Stifle joint osteoarthritis in small‐breed and medium‐breed dogs is more severe after cranial cruciate ligament injury than medial patellar luxation

Villatoro, Ashley S.; Langenbach, Anke; Yoon, Jihyun; Garcia, Tanya C.; Marcellin‐Little, Denis J.

doi:10.1111/vru.13207

Cited by 3 publications

(4 citation statements)

References 22 publications

(41 reference statements)

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“…In dogs with CrCLD where menisci remain intact, even conservative treatment can have a functional outcome albeit including OA. In summary, it should be clear that canine CrCLD will lead to loss of joint function and progressive OA in all cases ( 93 , 94 ).…”

Section: Animals As Translational Research Modelsmentioning

confidence: 99%

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Osteoarthritis, adipokines and the translational research potential in small animal patients

Theyse,

Mazur

2024

Front. Vet. Sci.

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Osteoartritis (OA) is a debilitating disease affecting both humans and animals. In the early stages, OA is characterized by damage to the extracellular matrix (ECM) and apoptosis and depletion of chondrocytes. OA progression is characterized by hyaline cartilage loss, chondrophyte and osteophyte formation, thickening of the joint capsule and function loss in the later stages. As the regenerative potential of cartilage is very limited and osteoarthritic changes are irreversible, prevention of OA, modulation of existing osteoarthritic joint inflammation, reducing joint pain and supporting joint function are the only options. Progression of OA and pain may necessitate surgical intervention with joint replacement or arthrodesis as end-stage procedures. In human medicine, the role of adipokines in the development and progression of OA has received increasing interest. At present, the known adipokines include leptin, adiponectin, visfatin, resistin, progranulin, chemerin, lipocalin-2, vaspin, omentin-1 and nesfatin. Adipokines have been demonstrated to play a pivotal role in joint homeostasis by modulating anabolic and catabolic balance, autophagy, apoptosis and inflammatory responses. In small animals, in terms of dogs and cats, naturally occurring OA has been clearly demonstrated as a clinical problem. Similar to humans, the etiology of OA is multifactorial and has not been fully elucidated. Humans, dogs and cats share many joint related degenerative diseases leading to OA. In this review, joint homeostasis, OA, adipokines and the most common joint diseases in small animals leading to naturally occurring OA and their relation with adipokines are discussed. The purpose of this review is highlighting the translational potential of OA and adipokines research in small animal patients.

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Section: Animals As Translational Research Modelsmentioning

confidence: 99%

“…These techniques do have the potential decreasing internal rotation instability. Nevertheless, these artificial (93,94). Traumatic cruciate and collateral ligament lesions most commonly in combination with meniscal tears occasionally occur in dogs, but are more common in cats.…”

Section: Cranial Cruciate Ligament Diseasementioning

confidence: 99%

Osteoarthritis, adipokines and the translational research potential in small animal patients

Theyse,

Mazur

2024

Front. Vet. Sci.

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“…Previous studies have shown that breed predisposition plays a role in the development of OA. 2‐6 For example, boxers, Yorkshire terriers and West Highland white terriers typically present with higher OA scores than other breeds of similar sizes 3 , 4 …”

Section: Figurementioning

confidence: 99%

Evaluating the relationship between osteoarthritis and cruciate ligament disease in dogs

Langenbach¹

2023

Veterinary Record

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“…These conditions arise from bone inflammation and structural abnormalities [6]. If left untreated, prolonged MPL and CCLR can result in increased contact between the femur and tibia resulting in osteoarthritis [7].…”

Section: Introductionmentioning

confidence: 99%

Bacterial DNA and osteoarthritis in dogs with patellar luxation and cranial cruciate ligament rupture

Tuek-Um,

Yangtara,

Surachetpong

et al. 2023

Vet World

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Background and Aim: The association between bacterial DNA in stifle joints, including those with cranial cruciate ligament rupture (CCLR) and medial patellar luxation (MPL), and osteoarthritis in dogs remains elusive. This study investigated the potential association between the detection of bacterial DNA and osteoarthritis in dogs using a broad-range polymerase chain reaction technique targeting the 16S ribosomal RNA gene. Materials and Methods: Synovial fluid (35 samples) and knee tissue samples (32 samples) were obtained from 35 dogs diagnosed with CCLR (n = 20; 11 males and nine females) or MPL (n = 15; five males and 10 females) who underwent a surgical operation between October 2014 and April 2015. Results: Dogs with CCLR had a higher average osteoarthritis score than those with MPL (2.0 ± 0.9 vs. 0.5 ± 0.9; p = 0.005). Bacterial DNA was detected in the stifle joints of 60.71% of dogs with MPL. Pelomonas spp. (25.00%), Halomonas spp. (17.86%), and 5 other species (17.86%) were the most frequently identified bacteria. Bacterial DNA was detected in 41.03% of dogs with CCLR. Pelomonas spp. (15.38%), Sphingomonas spp. (10.26%), Halomonas spp. (5.13%), and 4 other species (10.26%) were the most frequently identified bacteria. No significant difference was observed in the prevalence of bacterial DNA obtained from tissue samples (46.88%) or joint fluid samples (51.43%). The presence of bacterial DNA was not associated with the type of knee injury (MPL or CCLR; p = 1.000). There was a higher prevalence of bacterial DNA in samples from dogs with moderate-to-severe osteoarthritis (94.44%) than in those with minimal osteoarthritis (41.18%), and a significant association between the presence of bacterial DNA and moderate-to-severe osteoarthritis was identified (p < 0.01). Conclusion: Dogs with moderate-to-severe osteoarthritis were more likely to have bacterial DNA in their stifle joints than those with no or minimal osteoarthritis. These findings provide valuable insight into the potential role of bacterial DNA in joint tissue or joint fluid and the development of osteoarthritis in dogs. Keywords: bacterial DNA, cranial cruciate ligament, osteoarthritis, stifle.

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Stifle joint osteoarthritis in small‐breed and medium‐breed dogs is more severe after cranial cruciate ligament injury than medial patellar luxation

Cited by 3 publications

References 22 publications

Osteoarthritis, adipokines and the translational research potential in small animal patients

Osteoarthritis, adipokines and the translational research potential in small animal patients

Evaluating the relationship between osteoarthritis and cruciate ligament disease in dogs

Bacterial DNA and osteoarthritis in dogs with patellar luxation and cranial cruciate ligament rupture

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