Stimulation of bone formation by zoledronic acid in particle-induced osteolysis

Anabolic effects of bisphosphonates on peri-implant bone stock

“…Specifically, bisphosphonate treatments raised peri-implant cancellous bone volume more than three-fold in the presence of wear particles compared to a two-fold increase in their absence. Supporting this observation, Wedemeyer et al [40] reported pronounced bone formation in a murine calvarial model, 14 days after introduction of particulate debris and zoledronate. The negative effects of wear debris on the recruitment, differentiation, proliferation and activity of osteoblasts have previously been highlighted [41,42].…”

Inhibitory effects of luteolin on titanium particle-induced osteolysis in a mouse model

“…Recent approaches to limiting osteolysis have focused on understanding and manipulating osteolysis at the molecular level through pharmacological interventions [9,10]. Several studies have shown that nitrogen-containing bisphosphonates such as alendronate and zoledronate inhibit wear debris-induced osteolysis and increase peri-implant bone mineral density [11][12][13][14]. However, side-effects, such as fever, throat and stomach ulcers, and the low bioavailability of these drugs limit their use in systemic treatment.…”

Use of medications and risk of revision after primary total hip arthroplasty

“…Oral alendronate treatment protected the dogs from osteoclast mediated bone loss and thus implant loosening (Shanbhag et al, 1997). Further experimental studies have confirmed these finding of inhibited particle induced bone resorption in bisphosphonates treated animals (Millett et al, 2002, von Knoch et al, 2005b, Wedemeyer et al, 2005. However, in all studies wear particles were introduced intraoperatively and treatment with bisphosphonates was initiated directly after surgery.…”

“…This particle induced periprosthetic osteolysis was inhibited by bisphosphonates in experimental studies in dogs (Shanbhag et al, 1997, Millett et al, 2002, von Knoch et al, 2005b, Wedemeyer et al, 2005. However, in a clinical setting of patients with demonstrated aseptic loosening who were awaiting revision surgery, six months treatment with bisphosphonates did not alter the need for revision surgery (Lyons et al, 2009).…”