Stimulation of 5-HT1B receptors decreases cocaine- and sucrose-seeking behavior

Acosta, Jazmin I.; Boynton, Floren A.; Kirschner, Kenneth F.; Neisewander, Janet L.

doi:10.1016/j.pbb.2004.12.001

Cited by 56 publications

(63 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in apparent contrast to these effects, we found that RU24969 (Acosta et al, 2005) and CP94253 (Pentkowski et al, 2009) dose-dependently decrease cue- and cocaine-primed reinstatement of extinguished cocaine-seeking behavior. The RU24969-induced decreases in reinstatement of cocaine seeking are reversed by the antagonist GR127935, suggesting that they are 5-HT 1B R-mediated.…”

Section: Dysregulation Of 5-ht1brscontrasting

confidence: 84%

“…The RU24969-induced decreases in reinstatement of cocaine seeking are reversed by the antagonist GR127935, suggesting that they are 5-HT 1B R-mediated. Since 5-HT 1B R agonists enhance cocaine reinforcement, we initially thought that the effects of the agonists on cocaine-primed reinstatement (10 mg/kg, IP) resulted from a cocaine-like satiation effect (Acosta et al, 2005). Subsequently, however, we found that CP94253 (10 mg/kg, SC) reduces reinstatement by a lower cocaine priming dose (2.5 mg/kg, IP), which we had predicted would enhance seeking similar to a higher dose of cocaine (Pentkowski et al, 2009).…”

Section: Dysregulation Of 5-ht1brsmentioning

confidence: 99%

“…Several reports suggest that 5-HT 1B R agonists increase spontaneous locomotion in rats (Acosta et al, 2005; Bendotti and Samanin, 1987; Chaouloff et al, 1999; Green et al, 1984; Koe et al, 1992; O’Neill and Parameswaran, 1997; Oberlander et al, 1987) and mice (Chaouloff et al, 1999; Cheetham and Heal, 1993; Goodwin and Green, 1985). In contrast, others have found that acute administration of CP94253 either in rats with a history of cocaine SA (Pentkowski et al, 2009) or in drug naïve rats (Halford and Blundell, 1996; Przegalinski et al, 2007) fails to alter locomotion at doses that alter psychostimulant SA.…”

Section: Dysregulation Of 5-ht1brsmentioning

confidence: 99%

“…Indeed, acute administration of 5-HT 1B R agonists decrease sucrose (10% solution) intake (Lee and Simansky, 1997) and reinstatement of sucrose seeking in free-feeding rats (Acosta et al, 2005), as well as food intake in food-restricted and non-restricted rodents (Bendotti and Samanin, 1987; Halford and Blundell, 1996; Koe et al, 1992; Lee et al, 2002; Nonogaki et al, 2007). In contrast, CP94253 failed to alter reinforcement rates for sucrose or sweetened milk at doses that significantly altered cocaine-seeking behavior (Pentkowski et al, 2009; Przegalinski et al, 2008).…”

Section: Dysregulation Of 5-ht1brsmentioning

confidence: 99%

See 3 more Smart Citations

Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development

2014

Self Cite

View full text Add to dashboard Cite

Addiction to psychostimulants, including cocaine and amphetamine, is associated with dysregulation of dopamine and serotonin (5-HT) neurotransmitter systems. Neuroadaptations in these systems vary depending on the stage of the drug taking-abstinence-relapse cycle. Consequently, the effects of potential treatments that target these systems may vary depending on whether they are given during abstinence or relapse. In this review, we discuss evidence that dopamine D3 receptors (D3Rs) and 5-HT1B receptors (5-HT1BRs) are dysregulated in response to both chronic psychostimulant use and subsequent abstinence. We then review findings from preclinical self-administration models which support targeting D3Rs and 5-HT1BRs as potential medications for psychostimulant dependence. Potential side effects of the treatments are discussed and attention is given to studies reporting positive treatment outcomes that depend on: 1) whether testing occurs during abstinence versus relapse, 2) whether escalation of drug self-administration has occurred, 3) whether the treatments are given repeatedly, and 4) whether social factors influence treatment outcomes. We conclude that D3/D2 agonists may decrease psychostimulant intake; however, side effects of D3/D2R full agonists may limit their therapeutic potential, whereas D3/D2R partial agonists likely have fewer undesirable side effects. D3-selective antagonists may not reduce psychostimulant intake during relapse, but nonetheless, may decrease motivation for seeking psychostimulants with relatively few side-effects. 5-HT1BR agonists provide a striking example of treatment outcomes that are dependent on the stage of the addiction cycle. Specifically, these agonists initially increase cocaine’s reinforcing effects during maintenance of self-administration, but after a period of abstinence they reduce psychostimulant seeking and the resumption of self-administration. In conclusion, we suggest that factors contributing to dysregulation of monoamine systems, including drug history, abstinence, and social context, should be considered when evaluating potential treatments to better model treatment effects in humans.

