Stimuli-responsive metal–organic framework hydrogels endow long carbon fiber reinforced polyetheretherketone with enhanced anti-inflammatory and angiogenesis and osteogenesis

Dong, Wei; Zhao, Shanshan; Wang, Yilong; Zhou, Xingyu; Jiang, Junhui; Dang, Junbo; Sun, Da; Dai, Xin; Zhang, Mei; Jiang, Zhenhua

doi:10.1016/j.matdes.2022.111485

Cited by 16 publications

(21 citation statements)

References 62 publications

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“…Besides the early rapid vascularization that guides the migration of osteoblast precursors from the periosteum to the bone marrow, some important substances are also transported through blood vessels, such as oxygen, nutrients, and growth factors related to new bone formation. , Thus, promoting the angiogenesis of endothelial cells is also critical for the osteogenesis of implants. The multifunctional surface modification of CFRPEEK as implants should comprehensively consider the biological processes closely related to osteogenesis, including the immuno-inflammatory response, angiogenesis, and bone regeneration …”

Section: Introductionmentioning

confidence: 95%

“…The previous research of our group on enhancing the biological activity of CFRPEEK substrate has mainly focused on the UV grafting method as a surface modification method. The UV sensitive gel has been grafted to the surface of CFRPEEK by light cross-linking and concurrent loading of active components to enhance osteogenic activity. ,, In this study, another surface modification method, the chemical grafting method, is used to construct a multifunctional zinc ion sustained-release biocoating, which enriches the research on surface modification of CFRPEEK and hopes to achieve better osseointegration. Meanwhile, our research, which reduces nitrated PEEK with hydrazine hydrate to obtain PEEK-NH 2 , provides a new approach for grafting amino groups onto the surface of PEEK using chemical methods.…”

Section: Introductionmentioning

confidence: 99%

“…The multifunctional surface modification of CFRPEEK as implants should comprehensively consider the biological processes closely related to osteogenesis, including the immuno-inflammatory response, angiogenesis, and bone regeneration. 22 As an essential trace element with major biological functions, zinc participates in the constitution of some key enzymes and transcription factors and contributes to maintaining the balance of bone metabolism. 23,24 The lack of zinc ions will hinder normal bone development and lead to abnormal mineralization and osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

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Construction of Multifunctional Zinc Ion Sustained-Release Biocoating on the Surface of Carbon Fiber Reinforced Polyetheretherketone with Enhanced Anti-inflammatory Activity, Angiogenesis, and Osteogenesis

Zhao

Dong

Wang

et al. 2023

ACS Appl. Mater. Interfaces

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Current treatments of carbon fiber-reinforced polyetheretherketone (CFRPEEK) as orthopedic implants remain unsatisfactory due to the bioinert surface. The multifunctionalization of CFRPEEK, which endows it with regulating the immune inflammatory response, promoting angiogenesis, and accelerating osseointegration, is critical to the intricate bone healing process. Herein, a multifunctional zinc ion sustained-release biocoating, consisting of a carboxylated graphene oxide, zinc ion, and chitosan layer, covalently grafts on the surface of amino CFRPEEK (CP/GC@Zn/CS) to coordinate with the osseointegration process. The release behavior of zinc ions theoretically conforms to the different demands in the three stages of osseointegration, including the burst release of zinc ions in the early stage (7.27 μM, immunomodulation), continuous release in the middle stage (11.02 μM, angiogenesis), and slow release in the late stage (13.82 μM, osseointegration). In vitro assessments indicate that the multifunctional zinc ion sustained-release biocoating can remarkably regulate the immune inflammatory response, decrease the oxidative stress level, and promote angiogenesis and osteogenic differentiation. The rabbit tibial bone defect model further confirms that, compared to the unmodified group, the bone trabecular thickness of the CP/GC@Zn/CS group increases 1.32-fold, and the maximum push-out force improves 2.05-fold. In this study, a multifunctional zinc ion sustained-release biocoating constructed on the surface of CFRPEEK that conforms to the requirements of different osseointegration stages can be an attractive strategy for the clinical application of inert implants.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Construction of Multifunctional Zinc Ion Sustained-Release Biocoating on the Surface of Carbon Fiber Reinforced Polyetheretherketone with Enhanced Anti-inflammatory Activity, Angiogenesis, and Osteogenesis

