Stimulation of the Basal Nucleus of Meynert in Senile Dementia of Alzheimer’s Type

Turnbull, I. M.; McGeer, Patrick L.; Beattie, L.; Calne, D. B.; Pate, B. D.

doi:10.1159/000101130

Cited by 50 publications

(65 citation statements)

References 10 publications

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“…These trials can be divided into the following 5 categories of surgical approaches: cerebrospinal fluid (CSF) shunting [4,5,6,7], intraventricular infusions [8,9,10,11,12,13,14,15,16], tissue grafting [17,18,19], gene therapy [20,21], and electrical neural stimulation [22,23,24,25,26] (table 1). The specific treatment strategies within each category are described in detail below (table 2).…”

Section: Methodsmentioning

confidence: 99%

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The Neurosurgical Treatment of Alzheimer's Disease: A Review

Laxton

Stone

Lozano

2014

Stereotact Funct Neurosurg

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Background: Alzheimer's disease (AD) is a debilitating neurological illness of increasing prevalence. Because many patients are affected and current treatments have limited effectiveness, other therapeutic strategies are urgently needed. Objectives: Here we provide a review of the neurosurgical approaches that have been attempted or are currently being investigated for the treatment of AD. Methods: Computerized database searches identified all of the published studies in the English-language literature examining the surgical treatment of AD since 1950. Results: The following 5 categories of neurosurgical treatment were identified: cerebrospinal fluid shunting, intraventricular infusions, tissue grafting, gene therapy, and electrical neural stimulation. Conclusions: While none of the neurosurgical approaches applied to the treatment of AD have proven effective to date, recent trials involving gene therapy and electrical neural stimulation are showing promising early results. Larger trials investigating these treatments have been proposed or are currently under way.

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Section: Methodsmentioning

confidence: 99%

“…Turnbull et al [23] were the first to report the effects of NBM DBS in an AD patient. These researchers implanted a DBS electrode in the patient's left NBM.…”

Section: Published Human Trials Of Neurosurgical Treatments For Admentioning

confidence: 99%

The Neurosurgical Treatment of Alzheimer's Disease: A Review

Laxton

Stone

Lozano

2014

Stereotact Funct Neurosurg

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“…In 1984 Turnbull unilaterally implanted a flexible electrode into the left NBM via a frontal approach in a 74-year old patient with clinically moderate AD [22]. Based on animal studies, activation of NBM can enhance the behavioral state and thereby boost a range of mental faculties including memory, attention and perception.…”

Section: Nucleus Basalis Of Meynertmentioning

confidence: 99%

Deep Brain Stimulation for Alzheimer's Disease

Lavano¹,

Torre²

2016

Brain Disord Ther

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Alzheimer's disease (AD) is a debilitating neurological illness of increasing prevalence. Accumulations of abnormal proteins (beta amyloid and tau protein), inflammatory cascades, abnormal responses to oxidative stress and alteration in oxidative metabolism have been implicated in AD. There are few therapeutic options available for this disorder. Latest research indicates that deep brain stimulation (DBS) may be a method for improving cognitive functions. Many aspects remain unclear, particularly with regard to the optimal target structure. In this review the pathophysiology, neural circuitry and potential neuromodulation options in patients with AD are resumed.

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“…In a case report published in 1985-prior to the current modern era of DBS-Turnbull et al [19] were the first to target this region, implanting a stimulating electrode in the left NBM in a single patient with AD. Stimulation was applied in a cyclic fashion for 9 months.…”

Section: Nucleus Basalis Of Meynert Stimulationmentioning

confidence: 99%

Deep Brain Stimulation for Disorders of Memory and Cognition

2014

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The next several decades will see an exponential rise in the number of patients with disorders of memory and cognition, and of Alzheimer's disease in particular. Impending demographic shifts, an absence of effective treatments, and the significant burden these conditions place on patients, caregivers, and society, mean there is an urgent need to develop novel therapies. Deep brain stimulation (DBS) is a neurosurgical procedure that is a standard-of-care for many patients with treatment-refractory Parkinson's disease, dystonia, and essential tremor. DBS has proven to be an effective means of modulating activity in disrupted motor circuitry, and has shown promise as a modulator of other dysfunctional circuits, including for mood and anxiety disorders. The deficits in Alzheimer's disease and other disorders of memory and cognition are also beginning to be thought of as arising from dysfunction in neural circuits. Such dysfunction may be amenable to modulation using focal brain stimulation. A global experience is now emerging for the use of DBS for these conditions, targeting key nodes in the memory circuit, including the fornix and nucleus basalis of Meynert. Such work holds promise as a novel therapeutic approach for one of medicine's most urgent priorities.

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Stimulation of the Basal Nucleus of Meynert in Senile Dementia of Alzheimer’s Type

Cited by 50 publications

References 10 publications

The Neurosurgical Treatment of Alzheimer's Disease: A Review

The Neurosurgical Treatment of Alzheimer's Disease: A Review

Deep Brain Stimulation for Alzheimer's Disease

Deep Brain Stimulation for Disorders of Memory and Cognition

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