Deep Brain Stimulation for Disorders of Memory and Cognition

Sankar, Tejas; Lipsman, Nir; Lozano, Andrés M.

doi:10.1007/s13311-014-0275-0

Cited by 33 publications

(20 citation statements)

References 48 publications

(50 reference statements)

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“…Although there have been prior reviews on deep brain stimulation (Lee, Fell, & Axmacher, 2013;Sankar, Lipsman, & Lozano, 2014;Suthana & Fried, 2014), a comprehensive review that summarizes successful and unsuccessful invasive and non-invasive stimulation approaches to memory modulation is current lacking. A critical review of prior work may help design optimal strategies for determining both stimulation targets and patterns of stimulation that could successfully and reliably modulate human memory.…”

Section: Introductionmentioning

confidence: 99%

A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory

Kim¹,

Ekstrom

Tandon³

2016

Neurobiology of Learning and Memory

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A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. that disrupting frontal or parietal regions also impairs memory performance, suggesting that these regions also play necessary roles in declarative memory. On the other hand, a handful of both invasive and non-invasive studies have also suggested modest improvements in memory performance following stimulation. These studies typically target brain regions connected to the hippocampus or other memory "hubs," which may affect endogenous activity in connected areas like the hippocampus, suggesting that to augment declarative memory, altering the broader endogenous memory network activity is critical. Together, studies reporting memory improvements / impairments are consistent with the idea that a network of distinct brain "hubs" may be crucial for successful memory encoding and retrieval rather than a single primary hub such as the hippocampus. Thus, it is important to consider neurostimulation from the network perspective, rather than from a purely localizationalist viewpoint. We conclude by proposing a novel approach to neurostimulation for declarative memory modulation that aims to facilitate interactions between multiple brain "nodes" underlying memory rather than considering individual brain regions in isolation.

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Section: Introductionmentioning

confidence: 99%

A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory

Kim¹,

Ekstrom

Tandon³

2016

Neurobiology of Learning and Memory

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“…While DBS is currently an FDA-approved therapy only for PD, essential tremor, and dystonia, it is being piloted as a therapy for numerous other neurological disorders such as medication-resistant depression, Tourette syndrome, epilepsy, and neuropsychiatric disorders [40]–[43]. For many of these disorders, symptom characterization is more challenging than it is in PD.…”

Section: Discussionmentioning

confidence: 99%

Neurofeedback Control in Parkinsonian Patients Using Electrocorticography Signals Accessed Wirelessly With a Chronic, Fully Implanted Device

Khanna

Swann

Hemptinne

et al. 2017

IEEE Trans. Neural Syst. Rehabil. Eng.

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Parkinson’s disease (PD) is characterized by motor symptoms such as rigidity and bradykinesia that prevent normal movement. Beta band oscillations (13–30 Hz) in neural local field potentials (LFPs) have been associated with these motor symptoms. Here, three PD patients implanted with a therapeutic deep brain neural stimulator that can also record and wirelessly stream neural data played a neurofeedback game where they modulated their beta band power from sensorimotor cortical areas. Patients’ beta band power was streamed in real-time to update the position of a cursor that they tried to drive into a cued target. After playing the game for 1–2 hours each, all three patients exhibited above chance-level performance regardless of subcortical stimulation levels. This study, for the first time, demonstrates using an invasive neural recording system for at-home neurofeedback training. Future work will investigate chronic neurofeedback training as a potentially therapeutic tool for patients with neurological disorders.

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“…Certaines maladies neurologiques ou neuropsychiatriques sont en effet clairement liées au dysfonctionnement de sous-circuits neuronaux particuliers, comme en témoignent un certain nombre d'études ayant employé des stimulations électriques profondes chez l'homme [5][6][7][8]. Cependant, les possibilités d'interventions ciblées à l'aide des techniques actuelles de neuromodulation sont fortement limitées.…”

Section: Principes Et Avantages De La Neuromodulation Optogénétiqueunclassified

Potentiel thérapeutique de la neuromodulation optogénétique

et al. 2015

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Deep Brain Stimulation for Disorders of Memory and Cognition

Cited by 33 publications

References 48 publications

A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory

A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory

Neurofeedback Control in Parkinsonian Patients Using Electrocorticography Signals Accessed Wirelessly With a Chronic, Fully Implanted Device

Potentiel thérapeutique de la neuromodulation optogénétique

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