Stimulation of Ca2+ influx in rat pituitary cells under exposure to a 50 Hz magnetic field

Barbier, Élisabeth; Dufy, B; Veyret, B.

doi:10.1002/(sici)1521-186x(1996)17:4<303::aid-bem6>3.0.co;2-7

Cited by 87 publications

(27 citation statements)

References 31 publications

(10 reference statements)

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“…Experiments with different cell types consistently point to the Ca 2ϩ signaling system as the primary cellular target of MF interactions (5,10,23,52,53,60,69,86,87). In many cases, alternating MFs alone or in combination with static fields increase intracellular Ca 2ϩ , as, for instance, in HL60 cells (10), T-lymphocytes and leukemia cells (60), the human T cell line (Jurkat) (55,56), bone cells (23), pituitary cells (5), and human astrocytoma cells (69).…”

Section: Physiological Effects Of Mf Exposurementioning

confidence: 99%

Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli

Gartzke

Lange²

2002

American Journal of Physiology-Cell Physiology

102

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Gartzke, Joachim, and Klaus Lange. Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli. Am J Physiol Cell Physiol 283: C1333-C1346, 2002; 10.1152/ajpcell. 00167.2002.-The interaction of weak electromagnetic fields (EMF) with living cells is a most important but still unresolved biophysical problem. For this interaction, thermal and other types of noise appear to cause severe restrictions in the action of weak signals on relevant components of the cell. A recently presented general concept of regulation of ion and substrate pathways through microvilli provides a possible theoretical basis for the comprehension of physiological effects of even extremely low magnetic fields. The actin-based core of microfilaments in microvilli is proposed to represent a cellular interaction site for magnetic fields. Both the central role of F-actin in Ca 2ϩ signaling and its polyelectrolyte nature eliciting specific ion conduction properties render the microvillar actin filament bundle an ideal interaction site for magnetic and electric fields. Ion channels at the tip of microvilli are connected with the cytoplasm by a bundle of microfilaments forming a diffusion barrier system. Because of its polyelectrolyte nature, the microfilament core of microvilli allows Ca 2ϩ entry into the cytoplasm via nonlinear cable-like cation conduction through arrays of condensed ion clouds. The interaction of ion clouds with periodically applied EMFs and field-induced cation pumping through the cascade of potential barriers on the F-actin polyelectrolyte follows well-known physical principles of ion-magnetic field (MF) interaction and signal discrimination as described by the stochastic resonance and Brownian motor hypotheses. The proposed interaction mechanism is in accord with our present knowledge about Ca 2ϩ signaling as the biological main target of MFs and the postulated extreme sensitivity for coherent excitation by very low field energies within specific amplitude and frequency windows. Microvillar F-actin bundles shielded by a lipid membrane appear to function like electronic integration devices for signal-tonoise enhancement; the influence of coherent signals on cation transduction is amplified, whereas that of random noise is reduced. calcium signaling; cell differentiation; Brownian motor hypothesis; cyclotron resonance; hair cell; mechanoelectrical coupling; physiological effects MORE THAN A DECADE OF RESEARCH on field effects in biological systems has yielded rather compelling data for the involvement of the Ca 2ϩ signaling pathway as a primary and main target of magnetic fields (MFs). As first demonstrated by Liburdy and colleagues (52,53) and later on by a number of other authors, the Ca 2ϩ influx pathways of isolated or cultured cells are severely affected by rather low MF energies.The physiological relevance of this finding is high, because Ca 2ϩ represents the most important intracellular signal governing almost all physiological functions in differentiated cells. Most importantly, cytopla...

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Section: Physiological Effects Of Mf Exposurementioning

confidence: 99%

Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli

Gartzke

Lange²

2002

American Journal of Physiology-Cell Physiology

102

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“…Biological effccls of lovv-lVcqticncy magnclic fields on Ca-' oscillations in human leukemic T cells (S<S) as well as ral pituitary cells (89) have also recently been demonstrated. These highly interesting sUidics may provitic lurlhcr undcrslaiiding regarding the molecular mechanisms behind F'lVll'-iiiduced cellul'ar effects.…”

Section: Skin Changes In "Screen Dermafitis"mentioning

confidence: 99%

Skin changes in “screen dermatitis” versus classical UV‐ and ionizing irradiation‐related damage — similarities and differences

