Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies

Qu, Aihua; Sun, Maozhong; Kim, Ji-Young; Xu, Liguang; Hao, Changlong; Ma, Wei; Wu, Xiaoling; Liu, Xiaogang; Kuang, Hua; Kotov, Nicholas A.

doi:10.1038/s41551-020-00634-4

Cited by 120 publications

(126 citation statements)

References 43 publications

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“…Within the same year, Xu 9 and coworkers reported a DNA-bridged chiral assembly of L-/D-Cys coated gold nanoparticles (CAM), which can accelerate differentiation of neural stem cells (NSCs) into neurons under CPL (Figure 6 D). By entangling the cells' cytoskeletal fibres, this Au-based chiral NPs can exert the CPL-dependent force on the cytoskeleton, thus accelerate the differentiation of neural stem cells into neurons.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…For example, the helical SiO 2 nanostructures can behave biomimically which in return leads stem cell commitment into osteoblast lineage 8 . Similarly, the differentiation of neural stem cells into neurons can be accelerated by circularly polarized photons when DNA-bridged chiral assemblies of gold nanoparticles are entangled with the cells' cytoskeletal fibres 9 . In fact, chiral structures can function synergistically.…”

Section: Introductionmentioning

confidence: 99%

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Shining light on chiral inorganic nanomaterials for biological issues

et al. 2021

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The rapid development of chiral inorganic nanostructures has greatly expanded from intrinsically chiral nanoparticles to more sophisticated assemblies made by organics, metals, semiconductors, and their hybrids. Among them, lots of studies concerning on hybrid complex of chiral molecules with achiral nanoparticles (NPs) and superstructures with chiral configurations were accordingly conducted due to the great advances such as highly enhanced biocompatibility with low cytotoxicity and enhanced penetration and retention capability, programmable surface functionality with engineerable building blocks, and more importantly tunable chirality in a controlled manner, leading to revolutionary designs of new biomaterials for synergistic cancer therapy, control of enantiomeric enzymatic reactions, integration of metabolism and pathology via bio-to nano or structural chirality. Herein, in this review our objective is to emphasize current research state and clinical applications of chiral nanomaterials in biological systems with special attentions to chiral metal- or semiconductor-based nanostructures in terms of the basic synthesis, related circular dichroism effects at optical frequencies, mechanisms of induced optical chirality and their performances in biomedical applications such as phototherapy, bio-imaging, neurodegenerative diseases, gene editing, cellular activity and sensing of biomarkers so as to provide insights into this fascinating field for peer researchers.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Shining light on chiral inorganic nanomaterials for biological issues

et al. 2021

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“…Chiral nanostructures [ 1–6 ] have attracted significant levels of attention over the last decade due to their potential applications in oxidation prevention, [ 2 ] DNA cleavage, [ 7 ] drug delivery, [ 8 ] chiral sensing, [ 9 ] and the treatment of Alzheimer's disease (AD), [ 10 ] and so on. [ 4,11,12 ] Among these chiral nanomaterials, chiral plasmonic nanostructures have displayed beneficial optical properties due to their strong optical activity and unique surface plasmon resonance (SPR). Furthermore, these features can be tuned by changing the size or morphology of the nanostructures.…”

Section: Introductionmentioning

confidence: 99%

Chiral Plasmonic Triangular Nanorings with SERS Activity for Ultrasensitive Detection of Amyloid Proteins in Alzheimer's Disease