show abstract

Section: Dysregulation Of 5-ht1brscontrasting

confidence: 84%

Section: Dysregulation Of 5-ht1brsmentioning

confidence: 99%

Section: Dysregulation Of 5-ht1brsmentioning

confidence: 99%

Section: Dysregulation Of 5-ht1brsmentioning

confidence: 99%

See 2 more Smart Citations

Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development

2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Being speculative, one can hypothesize that more efficacious HTR1B transmission might play a protective role in substance dependence disorders, as confirmed by indepen- Fig. 2 (continued) dent studies [1,33,67,98,125,126]. Consistent with this figure, Shippenberg and colleagues reported that the dopamine concentration in the Nacc was higher in HTR1B KO animals than in controls [153], and mice with both HTR1B knocked out showed a shorter latency period in meeting cocaine self-administration criteria [136].…”

Section: Htr1b and Motivationmentioning

confidence: 77%

HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory

Drago

Alboni

Brunello

et al. 2009

Eur J Clin Pharmacol

View full text Add to dashboard Cite

Purpose Serotonin receptor 1B (HTR1B) is involved in the regulation of the serotonin system, playing different roles in specific areas of the brain. We review the characteristics of the gene coding for HTR1B, its product and the functional role of HTR1B in the neural networks involved in motivation and memory; the central role played by HTR1B in these functions is thoroughly depicted and show HTR1B to be a candidate modulator of the mnemonic and motivationally related symptoms in psychiatric illnesses. Methods In order to challenge this assessment, we analyze how and how much the genetic variations located in the gene that codes for HTR1B impacts on the psychiatric phenotypes by reviewing the literature on this topic. Results We gathered partial evidence arising from genetic association studies, which suggests that HTR1B plays a relevant role in substance-related and obsessive compulsive disorders. On the other hand, no solid evidence for other psychiatric disorders was found. This finding is quite striking because of the heavy impairment of motivation and of mnemonic-related functions (for example, recall bias) that characterize major psychiatric disorders. Conclusions The possible reasons for the contrast between the prime relevance of HTR1B in regulating memory and motivation and the limited evidence brought by genetic association studies in humans are discussed, and some suggestions for possible future directions are provided.

show abstract

Neurological repercussions of neonatal nicotine exposure: A review

Xavier

Singh

Kumari

et al. 2021

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Smoking during pregnancy is hazardous to both the mother and the foetus, according to a substantial amount of recorded data. Exposure to nicotine and other compounds in cigarette smoke increases the risk of sudden infant death syndrome (SIDS) by two to five times during pregnancy. Serotonergic abnormalities have been discovered in SIDS infants in the zone of the medulla oblongata, which is known to control cardio‐respiratory function. SIDS establishes a connection between depression, learning difficulties and behavioural disorders. Prenatal nicotine intake during the second trimester affects the dopaminergic neurological system, making the foetal brain more susceptible to nicotine and developing ADHD symptoms not just in a foetus but in adolescents also. Prenatal nicotine exposure alters the neurological route of neurotransmitters, acetylcholine and dopamine. Nicotine enhances neuronal activity in adults but desensitizes these processes in babies and young children exposed prenatally. The impact of a neurotoxin like nicotine is determined by the amount and duration of exposure. Continued exposure throughout pregnancy will influence a wide range of activities in the neurodevelopment, whereas exposure confined to a single stage of pregnancy may only affect the processes that are forming at that stage. To decrease the effect of nicotine on neonates due to maternal smoking strategies like nicotine replacement therapy (NRT), folic acid treatment and other behavioural treatments have been studied. Hence, this review focuses on the impact of exposure to nicotine on neonates, which results in various neurological consequences and smoking cessation therapies.

show abstract

Stimulation of 5-HT1B receptors decreases cocaine- and sucrose-seeking behavior

Cited by 56 publications

References 33 publications

Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development

Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development

HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory

Neurological repercussions of neonatal nicotine exposure: A review

Contact Info

Product

Resources

About