Stimulatory effect of saponin from Panax ginseng on immune function of lymphocytes in the elderly

Liu, Junda; Wang, Shu; Liu, Hongtao; Yang, Liping; Guo, Nan

doi:10.1016/0047-6374(95)01618-a

Cited by 58 publications

(34 citation statements)

References 8 publications

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“…포닌 또는 진세노사이드로 알려져 있는데, 면역체계 활성화 (Liu et al, 1995), 항암 (Shin et al, 2000;Yun et al, 2001), 혈당 조절 (Dey et al, 2003), 항고지혈 (Kim and Park, 2003), 정력증강 (de Andrade et al, 2007), 스트레스 완화 (Wang and Lee, 2000), 간과 신장 보호 (Kang et (Kwon et al, 1991(Kwon et al, , 1998(Kwon et al, , 2003. (Goulão et al, 2001).…”

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Analysis of Genetic Polymorphism of Korean Ginseng Cultivars and Foreign Accessions using SSR Markers

Bang¹,

Jo²,

Chung³

et al. 2011

Korean Journal of Medicinal Crop Science

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: In this study, simple sequence repeat (SSR) analyses were utilized for evaluation of genetic diversity and discrimination of 17 accessions. Five cultivars, which were developed from Korea, and 12 foreign accessions, which were collected from China, Japan, Russia and USA, were evaluated by nine markers out of 22 SSR markers. A total of 39 alleles were detected, ranging from 2 to 8, with an average of 4.3 alleles per locus. The expected heterozygosity and PIC values were 0.627 and 0.553, with a range from 0.21 (GB-PG-078) to 0.76 (GB-PG-142) and from 0.19 (GB-PG-078) to 0.70 (GB-PG-142), respectively. Four makers out of nine SSR markers, GB-PG-026, GB-PG-043, GB-PG-142 and GB-PG-177, were selected as key factors for discrimination of Korean ginseng cultivars and foreign accessions. All of Korean ginseng cultivars and foreign accessions were individually by the combination of four SSR markers. Consequently, the SSR markers developed in this study may prove useful for the evaluation of genetic diversity and discrimination of Korean ginseng cultivars and foreign accessions.

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Analysis of Genetic Polymorphism of Korean Ginseng Cultivars and Foreign Accessions using SSR Markers

Bang¹,

Jo²,

Chung³

et al. 2011

Korean Journal of Medicinal Crop Science

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“…S. rebudiana dervied extracts are considered rich sources of saponin like phytoconstituents which have shown potent immunostimulating effects. (Shibata 1977;Liu et al 1995;Verotta et al 2001). Reduction in paw oedema may be due to the action of various enzymes and hormones that increase phagocytosis, which activate macrophages on the invader.…”

Section: Discussionmentioning

confidence: 99%

Comparative phytochemical analysis andin vivoimmunomodulatory activity of various extracts ofStevia rebaudianaleaves in experimental animal model

Shukla̽

Mehta

2014

Frontiers in Life Science

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The present study was undertaken to explore the comparative phytochemical analysis and immunomodulating activities of various successively extracted leaf extracts of Stevia rebaudiana (Bertoni) in albino rats. Phytochemical screening conducted on various organic leaf extracts of S. rebaudiana revealed the presence of several biologically active molecules that include sterols, saponins, alkaloids, glycosides, phenols, tannins, flavonoids and resins. The immunomodulatory activities were determined by neutrophil adhesion test, haemagglutination antibody (HA) titre delayed type hypersensitivity (DTH) response and phagocytic activity. The response produced by oral administration of ethanolic and aqueous leaf extracts showed a significant increase in neutrophil adhesion and DTH response. The augmentation of humoral immune response to sheep red blood cells by ethanolic and aqueous extracts at 300-500 mg kg -1 was higher than when an extract dose of 200 mg kg -1 was used, as shown by a dose-related increase in antibody titres in experimental rats. This study demonstrates potent immunomodulatory activities and therapeutic potential of phytochemical compounds extracted from S. rebaudiana leaf to combat against immunological disorders.

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“…Approximately 12 species have been described in the Panax genus, but there are 3 species (Panax ginseng, P. quinquefolius, P. notoginseng) cultivated because of their economic value and used mostly as ingredients for herbal medicine and processed ginseng products (Wen and Zimmer, 1996). Among them, P. ginseng differs from the other 2 species in various proven efficacies, including activation of the immune system (Liu et al 1995), anticancer effects (Shin et al 2000;Yun et al 2001), blood glucose regulation (Dey et al 2003), antihyperlipidemic activity , increased stamina (De Andrade et al 2007), stress relief (Wang and Lee, 2000), and liver and kidney protection (Kang et al 2007). Ginseng is a perennial crop with a simple morphology that makes it difficult to create or select cultivars, and thus about 20 cultivars have been developed in Korea (15 cultivars) and China (5 cultivars), relying on pure line isolation (Jo et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity and population structure of Chinese ginseng accessions using SSR markers

Park

Hong

et al. 2017

J Plant Biotechnol

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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract The need to preserve and use plant genetic resources is widely recognized, and the prospect of dwindling plant genetic diversity, coupled with increased demands on these resources, has made them a topic of global discussion. In the present study, the genetic diversity and population structure of 73 ginseng accessions collected from six regions in China were analyzed using eight simple sequence repeat (SSR) markers. Major allele frequencies ranged between 0.380 .78, with a mean allele frequency value of 0.571. The number of alleles discovered ranged from 3 to 10 per accession, with a mean number of 7; 56 alleles were discovered in total. Gene diversity (GD) and polymorphic information content (PIC) values were similar to each other, and they ranged from 0.36 0.77 (mean 0.588) and 0.33~0.74 (mean 0.548), respectively. Accessions were divided into three clusters based on their phylogenetic relationships and genetic similarities, and although the populations were similar, they were not classified according to the region. Regional genetic diversity was also similar, with slight differences observed based on the number of accessions per region. It is expected that the findings of the present study can provide basic data for future studies on ginseng genetic diversity and for breeding ginseng cultivars.

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Stimulatory effect of saponin from Panax ginseng on immune function of lymphocytes in the elderly

Cited by 58 publications

References 8 publications

Analysis of Genetic Polymorphism of Korean Ginseng Cultivars and Foreign Accessions using SSR Markers

Analysis of Genetic Polymorphism of Korean Ginseng Cultivars and Foreign Accessions using SSR Markers

Comparative phytochemical analysis andin vivoimmunomodulatory activity of various extracts ofStevia rebaudianaleaves in experimental animal model

Genetic diversity and population structure of Chinese ginseng accessions using SSR markers

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