“…Neuronal networks produced in cell cultures provide tremendous potential for investigation of synapse formation, development, and function (Gross et al, 1977;Gross et al, 1979;Pine et al, 1980;Grattarola et al, 1993;Gross et al, 1993;Potter et al, 2001;Corner et al, 2002;Marom et al, 2002;van Pelt et al, 2004;Gramowski et al, 2005). Planar microelectrode arrays (MEAs) provide a means for long-term, simultaneous recording of electrical activities from neural networks (Jimbo et al, 1992;James at al., 2004;Chang et al, 2001;Maher et al, 1999).…”