Effects of tumor necrosis factor (TNF) on lipolytic activities of rat heart

Hülsmann, W.C.; Dubelaar, Marie-Louise

doi:10.1007/bf02424557

Cited by 9 publications

(3 citation statements)

References 29 publications

(32 reference statements)

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“…55,56 TNF also inhibited LPL activity in cultured myocytes and in the Langendorff rat heart. 57 In cultures of a human osteosarcoma cell line, rh-TNF-a suppressed synthesis, activity, and secretion of LPL and inhibited LPLmediated supply of non-esterified fatty acids as an energy source for growth, which might partly account for the antiproliferative activity of TNF-a. 58 Furthermore, a synergism between interferon gamma and TNF-a in the regulation of LPL in the macrophage J774.2 cell line was observed.…”

Section: Effects Of Tnf-a On Lipid-metabolism-related Enzymesmentioning

confidence: 98%

TNF‐α, a potent lipid metabolism regulator

Chen

Xun

Chen³

et al. 2009

Cell Biochemistry & Function

190

120

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As a multifunctional cytokine, tumor necrosis factor alpha (TNF-a) exerts a series of biological actions in different cells, tissues, organs, and species and has been demonstrated to regulate and interfere with energy metabolism, especially lipid homeostasis. A large body of researches suggested that the effects of TNF-a on lipid metabolism mainly include five aspects: (1) suppresses free fatty acid (FFA) uptake and promotes lipogenesis; (2) induces lipolysis; (3) inhibits lipid-metabolism-related enzymes activity; (4) regulates cholesterol metabolism; (5) regulates other adipocyte-derived adipokines. The molecular mechanisms underlying these actions are complex and several signal transduction pathways might be involved. Regulation of metabolism-related gene expression at transcriptional and protein levels and impact on enzymes activity might be of importance. Identification and verification of these pathways might provide novel potential strategies and drug targets for dyslipidemia therapy. However, the inconsistent and even conflict conclusions on lipid profile drawn from human subjects after infliximab therapy poses the possibility that the effect of TNF-a on lipid metabolism might be more complicated than it appeared to be.

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Section: Effects Of Tnf-a On Lipid-metabolism-related Enzymesmentioning

confidence: 98%

TNF‐α, a potent lipid metabolism regulator

Chen

Xun

Chen³

et al. 2009

Cell Biochemistry & Function

190

120

View full text Add to dashboard Cite

show abstract

“…Given that a decrease in epididymal adipose tissue LPL activity has always been observed, the role of LPL in the onset and maintenance of hypertriacylglycerolaemia following TNF injection or tumour growth may be largely determined by the response of muscle. TNF has been reported to increase [12,14], to decrease [32] or not to change [13,15,16] LPL activity in muscle.…”

Section: Discussionmentioning

confidence: 99%

Regulation of lipoprotein lipase activity and mRNA content in rat epididymal adipose tissue in vitro by recombinant tumour necrosis factor

Mackay

Oliver

Rogers

1990

Biochemical Journal

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Tumour necrosis factor (TNF) has previously been shown to decrease lipoprotein lipase (LPL) activity and mRNA levels in 3T3-L1 cells and in adipose tissue from rats and guinea pigs when injected in vivo, but not to alter LPL activity in human adipocytes incubated in vitro. The effect of recombinant human TNF on LPL activity and mRNA levels in rat epididymal adipose tissue incubated in vitro was examined. LPL activity and mRNA levels fell in adipose tissue taken from fed rats and incubated in Krebs-Henseleit bicarbonate medium with glucose. The addition of insulin and dexamethasone prevented these falls. TNF (400 ng/ml) produced a fall of approx. 50% in LPL activity after 2 h of incubation and of approx. 30% in LPL mRNA levels after 3 h. TNF did not decrease LPL activity in isolated adipocytes. These results demonstrate that rat adipose tissue incubated in vitro is responsive to TNF whereas isolated adipocytes are not.

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“…232 TNF-␣, IL-6, IL-1␣, LMF, and IFN-␣ and IFN-␥ inhibit lipoprotein lipase (LPL) (an enzyme necessary for lipogenesis and mobilization of fatty acids from triglycerides and involved in extraction of fatty acids from plasma lipoproteins for storage). [233][234][235][236][237][238][239] Cytokines also induce lipolysis and ␤-oxidation. 240 LMP increases oxidation of the released fatty acids through an induction of UCP expression.…”

Section: Fatty Tissue Oxidationmentioning

confidence: 99%