Gangi

Johansson

1997

Experimental Dermatology

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Skin changes in ''screen dermatitis" versus classical UV-and ionizing irradiation-related damage -similarities and differences Two neiiroscieiitists' speculative review (jatigi S. .lohanssoti O. Skin cbatiges iti "screen dertnalilis" \orstts classical L'V-atui iotiizing irradialion-rclatcd damage -similarities and dilTcrences. Two tieuroscietilists' speculative rc\ie\v. Exp Dermalol 1997: 6: 28.^ 291. t^ Munksgaard. 1997 Abslracl: Ati increasing tnnnbcr of persotis sa\ thai llic\ gel cutaticous protilctns as well as sympicims ltoni ccrtatti ititcrtial orgatis, sttch as ihe cetitral ncr\otts s_\sleni (CNS) and llio heart, when beitig close lo cicclric cqtiiptiicnt. A major group of Ihcsc patients arc llic users of \ideo display Icrtiiinals (VDTs). who claitn lo ha\e subjcclixc atid objccli\c skinatid tnucosa-related sytnplotiis. sticli as pain. ilcb. heal sctisation. cryllictna, pajiules. and intslulcs. The CNS symplotns arc, e.g. di/ziticss. tiredness, atid headache. Rrylhetna. ilcli. heal sensation, cdenia atid paiti are also ctitiitiioti symploms of stmbttrti (LIV dcrmatilis). Alletalions ha\c been observed iti cell iiopttlaliotis of the skin of paltetils sufferitig Itotii so-called "screen dertnalilis" sitiiilar lo those observed iti llie skiti damaucd due lo itllraviolel (L)V) lighl or ioni/itig tadialion. In "screen dertnalitis" patienls a tiiuch higher number of tnasl cells have bceti cibserxed. Il is known Ihal L'VB irradiation induces tnasl cell degtanulalion and tclease of TNF-K. The high nittiiber of tnasl cells prescnl in llic "setecti dertnalilis" palicnls atid the possible release of specilic substances, such as bistatnitie. may explaiti llieir elitiical sytnptonis of itch, paiti. edema and erythema. The tnost remarkable change among ctilancous cells, afler exposure wilh the above-metitiotieil itfadiatioti sources, is the disappearance of Ihe Latigerhatis" cells. This chatige lias also beeti obscr\ed iti "sereeti dertnalilis" patients, again pointing lo a common cellttkif atid tiiolecular basis. The results of this liletalute study detmnistrale lliat highly sitnilar changes exist in the skiti of "screen dertnalilis" palietils. as tegards the clitiical tnanifestalions as well as allcraliotis iti the cell popttlaliotis. atid in skin damaged by L'V lighl or ionizitig radialioti.

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“…Consistent data have indicated that MFs influence Ca 2ϩ fluxes (12)(13)(14). Intracellular calcium concentration affects many different targets, which change from cell to cell and within cells, leading to cellular function or malfunction.…”

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confidence: 99%

Static magnetic fields affect calcium fluxes and inhibit stress‐induced apoptosis in human glioblastoma cells

et al. 2002

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Background: Epidemiologic data revealed increased brain tumor incidence in workers exposed to magnetic fields (MFs), raising concerns about the possible link between MF exposure and cancer. However, MFs seem to be neither mutagenic nor tumorigenic. The mechanism of their tumorigenic effect has not been elucidated. Methods: To evaluate the interference of MFs with physical (heat shock, HS) and chemical (etoposide, VP16) induced apoptoses, respectively, we exposed a human glioblastoma primary culture to 6 mT static MF. We investigated cytosolic Ca 2ϩ ([Ca 2ϩ ] i ) fluxes and extent of apoptosis as key endpoints. The effect of MFs on HS-and VP16-induced apoptoses in primary glioblastoma cultures from four patients was also tested. Results: Static MFs increased the [Ca 2ϩ ] i from a basal value of 124 Ϯ 4 nM to 233 Ϯ 43 nM (P Ͻ 0.05). MF exposure dramatically reduced the extent of HS-and

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Stimulation of Ca2+ influx in rat pituitary cells under exposure to a 50 Hz magnetic field

Cited by 87 publications

References 31 publications

Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli

Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli

Skin changes in “screen dermatitis” versus classical UV‐ and ionizing irradiation‐related damage — similarities and differences

Static magnetic fields affect calcium fluxes and inhibit stress‐induced apoptosis in human glioblastoma cells

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