Stiffness of the aortic wall in hypercholesterolemic children

Impaired coronary flow velocity reserve and aortic distensibility in patients with untreated hypercholesterolemia—an echocardiographic study

“…Iannuzzi et al demonstrated an influence of hypercholesterolemia on age-related modification in the elastic properties of the aorta. A remodelling of the aortic wall in HC children could explain the different age-dependent increase in aortic elastic modulus and stiffness [33]. Stiffness parameter b of the descending aorta assessed by TEE, which was measured in portions where the intima was morphologically normal or mildly thickened, was significantly higher in familial and non-familial hypercholesterolemic patients, thus clearifying that the stiffness of the aorta in hyperlipidemic patients has already been increased before exacerbation of aortic atherosis even begins [6].…”

“…Several previous studies demonstrated impaired aortic distensibility evaluated by different techniques in HC patients [6,[32][33][34][35][36][37][38][39]. Severe dyslipidemia does not overtly influence aortic dimensions but leads to impairment of aortic elastic properties before the occurance of clinical manifestations of atherosclerotic disease [32].…”

Increase in Pulse Pressure Relates to Diabetes Mellitus and Low HDL Cholesterol, but Not to Hyperlipidemia in Hypertensive Patients Aged 50 Years or Older.

“…These studies examined patients with familial hypercholesterolemia characterized by extremely high serum cholesterol levels. Earlier studies have also reported an absence of significant association between arterial stiffness and hyperlipidemia (38,39). One of these studies (38) examined hypercholesterolemic children at the age of 3 to 14 years.…”

Adjunctive Testing in the Evaluation of Adults After Kawasaki Disease

“…24-29 Decreased arterial elasticity can be detected in childhood in those with cardiovascular risk factors. 30, 31 Arterial stiffness can be assessed noninvasively using pulse wave velocity (PWV) or the β stiffness index (SI) of the carotid artery. 32 PWV measurement involves measuring the timing and magnitude of the reflected pressure wave that …”