Stimulative effects of cadmium on bone resorption in neonatal pariental bone resorption

Miyahara, Tatsuro; Takata, Masasuke; Mori-Uchi, Sayuri; Miyata, Masaki; Nagai, Miyuki; Segure, Akemi; Matsusista, Mari; Kono, Hiroshi; Kuze, Shougo

doi:10.1016/0300-483x(92)90173-c

Cited by 24 publications

(8 citation statements)

References 13 publications

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“…However, at the molecular level, the effects of cadmium on bone tissue need further clarification. Cadmium stimulated bone resorption by the up-regulation of the production of prostaglandin E 2 in osteoblasts through enhanced expression of phospholipase A 2 and cyclooxygenase (Miyahara et al 1992). Exposure of human osteoblast-like cells to cadmium also produced an increase in cas-pase-3 activity and nuclear changes characteristic of apoptosis, including marginalization and condensing of chromatin and DNA fragmentation (Coonse et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Bone Resorption and Environmental Exposure to Cadmium in Women: A Population Study

Schutte

Nawrot

Richart

et al. 2008

Environ Health Perspect

195

116

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BackgroundEnvironmental exposure to cadmium decreases bone density indirectly through hypercalciuria resulting from renal tubular dysfunction.ObjectiveWe sought evidence for a direct osteotoxic effect of cadmium in women.MethodsWe randomly recruited 294 women (mean age, 49.2 years) from a Flemish population with environmental cadmium exposure. We measured 24-hr urinary cadmium and blood cadmium as indexes of lifetime and recent exposure, respectively. We assessed the multivariate-adjusted association of exposure with specific markers of bone resorption, urinary hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP), as well as with calcium excretion, various calciotropic hormones, and forearm bone density.ResultsIn all women, the effect sizes associated with a doubling of lifetime exposure were 8.4% (p = 0.009) for HP, 6.9% (p = 0.10) for LP, 0.77 mmol/day (p = 0.003) for urinary calcium, –0.009 g/cm2 (p = 0.055) for proximal forearm bone density, and –16.8% (p = 0.065) for serum parathyroid hormone. In 144 postmenopausal women, the corresponding effect sizes were –0.01223 g/cm2 (p = 0.008) for distal forearm bone density, 4.7% (p = 0.064) for serum calcitonin, and 10.2% for bone-specific alkaline phosphatase. In all women, the effect sizes associated with a doubling of recent exposure were 7.2% (p = 0.001) for urinary HP, 7.2% (p = 0.021) for urinary LP, –9.0% (p = 0.097) for serum parathyroid hormone, and 5.5% (p = 0.008) for serum calcitonin. Only one woman had renal tubular dysfunction (urinary retinol-binding protein > 338 μg/day).ConclusionsIn the absence of renal tubular dysfunction, environmental exposure to cadmium increases bone resorption in women, suggesting a direct osteotoxic effect with increased calciuria and reactive changes in calciotropic hormones.

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Section: Discussionmentioning

confidence: 99%

Bone Resorption and Environmental Exposure to Cadmium in Women: A Population Study

Schutte

Nawrot

Richart

et al. 2008

Environ Health Perspect

195

116

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“…This is may be due to the release of Ca from maternal bone, under the effect of Cd, and its transfer to the neonate by lactation [9] . Previous studies performed in vitro indicate that Cd increases the release of Ca from the neonatal bone [19][20][21] . In our study, no differences in Ca concentration in both plasma and femur were noted at any stages except on day 10 when we noted a signifi cant increase of these parameters.…”

Section: Discussionmentioning

confidence: 99%

Lactational Transfer of Cadmium from <i> Meriones shawi shawi</i> Mothers to Their Pups and Its Effects on Calcium Homeostasis and Bone Calcium in Pups

Haouem

Sakly²

2005

Ann Nutr Metab

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Cadmium (Cd) was given to Meriones shawi shawi dams in the diet (1 g CdCl₂/1.5 kg of diet) from day 1 to day 21 of lactation. Pups were killed at 5, 10, 14 and 21 days of lactation. Thereafter, liver, kidney, femur and stomach content were removed and plasma was collected to element analyses. Cd in stomach content, kidney, liver and femur and calcium (Ca) in stomach content, femur and plasma were determined in pups by atomic absorption spectrophotometer. The results indicate that Cd was transferred to the suckling and it was detected in the liver, the kidney and the femur from the 5th, the 10th and the 14th days of age, respectively. Stomach content of Ca was increased significantly from the 10th day to the end of lactation, whereas Ca levels increase in plasma and femur only at day 10 of lactation.

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“…It has been indicated that Cd exposure could affect metabolic biomarker of bone resorption (Åkesson et al, 2006;Sughis et al, 2011). In addition, several organ culture systems also indicate that Cd stimulates bone resorption (Suzuki et al, 1989(Suzuki et al, , 1990Miyahara et al, 1992Miyahara et al, , 2001Wang et al, 1994). Microarray analysis shows that bone demineralization stimulated by Cd is related with osteoclast activation (Regunathan et al, 2003).…”

Section: Introductionmentioning

confidence: 96%

Environmental level of cadmium exposure stimulates osteoclasts formation in male rats

Chen

Wang

Xu-fang

et al. 2013

Food and Chemical Toxicology

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Stimulative effects of cadmium on bone resorption in neonatal pariental bone resorption

Cited by 24 publications

References 13 publications

Bone Resorption and Environmental Exposure to Cadmium in Women: A Population Study

Bone Resorption and Environmental Exposure to Cadmium in Women: A Population Study

Lactational Transfer of Cadmium from <i> Meriones shawi shawi</i> Mothers to Their Pups and Its Effects on Calcium Homeostasis and Bone Calcium in Pups

Environmental level of cadmium exposure stimulates osteoclasts formation in male rats

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