Stimulation of gastric acid secretion and intestinal motility by Vernonia amygdalina extract

Owu, Daniel U.; Ben, Ezekiel E.; Antai, A. B.; Ekpe, E.A.; Udia, P. M.

doi:10.1016/j.fitote.2007.07.011

Cited by 7 publications

(6 citation statements)

References 14 publications

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“…Gastric acid secretion was measured in all groups of animals by a continuous perfusion method as previously reported (26). Briefly, after an overnight fast, anaesthesia was induced using 25% urethane at a dose of 6 ml/kg bodyweight intraperitoneally.…”

Section: Gastric Acid Secretion Studymentioning

confidence: 99%

Effect of Gongronema latifolium Ethanol Leaf Extract on Gastric Acid Secretion and Cytoprotection in Streptozotocin-induced Diabetic Rats

Owu

Nwokocha²,

Obembe³

et al. 2012

West Indian Med J

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Objectives: Gongronema latifolium leaves have been used in folklore medicine to manage diabetes mellitus and alleviate dyspepsia. This study aimed to provide a pharmacological basis to the medicinal use of Gongronema latifolium as an antidiabetic and antiulcerogenic agent in diabetes mellitus. Methods: Ethanol extract from the leaf (200 mg/kg bodyweight) of Gongronema latifolium was administered to both streptozotocin-induced diabetic and control groups orally for 14 days. Gastric acid secretion was measured and ulcer was induced using ethanol and four-hour pyloric ligation. Results: The mean bodyweight was significantly lower (p < 0.01), while the mean weight of the stomach, liver and small intestine to bodyweight ratio was increased significantly (p < 0.05) in the two diabetic groups compared to control. Extract significantly (p < 0.01) reduced the blood glucose level similar to the non-diabetic control. Basal and stimulated acid secretion in diabetic control rats was significantly (p < 0.01) decreased when compared to control. Extract administration increased the stimulated gastric acid secretion to a level significantly (p < 0.05) higher than control while reduction in gastric secretion by ranitidine was similar compared with control. Gongronema latifolium treatment significantly (p < 0.05) reduced ulcer scores in both ulcer models and increased mucus weight in the diabetic group. Conclusion: These results suggest that Gongronema latifolium antiulcerative activity is due to its prevention of chemical-induced stomach injury.

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Section: Gastric Acid Secretion Studymentioning

confidence: 99%

Effect of Gongronema latifolium Ethanol Leaf Extract on Gastric Acid Secretion and Cytoprotection in Streptozotocin-induced Diabetic Rats

Owu

Nwokocha²,

Obembe³

et al. 2012

West Indian Med J

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“…The leaves are boiled in soups and are also sold in the market after being shredded, parboiled, and made into fist-sized balls. 17 Aqueous extracts of V. amygdalina have been shown to have antibacterial, 41 , 42 amebicidal, 43 antioxidant, 44 , 45 hypoglycemic/antidiabetic, 46 oxytocic, 47 hepatoprotective, 48 serum lipid modulatory, 49 gastric secretory, 50 analgesic, 41 and phytotoxic 43 efficacies. Also, earlier investigators have shown that purified fractions of the chloroform extract of V. amygdalina elicited anticancer effects in human carcinoma of the nasopharynx.…”

Section: Niger-vamentioning

confidence: 99%

“… 51 The leaves, harvested for human consumption and washed to get rid of the bitter taste, are often eaten as a vegetable, one known to stimulate the gastrointestinal tract and reduce fever. 50 Leaves are also used as a local medicine against schistosome worm transmitting leeches in treating amoebic dysentery, 54 , 55 malaria, some sexually transmitted diseases, wounds, and hepatitis. 56 In-depth studies of V. amygdalina (VA) identified nine important minerals in the plant leaves, including zinc, magnesium, iron, copper, and others, as well as condensed tannins and soluble tannins.…”

Section: Niger-vamentioning

confidence: 99%

Recent perspectives on the anticancer properties of aqueous extracts of Nigerian Vernonia amygdalina

