Anabolic effects of bisphosphonates on peri-implant bone stock

Knoch, Fabian von; Eckhardt, C.; Alabre, Claude I.; Schneider, Erich; Rubash, Harry E.; Shanbhag, Arun S.

doi:10.1016/j.biomaterials.2007.04.024

Cited by 31 publications

(33 citation statements)

References 49 publications

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“…Our results are in agreement with the results from that dose-response study. We could not demonstrate any anabolic effect of zoledronate, as has been suggested by other authors 21 . We chose to soak the allograft in zoledronate even though studies have also shown that a local effect on bone allograft can be achieved by systemic administration of bisphosphonate 22,23 .…”

supporting

confidence: 56%

Preclinical Evaluation of Zoledronate to Maintain Bone Allograft and Improve Implant Fixation in Revision Joint Replacement

Sørensen

Barckman

Bechtold

et al. 2013

The Journal of Bone & Joint Surgery

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supporting

confidence: 56%

Preclinical Evaluation of Zoledronate to Maintain Bone Allograft and Improve Implant Fixation in Revision Joint Replacement

Sørensen

Barckman

Bechtold

et al. 2013

The Journal of Bone & Joint Surgery

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“…[34][35][36] However, undesirable side effects of bisphosphonate-related osteonecrosis of the jaw (BRONJ) were claimed. BRONJ is characterized by the unexpected appearance of necrotic bone in the oral cavity and oncologic patients receiving high doses of BP intravenously are at high risk for its development.…”

Section: Discussionmentioning

confidence: 99%

Promotion of Bone Formation around Alendronate-immobilized Screw-Type Titanium Implants after Implantation into Rat Molar Tooth Sockets

Raita

Komatsu

Nifuji

et al. 2014

J. Hard Tissue Biology.

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The aim of this study was to evaluate the effects of alendronate immobilization on bone formation following the implantation of apatite-coated titanium implants in rats. Thin carbonate-containing apatite coatings were deposited onto titanium implants (Ti implants) using a molecular precursor method. Alendronate was then immobilized on apatite-coated titanium implants (HA implants) by immersing the HA implants in alendronate solution (Ald implants). The rat molars were extracted, and the implants were immediately placed in the tooth sockets. Bone labeling was performed 14 and 7 days before sacrifice. At 3 and 9 weeks after implantation, undecalcified sections were prepared and bone histomorphometry was performed. Greater bone mass was found around the Ald implants than around either the Ti or HA implants at both 3 weeks and 9 weeks. At 3 weeks, fluorochrome bone labeling was greater around the Ald implants than around the Ti implants, and the values of bone to implant contact (BIC) and bone mass (BM) were significantly greater around the Ald implants than around the HA and Ti implants. At 9 weeks, bone labeling decreased and the values of BIC and BM increased compared with those at 3 weeks for all types of implant. In conclusion, we found that immobilized alendronate triggered pronounced bone formation around the implants at an early stage of bone healing. These results suggest that alendronate immobilization accelerates implant fixation early in the healing phase.

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“…The amount of bone surrounding these implants is important for the long-term success of total joint replacement. Periprosthetic fractures and implant loosening due to unsuccessful osseointegration are two modes of failure for total joint arthroplasty that depend on the amount of the surrounding cancellous bone 3–6 . Enhancement of this periprosthetic bone is critical to long-term fixation and ultimate clinical success of a joint replacement surgery 3–6 .…”

Section: Introductionmentioning

confidence: 99%

Intermittent PTH administration and mechanical loading are anabolic for periprosthetic cancellous bone

Grosso

Courtland

Yang

et al. 2014

Journal Orthopaedic Research

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The purpose of this study was to determine the individual and combined effects on periprosthetic cancellous bone of intermittent PTH (iPTH) and mechanical loading at the cellular, molecular, and tissue levels. Porous titanium implants were inserted bilaterally on the cancellous bone of adult rabbits beneath a loading device attached to the distal lateral femur. The left femur received a sham loading device. The right femur was loaded daily, and half of the rabbits received daily PTH. Periprosthetic bone was evaluated up to 28 days for gene expression, histology, and µCT analysis. Loading and iPTH increased bone mass by a combination of two mechanisms: 1) altering cell populations in a pro-osteoblastic/anti-adipocytic direction, and 2) controlling bone turnover by modulating the RANKL-OPG ratio. At the tissue level, BV/TV increased with both loading (+53%, p<0.05) and iPTH (+54%, p<0.05). Combined treatment showed only small additional effects at the cellular and molecular levels that corresponded to a small additive effect on bone volume (+13% compared to iPTH alone, p>0.05). This study suggests that iPTH and loading are potential therapies for enhancing periprosthetic bone formation. The elucidation of the cellular and molecular response may help further enhance the combined therapy and related targeted treatment strategies.

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Anabolic effects of bisphosphonates on peri-implant bone stock

Cited by 31 publications

References 49 publications

Preclinical Evaluation of Zoledronate to Maintain Bone Allograft and Improve Implant Fixation in Revision Joint Replacement

Preclinical Evaluation of Zoledronate to Maintain Bone Allograft and Improve Implant Fixation in Revision Joint Replacement

Promotion of Bone Formation around Alendronate-immobilized Screw-Type Titanium Implants after Implantation into Rat Molar Tooth Sockets

Intermittent PTH administration and mechanical loading are anabolic for periprosthetic cancellous bone

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