TNF‐<i>α</i>, a potent lipid metabolism regulator

Chen, Xiuping; Xun, Keli; Chen, Lidian; Wang, Ying

doi:10.1002/cbf.1596

Cited by 186 publications

(129 citation statements)

References 127 publications

(130 reference statements)

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“…Inflammatory conditions under bacterial or viral infections were found to result in an increase in the serum concentration of triglycerides and a decrease in the serum HDL-cholesterol in humans (17,18). Multiple cytokines are likely to affect the metabolism of cholesterol or triglycerides through several pathways, including the increased production and decreased clearance of very low-density lipoproteins, impaired reverse cholesterol transport and decreased excretion of bile acids (16,(19)(20)(21). We now showed that rs6929846 of BTN2A1 was significantly associated with hypertriglyceridemia in Japanese and Korean populations and with reduced serum concentrations of HDL-cholesterol in Japanese individuals, with the minor T allele representing a risk factor for these conditions.…”

Section: Discussionmentioning

confidence: 99%

Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations

Fujimaki

Kato

Oguri³

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. We previously identified rs6929846 of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) as a susceptibility locus for myocardial infarction in Japanese individuals by a genome-wide association study. The aim of the present study was to examine the relation of the rs6929846 polymorphism of BTN2A1 to dyslipidemia in Japanese and Korean populations, given that dyslipidemia is an important risk factor for myocardial infarction. A total of 10,953 individuals from three independent subject panels were examined. The relations of the rs6929846 polymorphism of BTN2A1 to serum concentrations of triglycerides, high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol were examined in each subject panel. The C→T polymorphism (rs6929846) of BTN2A1 was significantly associated with serum concentrations of triglycerides in Japanese subject panels A (P=0.0004) and B (P=0.0010), and in the Korean population (P=0.0095), with the minor T allele being related to an increased serum concentration of triglycerides. The rs6929846 was associated with serum concentrations of HDL-cholesterol in Japanese subject panels A (P=0.0047) and B (P=0.0015), with the T allele being related to a decreased serum concentration of HDL-cholesterol, but not in the Korean population. This polymorphism was associated with the serum concentration of LDL-cholesterol only in Japanese subject panel B (P=0.0059), with the T allele being related to an increased serum concentration of LDL-cholesterol. The results suggest that BTN2A1 may be a susceptibility gene for hypertriglyceridemia in East Asian populations and for low serum HDL-cholesterol in the Japanese population.

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Section: Discussionmentioning

confidence: 99%

Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations

Fujimaki

Kato

Oguri³

et al. 2011

Experimental and Therapeutic Medicine

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“…1). It is known from the lite rature data that an increase of TNFα secretion under adipose tissue hypertrophy induces lipolysis that causes the increase of FFA pool and their ex-екСпериМентальні роботи cessive income to the liver, where they are involved in the TAG synthesis [17,18]. Beside the activation of TAG synthesis in the liver, the overproduction of TNFα leads to the decrease of TAG-enriched VLDL clearance that is associated with its inhibiting effect on lipoprotein lipase [19].…”

Section: Resultsmentioning

confidence: 99%

The effect of N-stearoylethanolamine on plasma lipid composition in rats with experimental insulin resistance

Onopchenko¹

2015

Ukr.Biochem.J.

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“…Another important factor that directly acts on adipocyte metabolism is TNF-α. It stimulates lipolysis, increases free fatty acid production (Chen et al, 2009) and promotes leptin release from adipocytes (Simons et al, 2005). TNF-α can be secreted by the adipose tissue itself and it can metabolically promote negative energy balance (Galic et al, 2010) by paracrine functions.…”

Section: Discussionmentioning

confidence: 99%

Anterior pituitary influence on adipokine expression and secretion by porcine adipocytes

Saleri

Cavalli

Martelli

et al. 2016

Animal

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Nutritional stressors may cause negative effects on animal health and growth and lead to significant economic impact. Adipose tissue is an endocrine organ producing, mediators and hormones, called adipokines. They play a dynamic role in body homeostasis and in the regulation of energy expenditure, interacting with feeding behavior, hormones and growth factors. This in vitro study aimed to investigate how nutritional conditions and growth hormone (GH) can influence nitric oxide (NO) production and the expression and secretion of three important adipokines, that is leptin, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), by swine adipocytes. In our experimental model, mesenchymal stem cells from omental adipose tissue were induced to adipogenic differentiation. After differentiation, adipocytes were incubated for 24 h (T0) with DMEM/Ham's F12 (group A) or DMEM/Ham's F12 salts (group B), a DMEM/Ham's F12 formulation deprived of nutritional components. Primary adipocyte cells were also co-cultured for 4 h (T + 4) or 12 h (T + 12) with or without anterior pituitary slices. To stimulate GH secretion by pituitary cells, growth hormone releasing hormone at 10 − 8 M was added at the start of the incubation times (4 or 12 h). At T0, T + 4 and T + 12, NO production, leptin, IL-6 and TNF-α expression and secretion were measured. NO increased ( P < 0.05) up to twofold in restricted culture conditions. Deprived medium and coincubation with anterior pituitary positively influenced leptin secretion and expression. TNF-α was expressed and secreted only in deprived culture condition groups (B, B1 and B2). Nutrients availability and pituitary co-culture did not affect IL-6 expression and secretion. Our study shows an endocrine function for porcine adipocytes. In our model, adipocytes readily responded to nutritional inputs by secretion of molecules affecting energy balance. This secretion capacity was modulated by GH. Improving our knowledge of the role of adipocyte in the endocrine system, may lead to a more complete understanding of regulating energy balance in swine.

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TNF‐α, a potent lipid metabolism regulator

Cited by 186 publications

References 127 publications

Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations

Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations

The effect of N-stearoylethanolamine on plasma lipid composition in rats with experimental insulin resistance

Anterior pituitary influence on adipokine expression and secretion by porcine adipocytes

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