Zhao

Dong

Wang

et al. 2023

ACS Appl. Mater. Interfaces

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“…8 PEEK and PEEK composites also have well-known biocompatibility, inherent radiolucency, and chemical resistance, making them potential implant materials. 9,10 In earlier research, we created 3D needle-punched CF/PEEK composites after our selection of fibers and polymers according to certain scientific approaches, [11][12][13][14][15][16][17][18] that are roughly isotropic in plane and have internal fibers that are randomly oriented. These composites are anticipated to be used in bone plates.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic construction of 3D needle‐punched CF/PEEK composites based on ladybug forewing structure for directional reinforcement

et al. 2023

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Abstract3D needle‐punched CF/PEEK composites are a kind of composites with promising applications in multiple fields, such as implant materials, but their mechanical properties in the Z‐axis and interlaminar are still weak at present. In this study, a bio‐inspired reinforcement structure based on ladybug forewing was developed to achieve directed reinforcement of 3D needle‐punched CF/PEEK composites. Carbon fiber yarns were stitched into the 3D needle‐punched CF/PEEK preforms according to the set structure, and the bio‐inspired CF/PEEK composites were obtained after hot pressing. The interlaminar and in‐plane mechanical properties of the composites were investigated at different stitch lengths. The results showed that the addition of the bio‐inspired structure greatly improved the interlaminar shear strength of the composites, reaching 111.30 MPa, an enhancement of 95.06%. The in‐plane mechanical properties, including tensile, flexural, and compression, were also significantly improved to different degrees. The “structure‐effect” relationship in the bio‐inspired CF/PEEK composites was investigated, and the effectiveness of such a bio‐inspired reinforcement structure was demonstrated. This new reinforcement strategy provides a new idea for the improvement of the mechanical properties of multi‐stage carbon fiber‐reinforced thermoplastic resin matrix composites.Highlights The in‐plane and interlaminar mechanical properties of composites were simultaneously improved. Up to 95.06% improvement in interlaminar shear strength. A novel bionic strategy of directional reinforcement was developed. The “structure‐effect” relationship in the composites was investigated.

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“…Our previous research on surface modification of CFRPEEK has mainly focused on the ultraviolet (UV) grafting method, based on free radical photopolymerization of methacrylic acid compounds and PEEK, loading bioactive molecules by gel to improve osseointegration. 4,50,51 In this study, we propose a surface chemical modification strategy to construct a sustainrelease SIM system on the surface of CFRPEEK (SCP/SIM/ CPN), which enriches our research on the CFRPEEK surface modification. Based on the Friedel−Crafts reaction between PEEK and succinic anhydride, carboxylated CFRPEEK is prepared to adsorb SIM through the surface pore structure.…”

Section: Introductionmentioning

confidence: 99%

Chemical Modification Strategy to Improve Biological Activity of Carbon Fiber-Reinforced Poly(ether ether ketone) Implants

Zhao

Dong

Wang

et al. 2023

ACS Appl. Polym. Mater.

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Carbon fiber-reinforced poly(ether ether ketone) (CFRPEEK) composite materials, with good biocompatibility and human cortical bone-like elastic modulus, are considered as possible orthopedic implants. However, the inert surface caused inadequate osseointegration, which has limited the clinical application of CFRPEEK in the field of bone implants. To address this issue, a surface chemical modification strategy is proposed to construct a simvastatin (SIM) sustained-release system on the surface of CFRPEEK to promote angiogenesis and osteogenesis. Based on the Friedel–Crafts reaction between PEEK and succinic anhydride, carboxylated CFRPEEK is prepared to adsorb SIM through the surface pore structure, then chitosan/amino-terminated poly(ethylene glycol) (CS/PEG-NH2) (CPN) as a biocoating is covalently grafted on the surface to prevent the rapid diffusion of SIM (SCP/SIM/CPN). In vitro assays indicate that SCP/SIM/CPN exhibits the long-term sustained-release capability of SIM, good hydrophilicity, biomineralization capability, and excellent angiogenesis and bone regeneration/osseointegration. In addition, the rat subcutaneous implantation model confirms that surface modification improves the immunofluorescence intensity of VEGF and CD31 in the surrounding tissues of the implant by 1.65 and 1.60 times after 7 days of implantation, respectively. The rat cranial defect model further substantiates that, compared to the unmodified group, the bone mineral density and bone volume/total volume of the SCP/SIM/CPN group, respectively, increase by 1.84-fold and 1.58-fold after 12 weeks of implantation. This study has attempted to construct a drug sustained-release system on the surface of CFRPEEK by the chemical modification strategy to improve its osseointegration and angiogenesis features, and SCP/SIM/CPN as prepared has potential application in bone tissue engineering.

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Stimuli-responsive metal–organic framework hydrogels endow long carbon fiber reinforced polyetheretherketone with enhanced anti-inflammatory and angiogenesis and osteogenesis

Cited by 16 publications

References 62 publications

Construction of Multifunctional Zinc Ion Sustained-Release Biocoating on the Surface of Carbon Fiber Reinforced Polyetheretherketone with Enhanced Anti-inflammatory Activity, Angiogenesis, and Osteogenesis

Construction of Multifunctional Zinc Ion Sustained-Release Biocoating on the Surface of Carbon Fiber Reinforced Polyetheretherketone with Enhanced Anti-inflammatory Activity, Angiogenesis, and Osteogenesis

Biomimetic construction of 3D needle‐punched CF/PEEK composites based on ladybug forewing structure for directional reinforcement

Chemical Modification Strategy to Improve Biological Activity of Carbon Fiber-Reinforced Poly(ether ether ketone) Implants

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