Wang

Hao

et al. 2021

Advanced Materials

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Chiral plasmonic nanomaterials have attracted unprecedented attention due to their broad applications in biomedicine, negative refractive index, and chiral sensing. Here, using a wet‐chemistry process, chiral triangular Au nanorings are fabricated with a platinum (Pt) framework (l/d‐Pt@Au triangular nanorings, named l/d‐Pt@Au TNRs). The l/d‐Pt@Au TNRs exhibit strong optical activity with a g‐factor of 0.023 and can be used effectively for the discrimination of enantiomers due to selective resonance coupling between the induced electric and magnetic dipoles associated with enantiomers and the chiral plasmonic TNRs, also known as the surface‐enhanced Raman scattering‐chiral anisotropy (SERS‐ChA) effect. The chiral d‐Pt@Au TNRs represent a label‐free SERS platform that can be applied to detect Aβ monomers and fibrils, the hallmarks of Alzheimer's disease (AD), achieving a limit of detection (LOD) down to 0.045 × 10−12 m and 4 × 10−15 m for 42‐residue‐long amyloid‐β (Aβ42) monomer and fibrils, respectively. Furthermore, chiral d‐Pt@Au TNRs can also be successfully carried out to detect Aβ42 proteins in AD patients with ultrahigh levels of sensitivity, thus allowing picogram quantities of Aβ42 proteins to be identified. This research opens up an avenue for the use of chiral plasmonic nanomaterials as ultrasensitive SERS substrates to early diagnosis of protein‐misfolding diseases.

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“…Owing to their flexible and adjustable scale,optical signals and synthesis strategies,chiral inorganic nanostructures have been widely used for catalysis, [15][16][17] bio-sensing, [18][19][20] and investigating the interactions between chiral nanomaterials and biological systems. [21][22][23][24] More importantly,r esearch has proved that nanomaterials with opposing chirality tend to induce different biological effects.F or example, d-Cu x Co y S NPs exhibited an internalization ability that was 2-fold higher than that of l-Cu x Co y SNPs. [23] It is vital that NPs are selected with the correct chirality for subsequent biological application.…”

Section: Introductionmentioning

confidence: 99%

Improved Reactive Oxygen Species Generation by Chiral Co₃O₄ Supraparticles under Electromagnetic Fields

Wang

Sun

et al. 2021

Angew Chem Int Ed

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One of the most common methods to treat thromboembolism is the use of thrombolytic drugs to activate fibrinolytic protease.T he aim of this treatment was to initiate the lysis of fibrin;h owever,t here are many side-effects associated with this form of treatment. Herein, we fabricated chiral Co 3 O 4 supraparticles (SPs) with ag-factor of up to 0.02 at 550 nm and paramagnetic performance applied in the treatment of thromboembolism under an electromagnetic field (MF). In vitro experiments showed that d-SPs degraded blood clot within 8hours under MF.C ompared to l-SPs, d-SPs exhibited muchs tronger thrombolytic ability and effectively enhanced the survival rate of thrombosis model mice more than 70 %inthe 25 dofobservation. The results of mechanism study showed that under MF,t he level of reactive oxygen species (ROS) produced by d-SPs were 1.5 times higher than that of l-SPs,w hichm ight be attributed to the chiral-induced spin selectivity effects. Scheme 1. A) Illustration of chiral Co 3 O 4 SPs@PM preparation process and B) underlying mechanism of thrombolysis therapy by chiral Co 3 O 4 SPs@PM.

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Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies

Cited by 120 publications

References 43 publications

Shining light on chiral inorganic nanomaterials for biological issues

Shining light on chiral inorganic nanomaterials for biological issues

Chiral Plasmonic Triangular Nanorings with SERS Activity for Ultrasensitive Detection of Amyloid Proteins in Alzheimer's Disease

Improved Reactive Oxygen Species Generation by Chiral Co₃O₄ Supraparticles under Electromagnetic Fields

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Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies

Cited by 120 publications

References 43 publications

Shining light on chiral inorganic nanomaterials for biological issues

Shining light on chiral inorganic nanomaterials for biological issues

Chiral Plasmonic Triangular Nanorings with SERS Activity for Ultrasensitive Detection of Amyloid Proteins in Alzheimer's Disease

Improved Reactive Oxygen Species Generation by Chiral Co3O4 Supraparticles under Electromagnetic Fields

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Improved Reactive Oxygen Species Generation by Chiral Co₃O₄ Supraparticles under Electromagnetic Fields