Stilbestrol, Effect of Subcutaneous Implantation on Growing-Fattening Swine

Dinusson, W. E.; Klosterman, E. W.; Buchanan, M. L.

doi:10.2527/jas1951.104885x

Cited by 18 publications

(7 citation statements)

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“…For the boar, Wallace (1949) recorded that the libido of intact mature animals was relatively less adversely affected by stilboestrol implants than by castration. Stilboestrol implantation has been reported to result in regained capability for erection of the penis and in arousal of sexual desire of young, castrated male pigs (Dinusson, Klosterman & Buchanan, 1951). From the present experiment, it was concluded that a synergistic effect was shown for testosterone and oestro¬ gens in improving the libido of castrated boars.…”

Section: Discussionmentioning

confidence: 77%

Synergistic Effects of Testosterone and Oestrogens on Accessory Sex Glands and Sexual Behaviour of the Boar

Joshi¹,

Raeside²

1973

Reproduction

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The effects of oestrogens on the activity of accessory sex glands were studied in castrated boars receiving testosterone continuously. Diethylstilboestrol (DES), 17\g=b\-oestradiol(E2) and oestrone (E1) were administered successively for 6-week periods which alternated with treatments of testosterone alone. Semen was collected twice each week and measurements were made of the total, the strained and the gel volumes. Citric acid and fructose contents of the seminal plasma were also determined. Highly significant (P<0\m=.\01) differences between boars were observed for all criteria in a series of collections made before castration.Castration resulted in reduction in the total quantities of secretory products of the accessory sex glands. Subsequent treatment with testosterone alone for a period of 12 weeks had only a slight effect on their secretions. Supplementary treatment with DES, E2 or E1 significantly (P<0\m=.\01) increased the secretory activity of these glands from the levels in the respective preceding periods with testosterone alone. After withdrawal of oestrogens, the elevated levels of citric acid secretion remained high or increased further, while the amounts of seminal plasma and fructose continued at the higher levels or declined.Oestrogens also had a synergistic effect with testosterone on improving the libido of castrated boars. The reaction time was decreased by 45% (P<0\m=.\01)during supplementary treatment with oestrone for 12 weeks.The results of these experiments suggest that oestrogens act synergistically with testosterone on the accessory sex glands and on the sexual behaviour of the boar.

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Section: Discussionmentioning

confidence: 77%

Synergistic Effects of Testosterone and Oestrogens on Accessory Sex Glands and Sexual Behaviour of the Boar

Joshi¹,

Raeside²

1973

Reproduction

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“…A number of studies have supported the beneWcial eVects of DES (diethylstilbestrol, a very potent synthetic estrogen) and other estrogenic compounds on weight gain in cattle and sheep (Dinusson et al 1948(Dinusson et al , 1950Andrews et al 1949). In contrast, estrogens have not been considered to be particularly eVective growth enhancers in pigs (Roche and Quirke 1986), and contradictory results have been found regarding the eVects on growth rate, carcass quality, and composition (Braude 1947;Dinusson et al 1951;Elliot and Fowler 1974). In addition to indirect eVects of estrogen, mediated through an increase in somatotropin secretion, it is possible that estrogens may have a direct eVect on muscle (Heitzman 1979a, b).…”

Section: Introductionmentioning

confidence: 92%

Evidence for estrogen receptor α and β expression in skeletal muscle of pigs

Kalbe

Mau

Wollenhaupt

et al. 2006

Histochem Cell Biol

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Recent research suggests that estrogen receptors (ERs) are of significance in skeletal muscle function. The aim of the present study was to investigate, whether ERalpha and ERbeta are expressed in different porcine skeletal muscles and in satellite cells derived from semimembranosus muscle (SM) at the protein and mRNA level. Immunohistochemistry demonstrated positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells. Additionally, a weak expression of both ER subtypes was seen in skeletal muscle tissue and SM satellite cells with Western blot analysis. A clear expression of the ERalpha mRNA and a weak expression of the ERbeta mRNA was seen in skeletal muscle tissue and SM satellite cell cultures, as determined by reverse transcription (RT)-PCR. The present study shows for the first time that both ERalpha and ERbeta are expressed in porcine skeletal muscle, which, consequently, could be considered as a target tissue for estrogens or estrogen-like compounds. However, more detailed studies on the functional impact of both receptor subtypes in skeletal muscle are necessary. The porcine SM satellite cell culture provides a suitable in vitro model to investigate estrogenic effects on pig skeletal muscle.

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“…However, at least in some species in which oestrogen secretion is normally low (man, dog), oestrogen treatment will give clear signs of feminization. In this connection it is especially noteworthy also that the castrate boar has been shown to respond to exogenous oestrogens with mammary development, and with regained ability to erection of the penis and arousal of sexual desire (Dinusson, Klosterman & Buchanan, 1951). In these experiments the substance used was stilboestrol, which was implanted subcutaneously.…”

Section: Clinical Significance Of Urinary Oestrogen Determinations Inmentioning

confidence: 98%

Urinary Oestrogens in the Male

Velle¹

1966

Reproduction

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Oestrogenic activity in urine from males was detected as early as 1927. A few years later mass excretion of oestrogens was detected in the stallion and other equines, and in the boar.The following naturally occurring oestrogens have been chemically identified in urine from males: oestrone (stallion, bull, boar, man, rat), oestradiol-17\g=b\(stallion, boar, man, rat), oestradiol-17\g=a\(stallion, rat), oestriol (man).The levels of oestrogens in male urine is subject to very marked species differences, the stallion showing extremely high levels, followed by other equines and by the domestic boar. During recent years a large number of wild animals has been screened for oestrogens in urine. Generally the values are very low, a few \g=m\g/100 ml of urine, while for stallion's urine the values recorded are in the mg range.The testicular origin of the major part of urinary oestrogens was early anticipated and has been confirmed by recent biochemical investigations. A minor part is probably of adrenal origin.The biological significance of oestrogenic hormones in the male is obscure. Mass secretion of the hormones in males of some species still represents an enigma.The first unequivocal demonstration of the presence of a specific oestrogenic hormone in the mammalian ovary was made about 40 years ago (Allen & Doisy, 1923, 1924. The designation of the substance as the female sex hormone (Frank, 1929) seemed at first to be appropriate, especially since its presence had by then been demonstrated in female blood (Loewe, 1925) and in human pregnancy urine (Aschheim & Zondek, 1927). These original observations pertaining to the female were, however, soon followed by reports of some oestrogen activity also in testes, and in urine from men, indicating that oestrogenic hormones were not entirely sex specific. Then followed the first reports on very high levels of oestrogenic activity in stallion's urine which paradoxically appeared to be one of the richest sources ever found for 'female sex hormones'.Those who have seen a fiery stallion will hardly refute its masculinity. Nevertheless, its daily oestrogen output exceeds that of the non-pregnant female animal by a factor of 100 to 200.Ever since this discovery, the question of how a male may retain its mascu¬ linity in spite of such an enormous oestrogen secretion has remained one of the 65

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Stilbestrol, Effect of Subcutaneous Implantation on Growing-Fattening Swine

Cited by 18 publications

References 0 publications

Synergistic Effects of Testosterone and Oestrogens on Accessory Sex Glands and Sexual Behaviour of the Boar

Synergistic Effects of Testosterone and Oestrogens on Accessory Sex Glands and Sexual Behaviour of the Boar

Evidence for estrogen receptor α and β expression in skeletal muscle of pigs

Urinary Oestrogens in the Male

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