Stimulation of Intestinal Immune Cells By E. coli in Gnotobiotic Piglets

Escherichia coli strains colonising the gastrointestinal tract protect germfree mice against Salmonella typhimurium infection

“…We showed that both EM0 and JM105 strains translocated from the gastrointestinal tract to the MLN, as found previously by others for indigenous E coli strains in mice50 51 and piglets 4552 The clinical significance of translocation of indigenous bacteria and its role in priming the host immune response to improve host defences against overt or opportunistic pathogen(s) is not yet known 50. Some authors have reported that E coli participates in the establishment of the population of IgA plasmocytes in the lamina propria in adult germfree mice, in suckling mice,53 and in germfree piglets52 to the level obtained in conventional animals.…”

“…52 The clinical significance of translocation of indigenous bacteria and its role in priming the host immune response to improve host defences against overt or opportunistic pathogen(s) is not yet known 50. Some authors have reported that E coli participates in the establishment of the population of IgA plasmocytes in the lamina propria in adult germfree mice, in suckling mice,53 and in germfree piglets52 to the level obtained in conventional animals. E coli EM0 has several immunological properties whereas those of E coli K-12 have not yet been well studied.…”

Probiotics: Properties, Examples, and Specific Applications

“…Although the molecular mechanisms by which EcN exerts its beneficial effects are largely unknown (Schultz and Lindstrom 2008), several studies have tried to understand what makes EcN a probiotic. Because EcN administration alleviates gastrointestinal tract inflammatory disorders and is highly protective against pathogenic bacteria and fungi including Listeria monocytogenes, Candida albicans, and Salmonella enterica serovar Typhimurium (Hockertz 1991(Hockertz , 1997Mandel et al 1995), one might expect that this probiotic strain would down-regulate inflammation. However, there is strong evidence that this bacterium instead enhances the host cell-mediated response, leading to a modulation of the balance between both pro-and anti-inflammatory local cytokines (Fig.…”

Modulation of natural immunity in the gut by Escherichia coli strain Nissle 1917

“…EcN interferes with the invasion of human intestinal epithelial cells by different enteroinvasive bacterial pathogens, 29 as well as by STEC 28 . EcN shows an antagonistic effect against enteropathogenic bacteria (Figure 2) in vivo in gnotobiotic pigs, and EcN from fecal samples of gnotobiotic pigs is antagonistic against enterobacteria 31,32 . It has been found that oral treatment of germ‐free pigs with EcN for 1 week protected the animals against subsequent infection with EPEC (enteropathogenic O55 strain of E. coli ) (Splichalova et al.…”