylamide)

“…Instead, PAGE control experiments were performed to eliminate the possibility that these bands were caused by other species such as degradation products, dimers, or non-specific association of s0 with poly(NIPAM) (Supplementary Figure S8). A large number of previous reports also assign a broad, slow-moving band to a conjugation product81011121314151617212223242526273031323334.…”

“…further demonstrates the unique properties that DNA-polymer conjugates can possess. They used DNA to control the precise placement of polymer domains within hybrid structures, and demonstrated the ability of polymers conjugated to DNA to form discrete nanocube structures, which predictably changed the polymer’s self-assembly behaviour, as well as introducing a new driving force for the assembly of DNA nanostructures in the form of hydrophobic interactions13141516. Our own group also made the first report of a DNA-polymer conjugate in which the DNA was used to form part of a discrete nanostructure, in this case a DNA tetrahedron17.…”