Stimuli‐Induced Core–Corona Inversion of Micelle of Poly(acrylic acid)‐block‐Poly(N‐isopropylacrylamide) and Its Application in Drug Delivery

Abstract

Core-corona inversion of micelles of diblock copolymer poly(acrylic acid)-block -poly(N-isopropylacrylamide) (PAA-b -PNIPAM), has been successfully realized by switching either pH or temperature. The strong interaction of doxorubicin with the PAA block and the pH-sensitive drug release from the polymer make the system very useful as a controlled drug delivery system. The encapsulation of hydrophobic Nile Red molecules above the lower critical solution temperature of PNIPAM suggests that this polymer may be useful for removing hydrophobic pollutants.

Multi-responsive fluorescence of amphiphilic diblock copolymer containing carboxylate azobenzene and N-isopropylacrylamide

“…Owing to the existence of thermoresponsive PNIPAm block, the fluorescence of PNIPAm-bPM6AzCOONa would depend on temperature. As mentioned above, fluorescence intensity of the block copolymer was closely related to its aggregation state, which could be controlled by water solubility and protonation-deprotonation equilibrium of the azobenzene block under different pH values [49,50]. Similarly, the solubility change of thermoresponsive PNIPAm block should also have significant impact on the aggregate of the block copolymer, and accordingly exert influence on the fluorescence property.…”

“…On account of the presence of carboxyl groups in the azobenzene moieties, the aggregation should be pH-sensitive, which could also influence the fluorescence properties of the block copolymer [49,50]. Accordingly, we studied its fluorescence emission and UVeVis absorption spectra in aqueous solution at different pH values, as shown in Fig.…”

Templated Synthesis for Nanoarchitectured Porous Materials

“…The use of highly biocompatible and biodegradable polymeric micelles offer many advantages over the conventional ways of taking medicine, which include improved efficacy, reduced toxicity, enhanced bio-distribution and improved patient compliance. 126,127 Recently, Yamauchi and co-workers have utilized spherical polymeric micelles consisting of triblock copolymers (e.g., poly(styrene-b-2-vinylpyridine-b-ethylene oxide) (PS-b-PVP-b-PEO)) with three chemically distinct units ( Figure 11). 128130 The PVP block interacts strongly with the inorganic precursors.…”

An in vitro focus on doxorubicin hydrochloride delivery of novel pH‐responsive poly(2‐succinyloxyethylmethacrylate) and poly[(N‐4‐vinylbenzyl),N,N‐diethylamine] diblock copolymers

“…Due to the powerful controlled release ability, easy preparation and low cost, the aforementioned procedure could be a potential candidate in controllable drug delivery and cancer therapy. The strong interaction of DOX with the pH‐responsive blocks and the pH‐sensitive drug release from polymer makes the system very useful as a controlled drug delivery system …”