Stimulation of myocardial neutral triglyceride lipase activity by adenosine-3’:5’-monophosphate: involvement of glycogenolysis

Schoonderwoerd, Kees; Broekhoven-Schokker, S.; Hülsmann, W.C.; Stam, H.

doi:10.1007/978-3-662-08390-1_4

Cited by 7 publications

(5 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, the presence of a hormone sensitive triglyceride lipase (3,7,9,17,26) activated by an increase in cytosolic cAMP or Ca 2+ levels as a consequence of the endogenous release of catecholamines occurring during ischemia or anoxia (9,19,32). However, in our opinion the evidence for the existence of a hormone-sensitive lipase is not convincing since the observed activation of neutral lipase activity by cAMP was due to an enhanced glycogenolysis (33). Furthermore the activation of a hormone-sensitive lipase does not play a role in enhanced lipolysis during ischemia/anoxia because there was no change in lipolysis using different Ca 2+ concentrations during anoxia (results not shown).…”

Section: Discussionmentioning

confidence: 78%

“…We propose that the withdrawal of inhibitory free fatty acids would mainly be determined by the rate of reesterification, which is regulated by the tissue NADH/NAD + ratio. Recently we have shown that the observed activation of neutral lipase activity by cAMP was due to enhanced glycogenolysis, delivering glycerol-3-phosphate for reesterification of the inhibitory free fatty acids (33). During ischemia and anoxia beta-oxidation is hampered and the rates of glycogenolysis and glycolysis are enhanced.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Enhanced lipolysis of myocardial triglycerides during low-flow ischemia and anoxia in the isolated rat heart

et al. 1989

Self Cite

View full text Add to dashboard Cite

We studied lipolysis in the isolated rat heart, measured as glycerol release during anoxia, low-flow ischemia and subsequent reperfusion. It was found that the rate of lipolysis was enhanced during ischemia/anoxia while the lipase activities in tissue extracts involved in the myocardial lipolysis and the amount of triglycerides were not affected. This indicates the dominant occurrence of a lipolysis-reesterification principle in ischemic and anoxic tissue. A common observation of ischemia/anoxia is an increase in the tissue NADH/NAD+ ratio. Therefore we investigated the effect of lactate and malate, both of which enhance the tissue redox state on myocardial lipolysis. Perfusion in the presence of lactate (10 mM) and malate (10 mM) both stimulated myocardial lipolysis by about five times. This suggests that the rate of reesterification of product fatty acids to triglycerides, which is determined by the NADH/NAD+ ratio, because of the increased formation of glycerol 3-phosphate from dihydroxy acetone phosphate, plays an important role in the regulation of lipolysis. The existence of triglyceride-fatty acid-triglyceride cycle is discussed.

show abstract

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 98%

Enhanced lipolysis of myocardial triglycerides during low-flow ischemia and anoxia in the isolated rat heart

et al. 1989

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is probably related to hormonesensitivity of glycogenolysis [8,9] which, while providing glycerol-3-P serves as acceptor of activated fatty acids, stimulates removal of these inhibitory products during lipolysis [10,11]. The present paper shows that TNF acutely stimulates cardiac glycogenolysis, and thereby endogenous lipolysis.…”

Section: Introductionmentioning

confidence: 70%

“…Removal of glycogen from cell-free homogenates resulted in alleviation of stimulation of lipolysis by cyclic AMP [9]. The higher sensitivity of TNF stimulation of endogenous lipolysis in trierucate-fed animals is probably due to the abundant presence of cardiac triacylglycerol [11,13].…”

Section: Discussionmentioning

confidence: 97%

Effects of tumor necrosis factor (TNF) on lipolytic activities of rat heart

Hülsmann

Dubelaar

1988

Mol Cell Biochem

View full text Add to dashboard Cite

Tumor Necrosis Factor (TNF) inhibits lipoprotein lipase activity in cultured myocytes and in the Langendorff rat heart after 3 h perfusion with TNF of glucocorticoid-pretreated rats. TNF acutely stimulates glyc(ogen)olysis and concomitantly endogenous lipolysis. The latter was significantly increased only when rats had been pretreated with glucocorticoid or fed a trierucate-rich diet. Under these conditions, contractile activity of the Langendorff hearts was acutely increased by TNF. The mechanism of the acute increase of contractile function and the accompanying increased glycolytic and lipolytic activities, by TNF, may be explained by increased cytosolic Ca2+ and cAMP levels.

show abstract

“…The action of lysosomal lipases is thought to be responsible for cardiac endogenous triacylglycerol hydrolysis [30], although contribution of neutral lipases cannot be excluded [30][31][32][33][34]. Regulation of the activity of cardiac triacylglycerol hydrolases is achieved by both hormonal and metabolic agents.…”

Section: The Effect Of Lactate On Endogenous Esterified Lipid Storesmentioning

confidence: 99%

Interrelationship between lactate and cardiac fatty acid metabolism

Vusse¹,

Groot

1992

Mol Cell Biochem

View full text Add to dashboard Cite

This overview is presented, in the main, to summarize the following aspects of lactate and cardiac fatty acid metabolism: 1. The utilization of exogenous carbohydrates and fatty acids by the heart. 2. The competition between lactate and fatty acids in cardiac energy metabolism. 3. The effect of lactate on endogenous triacylglycerol homeostasis. 4. Lactate-induced impairment of functional recovery of the post-ischemic heart. 5. The effect of lactate on lipid metabolism in the ischemic and post-ischemic heart. 6. The consequences of hyperlactaemia for cardiac imaging.

show abstract

Stimulation of myocardial neutral triglyceride lipase activity by adenosine-3’:5’-monophosphate: involvement of glycogenolysis

Cited by 7 publications

References 14 publications

Enhanced lipolysis of myocardial triglycerides during low-flow ischemia and anoxia in the isolated rat heart

Enhanced lipolysis of myocardial triglycerides during low-flow ischemia and anoxia in the isolated rat heart

Effects of tumor necrosis factor (TNF) on lipolytic activities of rat heart

Interrelationship between lactate and cardiac fatty acid metabolism

Contact Info

Product

Resources

About