Stimulative effects of Drynariae Rhizoma extracts on the proliferation and differentiation of osteoblastic MC3T3-E1 Cells

Jeong, Ji‐Cheon; Lee, Jae‐Wook; Yoon, Cheol Yong; Lee, Young Choon; Chung, Kang-Hyun; Kim, Min-Gon; Kim, Cheorl-Ho

doi:10.1016/j.jep.2004.09.038

Cited by 63 publications

(40 citation statements)

References 21 publications

(23 reference statements)

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“…Rhizoma Drynariae and its bioactive constituents were able to promote the osteoblastic proliferation, differentiation, and maturation (56,58,59,(62)(63)(64)(65)(66)(67)(68)(69)(70), inhibit osteoblastic apoptosis (71), suppress osteoclastogenesis (72)(73)(74), promote the apoptosis of osteoclasts (60), stimulate both cellular and humoral immunity (75), and inhibit cathepsins K processing (76,77).…”

Section: In Vitro Preclinical Datamentioning

confidence: 99%

Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism

Lin

Wang

Zhang

et al. 2017

BST

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Section: In Vitro Preclinical Datamentioning

confidence: 99%

Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism

Lin

Wang

Zhang

et al. 2017

BST

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“…sinense on osteoblastic MC3T3-E1 cells racemosa (Ranunculaceae) (Chan et al, 2008), safflower seeds (Asteraceae) (Kim et al, 2008), Ulmus davidiana Planch (Ulmaceae) (Kang et al, 2006), Drynaria fortunei (Drynariaceae) (Jeong et al, 2004), Drynariae Rhizoma (Drynariaceae) (Jeong et al, 2005), soybean isoflavones (Choi et al, 2001;Suh et al, 2003), and Homalomena occulta (Homalomenae) (Hu et al, 2008) have been proved to be functional to promote osteogenesis. The purpose of this study is to explore the pharmacological mechanism of PAF to promote the healing of bone fracture by analyzing the proliferation and differentiation of osteoblastic MC3T3-E1 cell.…”

Section: Research Articlementioning

confidence: 99%

Stimulative effects ofPolygonum amplexicaulevar.sinenseon osteoblastic MC3T3-E1 cells

Xiang¹,

Su²,

Hu³

et al. 2011

Pharmaceutical Biology

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“…Current research on rhizoma drynariae extract indicated that it can enhance the proliferation and osteogenic differentiation of the MC3T3-E1 cell line [15] and inhibit osteoclast formation [16]. Based on the above, it seems that rhizoma drynariae has the potential therapeutic function for osteolysis-induced aseptic loosening.…”

Section: Introductionmentioning

confidence: 95%

Inhibiting wear particles-induced osteolysis with naringin

Zhao²,

et al. 2012

International Orthopaedics (SICOT)

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Purpose The purpose of this study was to determine the effects of naringin on osteoclastogenesis and osteolysis both in vitro and in vivo. Methods In this research osteoclasts were generated from mouse bone marrow monocytes with the receptor activator of NF-КB ligand and the macrophage colony stimulating factor. Naringin, at a concentration of 1, 10, 50, and 100 μg/ mL, was respectively added to the medium. Seven days later, the osteoclasts were determined through tartrateresistant acid phosphatase (TRAP) staining. Mature osteoclasts were isolated from newborn rabbits and cultured for three days on bone slices. Naringin at a concentration of 1, 10, 50, and 100 μg/mL was respectively added to the medium. The resorption bone slices were quantified, and the area was calculated after toluidine blue and Mayerhematoxylin staining. Polymethyl methacrylate (PMMA) particles were implanted on the calvariae of C57BL/J6 mice. Naringin, at a dose of 50 μg/kg and 100 μg/kg, was respectively given intraperitoneally for seven. Seven days later, the calvariae were removed and processed for pathological analysis.Results The result indicated that naringin treatment effectively inhibited in vitro osteoclastogenesis and inhibited mature osteoclasts. In vivo data indicated that naringin strongly inhibited PMMA-induced osteolysis. Conclusion Naringin can effectively inhibit osteoclastogenesis and suppress wear particles-induced osteolysis and might be useful in the treatment or prevention of wear particles-induced osteolysis and aseptic loosening for its effect on osteoclast generation and function.

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Stimulative effects of Drynariae Rhizoma extracts on the proliferation and differentiation of osteoblastic MC3T3-E1 Cells

Cited by 63 publications

References 21 publications

Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism

Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism

Stimulative effects ofPolygonum amplexicaulevar.sinenseon osteoblastic MC3T3-E1 cells

Inhibiting wear particles-induced osteolysis with naringin

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