Howard¹,

Johnson²,

Pervin³

et al. 2015

BTAT

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Innovative developments are necessary for treating and defeating cancer, an oftentimes deadly group of diseases characterized by the uncontrolled growth and spread of abnormal cells. Breast cancer (BC) is the second leading cause of cancer-related deaths of women in the USA, and prostate cancer (PC) is the second leading cause of cancer-related deaths of American men. Although some efficacious BC drugs are pharmaceutically marketed, they affect the quality of life for some patients because they are toxic in that their usages have been accompanied by side effects such as stroke, thrombosis, slow heart rate, seizure, increased blood pressure, nausea, emesis, and more. Therefore, there is an urgent need for the discovery of molecular markers for early detection of this disease and discovery of targets for the development of novel, less toxic therapeutics. A botanical plant Vernonia amygdalina has been widely used in Nigerian and other Central and West African cultures for centuries as an herbal medicine. Mounting evidence suggests that treatment with low concentrations of aqueous leaf extracts of the edible Nigerian V. amygdalina plant (Niger-VA) arrests the proliferative activities and induces apoptosis in estrogen receptor-positive, estrogen receptor-negative, and triple-negative human breast cancerous cells and in androgen-independent human PC-3. Also, in athymic mice, Niger-VA potentiates increased efficacies and optimizes treatment outcomes when given as a cotreatment with conventional chemotherapy drugs. Evidence of its noticeable cytostatic activities ranging from changes in DNA synthesis to growth inhibition, mechanisms of inducing apoptosis in different cancer cell lines, and in vivo antitumorigenic activities and chemopreventive efficacy reinforce the idea that Niger-VA deserves increased attention for further development as a phytoceutical, anticancer drug entity. Hence, the present review article highlights impactful published literature on the anticancer effects of Niger-VA in multiple cancerous cell lines and in a nude mouse model, supporting its potential usefulness as a natural product, chemotherapeutic medicine for treatment of both BC and PC.

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“…Various human and animal model studies indicate that stomach motility can be stimulated by capsaicin (from the chilli pepper Capsicum annuum), 68 as well as Vernonia amygdalina leaf extracts, 69 the mixed-extract herbal formulation known as Iberogast (also known as STW 5) which includes components such as Citrus limonum, Glycyrrhiza glabra, Mentha piperita and Matricaria recutita, 70 and ginger (Zingiber officinale) extracts, 71 while diarrhoea can be caused by Cassia angustifolia (senna) extract. 72 Furthermore, a common use for Aloe vera is as a laxative.…”

Section: Interactions Affecting Drug Absorptionmentioning

confidence: 99%

The safe usage of herbal medicines: counterindications, cross-reactivity and toxicity

Cock¹

2014

Phcog Commn.

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Background: Plants have been used therapeutically for thousands of years and continue to be the main treatment modality for a large percentage of the world's population. Furthermore, herbal medicine usage is increasing in Western countries as complementary (and sometimes alternative) treatments in conjunction with allopathic medicine. At the same time, the usage of allopathic medicines is being increasingly incorporated into the medicinal systems of developing countries, often resulting in the concurrent usage of both systems. Importance of the Study: Despite the widespread usage in developing countries and the trend of increasing medicinal plant usage in Western countries, herbal medicines remain understudied and there are misunderstandings amongst users and practitioners about the safe usage of these medications, particularly when used in conjunction with other medicines. Herbal medicines are generally not held to the same rigorous standards as allopathic medicines. There is usually a lack of industry regulation and manufacturing standards and guidelines, resulting in inferior (or unsafe) medicines being sold to consumers. Similarly, there is a lack of understanding amongst many medical practitioners of both traditional and allopathic medicine systems of how drugs from the two systems can be safely used together. Aim: The aim of this review is to summarise the current knowledge about herbal medicines and how they can be used safely, with the aim of not only highlighting some of the unsafe uses, but also to stimulate further research. I have also aimed to highlight the need for greater regulation and standardisation of herbal medicines.

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Stimulation of gastric acid secretion and intestinal motility by Vernonia amygdalina extract

Cited by 7 publications

References 14 publications

Effect of Gongronema latifolium Ethanol Leaf Extract on Gastric Acid Secretion and Cytoprotection in Streptozotocin-induced Diabetic Rats

Effect of Gongronema latifolium Ethanol Leaf Extract on Gastric Acid Secretion and Cytoprotection in Streptozotocin-induced Diabetic Rats

Recent perspectives on the anticancer properties of aqueous extracts of Nigerian Vernonia amygdalina

The safe usage of herbal medicines: counterindications, cross-reactivity and toxicity

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