Impaired coronary flow velocity reserve and aortic distensibility in patients with untreated hypercholesterolemia—an echocardiographic study

Nemes, Attila; Forster, Tamás; Csanády, Miklós

doi:10.1007/s10554-006-9103-x

Cited by 22 publications

(16 citation statements)

References 38 publications

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“…Nemes et al (46) described reduced CFR and increased indices of aortic stiffness [E(p) and E(s)] in patients with LAD coronary artery disease as compared with patients with normal epicardial coronary arteries. In addition to these findings in patients with coronary artery disease, Nemes et al demonstrated significant correlations between CFR and aortic stiffness in patients without coronary artery disease, but with hypertension, aortic valve stenosis, type-2 diabetes and hypercholesterolemia (16)(17)(18)(19). However, presence of an association between aortic stiffness and impaired CFR in MetS has never been evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…This together with the decreased diastolic transmyocardial pressure gradient interacts with coronary flow and flow reserve (11). Significant correlations between coronary flow reserve and aortic stiffness parameters have been demonstrated in different populations such as hypertension, aortic valve stenosis, and hypercholesterolemia (16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

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Impaired coronary flow reserve evaluated by echocardiography is associated with increased aortic stiffness in patients with metabolic syndrome: an observational study

Tok¹,

Özcan²,

Kadife³

et al. 2013

AnadoluKardiyolDerg

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Impaired coronary flow reserve evaluated by echocardiography is associated with increased aortic stiffness in patients with metabolic syndrome: an observational studyMetabolik sendromlu hastalarda ekokardiyografik olarak gösterilen bozulmuş koroner akım rezervi artmış aort sertliği ile ilişkilidir: Gözlemsel bir çalışma ABSTRACTObjective: Metabolic syndrome (MetS) is a strong predictor of cardiovascular events and coronary flow reserve (CFR), an indicator of microvascular function, has been found to be impaired in MetS. Aortic stiffness (AS) is a simple and effective method for assessing arterial elasticity. The aim of this study was to evaluate whether there is an independent association of impaired coronary flow and aortic elasticity in patients with MetS. Methods: Forty-six patients (mean age 47.3±6.6 years) with the diagnosis of MetS according to the ATP III update criteria and 44 age and gender matched controls (mean age 46.0±6.1 years) were included into the cross-sectional observational study. Peak diastolic coronary flow velocities were measured in left anterior descending artery by pulsed wave Doppler at baseline and after adenosine infusion, and CFR was calculated as the ratio of hyperemic to baseline velocities. Aortic strain, distensibility and stiffness were calculated by M-mode echocardiography. Statistical analysis was performed by using Student t-test, Chi-square test, Pearson correlation and linear regression analyses. Results: CFR was significantly lower in patients with MetS than in controls (2.3±0.2 vs 2.7±0.2, p<0.001). In the MetS group, aortic distensibility (10.4±3.5 cm 2 .dyn -1 .10 -6 vs. 12.7±3.4 cm 2 .dyn -1 .10 -6 , p=0.002) was decreased and AS was significantly increased (6.5±2.0 vs. 3.2±0.8, p<0.001). In multivariate linear regression analysis, AS (β=-0.217, p=0.047), systolic blood pressure (β=-0.215, p=0.050) and waist circumference (β=-0.272, p=0.012) had an independent relationship with impaired CFR. Conclusion: This study demonstrated that coronary flow reserve is impaired in patients with MetS and there is an independent relationship between impaired CFR and increased aortic stiffness, systolic blood pressure or waist circumference. (Anadolu Kardiyol Derg 2013; 13: 227-34)

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impaired coronary flow reserve evaluated by echocardiography is associated with increased aortic stiffness in patients with metabolic syndrome: an observational study

Tok¹,

Özcan²,

Kadife³

et al. 2013

AnadoluKardiyolDerg

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“…1 Systolic and diastolic ascending aortic diameters (SD and DD, respectively) can be recorded by M-mode echocardiography at a level of 3 cm above the aortic valve from parasternal long-axis view. The SD and DD were measured at the maximum anterior motion of the aorta and at the peak of QRS complex on the simultaneously recorded ECG, respectively variety of diseases [10][11][12][13]. There are numerous techniques for assessing the early stages of vascular disease and stiffness including pulse wave analysis or direct measurements.…”

Section: Discussionmentioning

confidence: 99%

Obesity is associated with aortic enlargement and increased stiffness: an echocardiographic study

Nemes

Gavallér

Csajbók

et al. 2007

Int J Cardiovasc Imaging

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“…type-2 diabetes, 37 and hypercholesterolemia, 38 with significant correlations between the parameters. These studies confirm the relationship between the parameters of aortic stiffness and CFR.…”

Section: Reviews Continuedmentioning

confidence: 92%

Echocardiographic Evaluation and Clinical Implications of Aortic Stiffness and Coronary Flow Reserve and their Relation

Nemes

Geleijnse

Forster

et al. 2007

Clinical Cardiology

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The normal human aorta is not a stiff tube, but is characterized by elastic properties with a buffering Windkessel function. Aortic stiffening may cause an increase in aortic pulse pressure, left ventricular (LV) load, and ultimately left ventricular hypertrophy. This, together with the decreased diastolic transmyocardial pressure gradient, interacts with coronary flow and flow reserve. In recent studies, significant correlations between coronary flow reserve and aortic stiffness have been demonstrated in different patient populations. The aim of this review is to describe the current echocardiographic modalities to measure aortic stiffness and coronary flow reserve, and to overview knowledge about the relationship between aortic stiffness and coronary flow reserve.

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Impaired coronary flow velocity reserve and aortic distensibility in patients with untreated hypercholesterolemia—an echocardiographic study

Abstract: In conclusion it may be stated that CFR and aortic distensibility indices can be evaluated simultaneously by stress TEE in HC patients. CFR and aortic distensibility were impaired in HC patients as compared to NC subjects.

Cited by 22 publications

References 38 publications

Impaired coronary flow reserve evaluated by echocardiography is associated with increased aortic stiffness in patients with metabolic syndrome: an observational study

Impaired coronary flow reserve evaluated by echocardiography is associated with increased aortic stiffness in patients with metabolic syndrome: an observational study

Obesity is associated with aortic enlargement and increased stiffness: an echocardiographic study

Echocardiographic Evaluation and Clinical Implications of Aortic Stiffness and Coronary Flow Reserve and their Relation

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